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151.
Scott McN. Sieburth Thomas Nittoli Alfred M. Mutahi Luxuan Guo 《Angewandte Chemie (International ed. in English)》1998,37(6):812-814
Transition state analogues of the peptide hydrolysis intermediate can take the form of complex silanediols such as 1 , which inhibits angiotensin-converting enzyme (ACE) at nanomolar concentrations. In contrast, earlier investigation of enzyme inhibition with simple silanediols and silanetriols showed them to be inactive. 相似文献
152.
Dipl.‐Pharm. Christian Wölk Dr. Simon Drescher Dr. Annette Meister Prof. Dr. Alfred Blume Prof. Dr. Andreas Langner Prof. Dr. Bodo Dobner 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(38):12824-12838
A series of novel malonic acid diamides (second generation) with two long hydrophobic alkyl chains and an alkaline polar head group was synthesised and characterised as a new class of amino‐functionalised lipids. These peptide‐mimic lipids are suitable for polynucleotide transfer. The lipids bear a novel backbone consisting of a lysine unit and a malonic acid unit. Six different head‐group structures, which vary in size and number of amino groups that can be protonated, were attached to the backbone structure. Furthermore, different alkyl chains were used to build the lipophilic part (namely tetradecyl, hexadecyl, and oleyl). Phase transitions of the new compounds in aqueous dispersions at pH 10 were analysed and discussed in terms of head group and alkyl chain variations. The shape and size of the formed aggregates of selected lipid dispersions were investigated by dynamic light scattering and transmission electron microscopy. 相似文献
153.
Weisshoff H Preiss A Nehls I Win T Mügge C 《Analytical and bioanalytical chemistry》2002,373(8):810-819
A hyphenated HPLC-(1)H NMR method for the identification and quantification of PAHs in soil samples has been developed and applied to a PAH reference sample provided by the Federal Institute for Materials Research and Testing (BAM, Berlin, Germany). The results were compared with those obtained by HPLC-DAD, HPLC-F, and GC-MS analyses of the same sample. 相似文献
154.
155.
Briggs BN McMillin DR Todorova TK Gagliardi L Poineau F Czerwinski KR Sattelberger AP 《Dalton transactions (Cambridge, England : 2003)》2010,39(47):11322-11324
The emission spectra of the solids [n-Bu(4)N](2)Tc(2)X(8) (X = Cl, Br) have been investigated at room temperature and 77 K. In each case, the emission originates in the (1)δ-δ* excited state, as with the rhenium homologues, but has a shorter lifetime. 相似文献
156.
Xiangli Liu Ping Fan Ming Chen Hossam Hefesha GerhardK.E. Scriba Detlef Gabel Alfred Fahr 《Helvetica chimica acta》2010,93(2):203-211
The objective of this study was to investigate drug–membrane interaction by immobilized liposome chromatography (ILC; expressed as lipophilicity index log Ks) and the comparison with lipophilicity indices obtained by liposome/H2O, octan‐1‐ol/H2O, and immobilized artificial membrane (IAM) systems. A set of structurally diverse monofunctional compounds and drugs (nonsteroidal anti‐inflammatory drugs and β‐blockers) were selected in this study. This set of solutes consists of basic or acidic functionalities which are positively or negatively charged at physiological pH 7.4. No correlation was found between log Ks from ILC and lipophilicity indices from any of the other membrane model systems for the whole set of compounds. For structurally related compounds, significant correlations could be established between log Ks from ILC and lipophilicity indices from IAM chromatography and octan‐1‐ol/H2O. However, ILC and liposome/H2O systems only yield parallel partitioning information for structurally related large molecules. For hydrophilic compounds, the balance between electrostatic and hydrophobic interactions dominating drug partitioning is different in these two systems. 相似文献
157.
Jessica A. Zimberlin Alfred J. Crosby 《Journal of polymer science. Part A, Polymer chemistry》2010,48(13):1423-1427
Using the cavitation rheology (CR) technique developed in our labs, we show that fluids with negligible interfacial tensions with a surrounding material can be used to induce an elastic, cavitation instability in that material. We do this by changing the cavitation media from air, which was demonstrated to induce cavitation at the tip of a syringe needle in previous studies, to water, which has a negligible surface tension with the surrounding poly(vinyl alcohol) hydrogel material. In this case, the critical pressure in which this instability occurs can be directly related to the elastic modulus of the surrounding network and is shown to be nearly independent of length scale. This independence of size scale has important implications in the use of CR for the characterization of mechanical properties from molecular to macroscopic length scales. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 1423–1427, 2010 相似文献
158.
Sakakibara K Nakatsubo F French AD Rosenau T 《Chemical communications (Cambridge, England)》2012,48(62):7672-7674
Right-handedness derived from bisporphyrins attached to a cellotriose backbone at O-6 and O'-6 positions is revealed for the first time. This cellotriose is proposed as a model of alternatingly functionalized cellulosics, which have promising properties for applications in optoelectronics and molecular receptors owing to the chirality and rigid backbone effects. 相似文献
159.
Simal F Delfosse S Demonceau A Noels AF Denk K Kohl FJ Weskamp T Herrmann WA 《Chemistry (Weinheim an der Bergstrasse, Germany)》2002,8(13):3047-3052
Air-stable and readily available ruthenium benzylidene complexes of the general type [RuCl2(=CHPh)(L)(L')] (L, L' = PCy3 and/or N-heterocyclic carbene) constitute a new class of catalyst precursors for atom-transfer radical polymerization (ATRP) of methyl methacrylate and styrene, and provide an unprecedented example for the involvement of ruthenium alkylidenes in radical reactions. They promote the polymerization of various monomers with good to excellent yields, and in a controlled way with methyl methacrylate and styrene. Variations of their basic structural motif provide insights into the essential parameters responsible for catalytic activity. The ligands L (PCy3 and/or N-heterocyclic carbene) turned out to play a particularly important role in determining the rate of the polymerizations. A similarly pronounced influence is exerted by the substituents on the N-heterocyclic carbene. Our results indicate that the catalysts decompose quickly under ATRP conditions, and polymerizations are mediated by both [RuCl2(=CHPh)(L)(L')] complexes and ruthenium species bereft of the benzylidene moiety, through a pathway in which both tricyclohexylphosphane and/or N-heterocyclic carbene ligands remain bound to the metal center. Polymerization of n-butyl acrylate and vinyl acetate is not controlled and most probably takes place through a redox-initiated free-radical process. 相似文献
160.
Köhler K Förster G Hauser A Dobner B Heiser UF Ziethe F Richter W Steiniger F Drechsler M Stettin H Blume A 《Journal of the American Chemical Society》2004,126(51):16804-16813
The temperature-dependent self-assembly of the single-chain bolaamphiphile dotriacontan-1,1'-diyl-bis[2-(trimethylammonio)ethyl phosphate] (PC-C32-PC) was investigated by transmission electron microscopy (TEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), X-ray scattering, rheological measurements, and dynamic light scattering (DLS). At room temperature this compound, in which two phosphocholine headgroups are connected by a C(32) alkyl chain, proved to be capable of gelling water very efficiently by forming a dense network of nanofibers (Kohler et al. Angew. Chem., Int. Ed. 2004, 43, 245). A specific feature of this self-assembly process is that it is not driven by hydrogen bonds but solely by hydrophobic interactions of the long alkyl chains. The nanofibers have a thickness of roughly the molecular length and show a helical superstructure. A model for the molecular structure of the fibrils which considers the extreme constitution of the bolaamphiphile is proposed. Upon heating the suspensions three different phase transitions can be detected. Above 49 degrees C, the temperature of the main transition where the alkyl chains become "fluid", a clear low-viscosity solution is obtained due to a breakdown of the fibrils into smaller aggregates. Through mechanical stress the gel structure can be destroyed as well, indicating a low stability of these fibers. The gel formation is reversible, but as a drastic rearrangement of the molecules takes place, metastable states occur. 相似文献