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191.
Bendini A Cerretani L Carrasco-Pancorbo A Gómez-Caravaca AM Segura-Carretero A Fernández-Gutiérrez A Lercker G 《Molecules (Basel, Switzerland)》2007,12(8):1679-1719
Among vegetable oils, virgin olive oil (VOO) has nutritional and sensory characteristics that to make it unique and a basic component of the Mediterranean diet. The importance of VOO is mainly attributed both to its high content of oleic acid a balanced contribution quantity of polyunsaturated fatty acids and its richness in phenolic compounds, which act as natural antioxidants and may contribute to the prevention of several human diseases. The polar phenolic compounds of VOO belong to different classes: phenolic acids, phenyl ethyl alcohols, hydroxy-isochromans, flavonoids, lignans and secoiridoids. This latter family of compounds is characteristic of Oleaceae plants and secoiridoids are the main compounds of the phenolic fraction. Many agronomical and technological factors can affect the presence of phenols in VOO. Its shelf life is higher than other vegetable oils, mainly due to the presence of phenolic molecules having a catechol group, such as hydroxytyrosol and its secoiridoid derivatives. Several assays have been used to establish the antioxidant activity of these isolated phenolic compounds. Typical sensory gustative properties of VOO, such as bitterness and pungency, have been attributed to secoiridoid molecules. Considering the importance of the phenolic fraction of VOO, high performance analytical methods have been developed to characterize its complex phenolic pattern. The aim of this review is to realize a survey on phenolic compounds of virgin olive oils bearing in mind their chemical-analytical, healthy and sensory aspects. In particular, starting from the basic studies, the results of researches developed in the last ten years will be focused. 相似文献
192.
Altland K Benson MD Costello CE Ferlini A Hazenberg BP Hund E Kristen AV Linke RP Merlini G Salvi F Saraiva MJ Singer R Skinner M Winter P 《Electrophoresis》2007,28(12):2053-2064
Mutations of the human transthyretin (TTR) gene have attracted medical interest as a cause of amyloidosis. Recently, we have described in detail an electrophoretic procedure with PAGE followed by IEF in urea gradients for the study of the microheterogeneity of TTR monomers (Altland, K., Winter, P., Sauerborn, M. K., Electrophoresis 1999, 20, 1349-1364). In this paper, we present a study on 49 different mutations of TTR including 33 that result in electrically neutral amino acid substitutions. The aims of the investigation were to test the sensitivity of the procedure to detect TTR variants in patients with TTR amyloidosis and their relatives and to identify some common characteristics that could explain the amyloidogenicity of these variants. We found that all tested amyloidogenic mutations could be detected by our method with the exception of those for which the corresponding variant was absent in plasma samples. Most of the electrically neutral amyloidogenic TTR variants had in common a reduced conformational stability of monomers by the activity of protons and urea. For three variants, e.g. TTR-F64L, TTR-I107V and TTR-V122I, the monomers had a conformational stability close to that of normal monomers but we found experimental and structural arguments for a weakening of the monomer-monomer contact. All types of amyloidogenic mutations affected the stability of TTR tetramers. 相似文献
193.
We establish sufficient conditions for a cohomology class of a discrete subgroup Γ of a connected semisimple Lie group with finite center to be representable by a bounded differential form on the quotient by Γ of the associated symmetric space; furthermore if \(\rho : \Gamma\to\mathrm{PU}(1,q)\) is any representation of any discrete subgroup Γ of SU (1, p), we give an explicit closed bounded differential form on the quotient by Γ of complex hyperbolic space which is a representative for the pullback via ρ of the Kähler class of PU(1,q). If G,G′ are Lie groups of Hermitian type, we generalize to representations \(\rho : \Gamma\to G'\) of lattices Γ < G the invariant defined in [Burger, M., Iozzi, A.: Bounded cohomology and representation variates in PU (1,n). Preprint announcement, April 2000] for which we establish a Milnor–Wood type inequality. As an application we study maximal representations into PU(1, q) of lattices in SU(1,1). 相似文献
194.
Favaro G di Nunzio MR Gentili PL Romani A Becker RS 《The journal of physical chemistry. A》2007,111(27):5948-5953
The widely investigated photobehaviors of 9-bromo and 9,10-di-bromoanthracenes have been revisited here to clarify the competition among different relaxation paths of their lowest two electronic excited states. The results obtained show that these two molecules exhibit a parallel photobehavior, which depends on the excited electronic and vibronic transition, the medium viscosity, and the temperature. The first electronic state of either of these does not exhibit photochemistry in fluid solution or rigid matrices (80 K). The fluorescence emission occurs with a very low quantum yield (approximately 10(-2)) at room temperature but with a very high quantum yield (0.9 to approximately 1) at 80 K. When exciting in the second electronic transition, the fluorescence intensity is lower than when exciting in S1 at both room temperature and low temperature due to competition with the observed photocleavage of the C-Br bond. The reaction yield decreases as the temperature decreases and depends on the viscosity of the solvent; the higher the viscosity, the lower the observed yield of photochemistry. Temperature and viscosity effects are a consequence of the fact that the radicals produced by C-Br bond breakage cannot escape from the solvent cage and, moreover, quickly recombine within the cage giving the appearance that no photochemistry occurred. The presence of photochemistry in S(2) and its absence in S(1) is principally due to the fact that S(2) has a pi,sigma* character in the C-Br bond, whereas the S(1) state has its origin from a pi,pi* delocalized configuration. 相似文献
195.
Cataldi TR Rubino A Lelario F Bufo SA 《Rapid communications in mass spectrometry : RCM》2007,21(14):2374-2388
A method for the comprehensive profiling of intact glucosinolates (GLSs), major and minor, occurring in leaves and seeds of rocket salad (Eruca sativa L.) is presented using optimized reversed-phase liquid chromatography (RP-LC) with electrospray ionization (ESI) ion trap mass spectrometry (ITMS). ESI-ITMS in the negative mode was confirmed to be very suitable to analyze these compounds in crude extracts. After extraction from the plant material with methanol/water (70:30 v/v) at 70 degrees C, the analytes of interest were separated on a C18 column using an eluent acidified with formic acid (0.1%) and modified with acetonitrile. All the GLSs found in leaves of rocket salad gave good signals corresponding to the deprotonated precursor ion, [M-H]-. Although the mass spectra also exhibited an analytically important non-covalent adduct ion at [2M-H]-, the structures of glucosinolates were confirmed by extensive sequential MS analysis, thereby substantially improving the identification of unknown compounds. The results obtained not only revealed in leaves of E. sativa at least twelve species of GLSs including seven aliphatic compounds (glucoraphanin with [M-H]- at m/z ratio of 436, glucoerucin at m/z 420, 4-mercaptobutyl-GLS at m/z 406, progoitrin/epiprogoitrin at m/z 388, sinigrin at m/z 358, 4-methylpentyl- and n-hexyl-GLS at m/z 402) and three indole glucosinolates (i.e., three N-heterocyclic compounds: 4-hydroxyglucobrassicin and 5-hydroxyglucobrassicin at m/z 463, and 4-methoxy-glucobrassicin at m/z 477), but also two structurally related compounds containing one intermolecular disulfide linkage (4-(beta-D-glucopyranosyldisulfanyl)butyl-GLS at m/z 600 and a dimeric 4-mercaptobutyl-GLS at m/z 811). This latter symmetric disulfide was previously considered as an artefact formed during extraction of GLSs from vegetative tissues. Glucosinolates were detected in the leaves with a wide range of contents (10-200 micromol/g) and a great variation in the composition. Only three GLSs were identified in seeds of rocket salad, namely glucoraphanin, glucoerucin and 4-methoxyglucobrassicin. As expected, the most abundant GLS in seeds is glucoerucin. The feasibility of the strategy was also demonstrated using a rapeseed extract of certified reference material (BCR367R). The results indicated the usefulness of this method for a rapid, sensitive and comprehensive profiling of the GLS family naturally occurring in extracts of crude plant matter. 相似文献
196.
Dal Piaz F De Leo M Braca A De Simone F De Tommasi N 《Rapid communications in mass spectrometry : RCM》2007,21(3):286-296
Glycoconjugates are a class of complex molecules that are widely distributed in the plant kingdom and in some marine organisms. This class of compounds has a wide range of biological activities such as anti-inflammatory, antimicrobial, antifungal, anticancer, antiulcer, and immunoenhancing actions.1-3 Some of them also show various toxic activities such as cytotoxic, hemolytic, cardiotoxic, and teratogenic. Among these compounds, steroidal and triterpenoid saponins have long been known as components of widely used herbal drugs and pharmaceutical preparations; ginseng, Tribulus terrestris, Quillaja saponaria, and Digitalis ssp. are just a few examples. Thus, identification of saponins in herbal drugs used worldwide is of significance in phytochemical and toxicological quality control studies, and for the production of safe health products. Therefore, there is continuing demand for methods to rapidly identify and characterize these natural products. 相似文献
197.
A new NIR method based on multivariate calibration for determination of ethanol in industrially packed wholemeal bread was developed and validated. GC-FID was used as reference method for the determination of actual ethanol concentration of different samples of wholemeal bread with proper content of added ethanol, ranging from 0 to 3.5% (w/w). Stepwise discriminant analysis was carried out on the NIR dataset, in order to reduce the number of original variables by selecting those that were able to discriminate between the samples of different ethanol concentrations. With the so selected variables a multivariate calibration model was then obtained by multiple linear regression. The prediction power of the linear model was optimized by a new “leave one out” method, so that the number of original variables resulted further reduced. 相似文献
198.
Gradinaru J Forni A Druta V Tessore F Zecchin S Quici S Garbalau N 《Inorganic chemistry》2007,46(3):884-895
New unsymmetrical [N2O2] tetradentate Schiff base complexes of Ni(II), Cu(II), Zn(II), and VO(II) were synthesized by template condensation of the tetradentate precursor 1-phenylbutane-1,3-dione mono-S-methylisothiosemicarbazone with o-hydroxybenzaldehyde or its 5-phenylazo derivative. They were characterized by elemental analysis, IR, UV-vis, electron spin resonance, and NMR spectroscopy, mass spectrometry, and magnetic measurements. The crystal structures of five of them have been determined by X-ray diffraction using, in some cases, synchrotron radiation. These compounds are characterized by a large thermal stability; their decomposition temperatures range from 240 up to 310 degrees C. Complexes with the phenylazo substituent were found to possess a large second-order nonlinear optical (NLO) response, as determined both by measurements of solution-phase direct current electric-field-induced second harmonic generation and by theoretical time-dependent density functional theory (TDDFT) calculations. The molecular hyperpolarizability was found to decrease in the order Zn(II) > Cu(II) > Ni(II) approximately VO(II). The active role of the metal in determining the NLO properties of the complexes was shown through an analysis of their UV-vis spectra, which revealed the presence of metal-to-ligand (in closed-shell complexes) and ligand-to-metal (in open-shell complexes) charge-transfer bands together with intra-ligand charge-transfer transitions. Assignment of the bands was based on the analysis of the TDDFT computed spectra. 相似文献
199.
The bis-triazole antifungal fluconazole (FCZ) is used in the systemic treatment of superficial mycoses. The inconvenience of drug interactions and incidence of adverse reactions occurs in approximately 16% of patients, despite several advantages against systemic fungal infections. Because its pharmacokinetics profile is favorable to cutaneous accumulation, it presents a prominent importance in the treatment of superficial mycoses. This study shows FCZ method validation by reversed-phase high-performance liquid chromatography in the linear range of 2 to 32 microg/mL, which suitable for application in biological matrices after topical permeation studies. The method is tested in simulated FCZ alcoholic solution applied to skin extracts after in vitro permeation studies using Franz cells. Recovery shows good results (in the range 75.0% +/- 4.1% to 82.0% +/- 6.6%) regarding the biological matrices. 相似文献
200.
New pyrroloisoquinoline-based tetrapeptides were synthesized in enantiomerically pure form, and their conformational features were studied by NMR, IR, and molecular-modeling techniques. The presence of a reverse turn was observed in both structures, with the C1 stereochemistry playing a central role in determining stable conformations. In particular, all of the analyses led to the conclusion that a type II' beta-turn is mostly stabilized in tetrapeptide mimic 3a, while a typical inverse gamma-turn geometry is revealed for the diastereoisomer 3b. 相似文献