Buchbesprechungen

Ohne ZusammenfassungDa die Zeitschrift Mikrochemie vereinigt mit Mikrochimica Acta vornehmlich zur Veröffentlichung von Originalarbeiten bestimmt und auch für diese eine knappe Darstellung erforderlich ist, um eine möglichst schnelle Publikation zu gewährleisten, können nur solche Bücher besprochen werden, deren Inhalt für die Mikrochemie von Interesse ist.     

Einen Probenehmer

Ohne Zusammenfassung     

Investigator® Argus X‐12 study on the population of Czech Republic: Comparison of linked and unlinked X‐STRs for kinship analysis

DNA samples of 523 unrelated anonymized individuals (307 males and 216 females) born and living in the Czech Republic were genotyped using Investigator® Argus X‐12 system in the following loci localized in four linkage groups: DXS10148, DXS10135, DXS8378, DXS7132, DXS10079, DXS10074, DXS10103, HPRTB, DXS10101, DXS10146, DXS10134, DXS742. Haplotype frequencies were calculated for each LG (Linkage Group). The frequency of most common haplotype was 0.016, 0.036, 0.042, and 0.023 for LG1, LG2, LG3, and LG4, respectively. The combined power of discrimination was more than 0.999999999 both for female and male samples. The mean exclusion chance was 0.99999999 (trios) and 0.999999 (duos). Informativity and suitability of Investigator® Argus X‐12 for kinship determination was assessed by computing in several female–female duos using LR (Likelihood Ratio) determination for autosomal STR (PowerPlex ESI‐17), linked (Investigator® Argus X‐12 system), and unlinked (X‐STR Decaplex) X‐STR kits. Investigator® Argus X‐12 proved to be very useful for sibship determination, since its LR values were relatively similar to LR for autosomal STR kit. This work presents the first population data for Investigator® Argus X‐12 system in the Czech Republic.     

Die mikrogravimetrische Trennung von Nickel und Uran

Ohne Zusammenfassung     

1,3-substituted imidazolidine-2,4,5-triones: synthesis and inhibition of cholinergic enzymes

A series of novel and highly active acetylcholinesterase and butyrylcholinesterase inhibitors derived from substituted benzothiazoles containing an imidazolidine-2,4,5-trione moiety were synthesized and characterized. The molecular structure of 1-(2,6-diisopropyl-phenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-imidazolidine-2,4,5-trione (3g) was determined by single-crystal X-ray diffraction. Both optical isomers are present as two independent molecules in the triclinic crystal system. The lipophilicity of the compounds was determined as the partition coefficient log K(ow) using the traditional shake-flask method. The in vitro inhibitory activity on acetylcholinesterase from electric eel and butyrylcholinesterase isolated from equine serum was determined. The inhibitory activity on acetylcholinesterase was significantly higher than that of the standard drug rivastigmine. The discussed compounds are also promising inhibitors of butyrylcholinesterase, as some of the prepared compounds inhibit butyrylcholinesterase better than the internal standards rivastigmine and galanthamine. The highest inhibitory activity (IC?? = 1.66 μmol/L) corresponds to the compound 1-(4-isopropylphenyl)-3-[(R)-1-(6-fluorobenzo[d]thiazol-2-yl)ethyl]imidazolidine-2,4,5-trione (3d). For all the studied compounds, the relationships between the lipophilicity and the chemical structure as well as their structure-activity relationships are discussed.