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21.
O. E. Nasakin A. N. Lyshchikov P. M. Lukin A. Kh. Bulai 《Chemistry of Heterocyclic Compounds》1994,30(3):312-316
The reaction of 1,1,2,2-tetracyanoethane with 1-R,3-R,5-R-2,4-diazapenta-1, 4-dienes leads to 2,5-disubstituted 3,3,4,4-tetracyanopyrrolidines. The conditions for the acylation of the last were selected.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 353–358, March, 1994. 相似文献
22.
O. E. Nasakin A. N. Lyshchikov P. M. Lukin A. Kh. Bulai V. A. Tafeenko P. A. Sharbatyan 《Chemistry of Heterocyclic Compounds》1991,27(11):1212-1217
2,5-Substituted 3,3,4,4-tetracyanopyrrolidines react with primary alcohols in the presence of an excess of a base or with the base itself. 2-(N-Arylideneamino)-5-alkoxy-3,4-dicyanopyrroles are formed as a result of the reactions with alcohols, and 2,5-diamino-1-R-3,4-dicyanopyrroles are formed as the result of the reaction with primary aliphatic amines.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1502–1507, November, 1991. 相似文献
23.
A. B. Zolotoi S. V. Konovalikhin N. M. Sergeev A. V. Buevich P. N. Lukin A. N. Lyshchikov M. Yu. Skvortsova S. P. Zil'berg O. E. Nasakin 《Journal of Structural Chemistry》1990,31(3):464-471
For communication 13, see [1]. 相似文献
24.
A. B. Zolotoi S. V. Konovalikhin P. M. Lukin O. A. D'yachenko S. P. Zil'berg O. E. Nasakin 《Chemistry of Heterocyclic Compounds》1988,24(10):1166-1171
The Michael condensation of 1,1,2,2-tetracyanoethane with 3-methyl-4-benzylideneisoxazolin-5-one having the Z configuration leads to a heterocyclic spiran with retention of the cis orientation of the phenyl and keto groups. The deviations of the series of bond angles of the spiran from the standard values, the abnormal lengths of the C-C bonds adjacent to the gem-dicyano group, and the appearance of nonbonding >C=O(...)CN interactions and conjugation effects in the enaminonitrile fragment are discussed.For Communication 10, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1404–1410, October, 1988. 相似文献
25.
The structural and thermodynamic properties of the donor-acceptor (DA) complexes of Group 13 metal halides (MX3) with ethylenediamine and their decomposition products have been studied theoretically at the B3LYP/LANL2DZ(d,p) level of theory. Gas-phase dissociation into various components and HX elimination reactions are considered. Both processes are endothermic but favored by entropy. Complexes of 2:1 composition are predicted to be stable in the gas phase up to 640-1000 K. It is found that complexation with the second acceptor molecule lowers the HX elimination enthalpy; in turn, HX elimination increases DA bonding with a second MX3 molecule. Exceptionally high values of the dissociation enthalpies (310-390 kJ mol(-1)) and HX elimination reactions (360-420 kJ mol(-1)) of the amido compounds MX2NHC2H4NH2 and MX2NHC2H4NHMX2 make them important intermediates in the decomposition processes. Dissociation reactions of the complexes are more favorable than HX elimination reactions; however, the subsequent oligomerization and cyclization processes of coordinationally unsaturated amido and imido compounds may facilitate HX elimination. Since HI elimination reactions are predicted to be the least endothermic, and aluminum-containing compounds have the strongest M-N dissociation enthalpies, it is expected that compounds based on aluminum iodide are promising objects for experimental studies. 相似文献
26.
The reaction of α-halosubstituted β-ethoxyvinyl trifluoromethyl ketones with 2-aminopyridine gives 3-trifluoroacetyl imidazo[1,2-a]pyridine and 3-halo-1,1,1-trifluoro-4-(2-pyridinylamino)-3-buten-2-ones. The product ratio depends on the nature of the α-halogen atom and the solvent. 相似文献
27.
Biosensors based on enzyme field-effect transistors for determination of some substrates and inhibitors 总被引:3,自引:0,他引:3
Dzyadevych SV Soldatkin AP Korpan YI Arkhypova VN El'skaya AV Chovelon JM Martelet C Jaffrezic-Renault N 《Analytical and bioanalytical chemistry》2003,377(3):496-506
This paper is a review of the authors' publications concerning the development of biosensors based on enzyme field-effect transistors (ENFETs) for direct substrates or inhibitors analysis. Such biosensors were designed by using immobilised enzymes and ion-selective field-effect transistors (ISFETs). Highly specific, sensitive, simple, fast and cheap determination of different substances renders them as promising tools in medicine, biotechnology, environmental control, agriculture and the food industry.The biosensors based on ENFETs and direct enzyme analysis for determination of concentrations of different substrates (glucose, urea, penicillin, formaldehyde, creatinine, etc.) have been developed and their laboratory prototypes were fabricated. Improvement of the analytical characteristics of such biosensors may be achieved by using a differential mode of measurement, working solutions with different buffer concentrations and specific agents, negatively or positively charged additional membranes, or genetically modified enzymes. These approaches allow one to decrease the effect of the buffer capacity influence on the sensor response in an aim to increase the sensitivity of the biosensors and to extend their dynamic ranges.Biosensors for the determination of concentrations of different toxic substances (organophosphorous pesticides, heavy metal ions, hypochlorite, glycoalkaloids, etc.) were designed on the basis of reversible and/or irreversible enzyme inhibition effect(s). The conception of an enzymatic multibiosensor for the determination of different toxic substances based on the enzyme inhibition effect is also described.We will discuss the respective advantages and disadvantages of biosensors based on the ENFETs developed and also demonstrate their practical application. 相似文献
28.
[reaction: see text] Radical/polar crossover reactions of derivatives of 1-(2-cyclobutenyl)-2-(2-iodoaryl)ethanones with acetone promoted by samarium diiodide and HMPA provide 1-(1-hydroxy-1-methylethyl)-2,2a,4,8b-tetrahydro-1H-cyclobuta[a]naphthalen-3-one derivatives in about 50% isolated yield. This reaction shows promise for construction of the BCD ring fragment of the penitrems. 相似文献
29.
Ya. S. Kayukov P. M. Lukin O. E. Nasakin V. N. Khrustalev V. N. Nesterov M. Yu. Antipin V. V. Sheverdov 《Chemistry of Heterocyclic Compounds》1997,33(4):423-425
It has been established by x-ray structural analysis that on reacting 4-oxoalkane-1,1,2,2-tetracarbonitriles with aldehydes
6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles are formed and not 3-imino-2,6-dioxabicyclo[2,2,2] octane-4,8,8-tricarbonitriles
as has been proposed.
Chuvash State University, Cheboksary 428015. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 497–499,
April, 1997. 相似文献
30.
Acylation of 4-α-furyl-4-N-benzylaminobut-1-enes with maleic anhydride gave 4-oxo-3-aza-10-oxatricyclo[5.2.1.01,5]dec-8-ene-6-carboxylic acid via amide formation followed by intramolecular Diels-Alder reaction of furan (IMDAF). The cycloaddition proceeded under mild reaction conditions (25 °C) and provided only the exo-adduct in quantitative yield. Treatment of this compound with PPA gave isoindolo[2,1-b][2]benzazepine derivatives via ring opening, aromatization and intramolecular electrophilic alkylation. In order to extend the scope of the reaction sequence, 7-oxo-5,11b,12,13-tetrahydro-7H-isoindolo[2,1-b][2]benzazepine-8-carboxylic acids were further transformed into useful synthetic intermediates. 相似文献