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151.
    
A first catalytic preparation of the popular antiplatelet drug (S)-clopidogrel, known with the tradename of Plavix, has been developed in a one-pot and innovative approach. The synthesis can be performed using commercially available ortho-chlorobenzaldehyde, 1-naphthylsulfonyl acetonitrile, tert-butyl hydroperoxide (TBHP), 4,5,6,7-tetrahydrothieno[3,2-c]pyridine and 20 mol % of a quinidine derived organocatalyst in a single solvent. A Knoevenagel/asymmetric epoxidation/domino ring-opening esterification (DROE) sequence enabled to obtain (S)-clopidogrel in 61 % overall yield and 62 % ee. Fine optimization of the reaction conditions proved to be crucial to set up a selective and efficient process.  相似文献   
152.
    
Saffron is a spice obtained from the drying process of the stigmas of the flower Crocus sativus Linnaeus. It is well known that the organoleptic characteristics of this spice are closely linked to the production area and harvesting year. The present work aims to evaluate whether saffron samples produced in different years and origins present sensibly different crocin profiles. To achieve this goal, 120 saffron samples were harvested between 2016 and 2020 in four different Italian areas. The crocins were analysed, identified, and quantified by high-performance liquid chromatography–electrospray–tandem mass spectrometry (HPLC–ESI–MS/MS) in multiple reaction monitoring mode (MRM). Subsequently, ANOVA–simultaneous component analysis (ASCA) was used to evaluate whether the origin and annuity significantly affected the composition of the crocins. ASCA confirmed the relevance of these effects. Eventually, soft independent modelling by class analogy (SIMCA) models were created for each of the four different origins. Mixtures of saffron from different areas were also prepared to test the robustness of the models. SIMCA provided satisfying results; in fact, models provided 100% sensitivity for three origins (Cascia, Sardinia, and Città della Pieve) on the external test set (48 samples) and 88% (sensitivity on the external test set) for the Spoleto class.  相似文献   
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154.
    
In this work, POXC, a laccase from Pleurotus ostreatus, was immobilized on carbon nanotubes (CNTs) modified by electrografting anthraquinone and naphthoate diazonium salts. Thanks to a favorable interaction between laccase and covalently modified CNTs, this laccase exhibits high-potential/high-current oxygen reduction reaction (ORR) performances, surpassing the performances of the well-known laccase from Trametes versicolor (TvLAC) immobilized on the same nanostructured electrodes. Furthermore, immobilized POXC demonstrates high ORR activity over a wide range of pH (2 to 8), being also highly active at a gas-diffusion electrode. Finally, owing to these unique performances, this enzyme was able to operate at the interface of the microporous layer, humidified air and a polymer electrolyte, that is, Nafion®, in a conventional H2/air proton-exchange membrane fuel.  相似文献   
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156.
    
Electroactive nanocarbon can be defined as a carbon nanomaterial that contains electrochemically reducible oxygen functionalities. We show here how an electroactive nanocarbon material can work both as a platform and as a signal generator when developing an immunosensor for the detection of mycotoxins. The suitability of the material for the immobilization of the biorecognition element by the formation of multiple noncovalent interactions, and the concurrent ability to provide a significant reduction peak are combined here in a label-free, single-step immunosensor. The variation in the current intensity, owing to the reduction of the electroactive platform, is correlated to the electrochemical availability of the oxygen functionalities involved in the interaction with the biorecognition element first, and the antibody/antigen conjugate in the detection step. We demonstrated here a direct dependence between the signal generated from the electroactive nanocarbon platform and each step of the biorecognition event, which allows the selective and precise detection of the analyte under investigation.  相似文献   
157.
A comprehensive numerical tool has been developed for the evaluation of the performances of Radio over Fiber (RoF) links intended for wireless signal distribution.At the transmitter end an appropriate set of rate equations allows to model the optical source as a solitary laser or as an appropriately injection locked laser. The optical channel is modeled putting into account the combined effect of fiber dispersion, laser source non ideal performances (e.g. non-linear effects, frequency chirp), and quadratic detection of the receiving photodiode. The simulation model developed can be a useful tool at the design stage allowing a preliminary evaluation of the characteristics of real RoF links.  相似文献   
158.
Continuous-wave laser action at approximately 2 microm is demonstrated in a Tm-Ho:KYF4 single crystal at room temperature. Crystal growth, spectroscopic measurements, and laser results are presented. An output power in excess of 250 mW is obtained with a tuning range of 99 nm, the largest ever published, to our knowledge, for Tm-Ho in any crystalline host.  相似文献   
159.
160.
The interaction of water with Si- and C- terminated beta-SiC(001) surfaces was investigated by means of ab initio molecular dynamics simulations. Irrespective of coverage, varied from 1/4 to 1 monolayer, we found that water dissociates on the Si-terminated surface, substantially modifying the clean surface reconstruction, while the C-terminated surface is nonreactive and hydrophobic. Based on our results, we propose that STM images and photoemission experiments may detect specific changes induced by water on both the structural and electronic properties of SiC(001) surfaces.  相似文献   
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