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排序方式: 共有248条查询结果,搜索用时 15 毫秒
221.
Salvador Padilla-Arellanes Rafael Salgado-Garciglia Marisol Bez-Magaa Alejandra Ochoa-Zarzosa Joel Edmundo Lpez-Meza 《Molecules (Basel, Switzerland)》2021,26(14)
Osteosarcoma is the most common malignant bone tumor in both children and dogs. It is an aggressive and metastatic cancer with a poor prognosis for long-term survival. The search for new anti-cancer drugs with fewer side effects has become an essential goal for cancer chemotherapy; in this sense, the bioactive compounds from avocado have proved their efficacy as cytotoxic molecules. The objective of this study was to determine the cytotoxic and antiproliferative effect of a lipid-rich extract (LEAS) from Mexican native avocado seed (Persea americana var. drymifolia) on canine osteosarcoma D-17 cell line. Also, the combined activity with cytostatic drugs was evaluated. LEAS was cytotoxic to D-17 cells in a concentration-dependent manner with an IC50 = 15.5 µg/mL. Besides, LEAS induced caspase-dependent cell apoptosis by the extrinsic and intrinsic pathways. Moreover, LEAS induced a significant loss of mitochondrial membrane potential and increased superoxide anion production and mitochondrial ROS. Also, LEAS induced the arrest of the cell cycle in the G0/G1 phase. Finally, LEAS improved the cytotoxic activity of cisplatin, carboplatin, and in less extension, doxorubicin against the canine osteosarcoma cell line through a synergistic effect. In conclusion, avocado could be a potential source of bioactive molecules in the searching treatments for osteosarcoma. 相似文献
222.
Albelda MT García-España E Jiménez HR Llinares JM Soriano C Sornosa-Ten A Verdejo B 《Dalton transactions (Cambridge, England : 2003)》2006,(37):4474-4481
The synthesis, characterization, Cu2+ coordination and interaction with AMP of three tripodal polyamines are reported. The polyamines are based on the structure of the tetraamine (tren) which has been enlarged with three propylamino functionalities (), with a further anthrylmethyl fragment at one of its terminal primary nitrogens () or with naphthylmethyl fragments at its three ends (). The protonation constants of all three polyamines show that at pH 6, all six primary and secondary nitrogen atoms in the arms are protonated. The interaction with Cu2+ and AMP (adenosine-5'-monophosphate) has been studied by potentiometric, UV-Vis, ESI-MS spectroscopy and NMR techniques. pH-Metric, NMR and ESI/MS techniques indicate that and form with AMP adducts of 1:1, 2:1 and 3:1 AMP:L stoichiometries in water. This is one of the first examples for the formation of such complexes in aqueous solution. Formation of ternary complexes between , , , Cu2+ and AMP is observed. Paramagnetic NMR techniques have been used to obtain structural information on the binding mode of AMP to the Cu2+- binuclear complexes. 相似文献
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225.
Moreno-Escobar J Puc-Carrillo A Cáceres-Farfán M Peña-Rodríguez LM Gamboa-Angulo MM 《Natural product research》2005,19(6):603-607
Bioassay-guided purification of the organic crude extract of Alternaria solani resulted in the isolation of three metabolites responsible for causing necrosis on potato leaves. These phytotoxins were identified as 2-(2",3"-dimethyl-but-1-enyl)-zinniol (1), 8-zinniol methyl ether (2). and 8-zinniol methyl ether based on their spectroscopic data (IR, MS, 1H and 13CNMR). Metabolites 1 and 2 have been identified as new phytotoxins structurally related to zinniol (4). Additionally, 5-(3',3'-dimethylallyloxy)-7-methoxy-6-methyl-phthalide and 8-zinniol-2-(phenyl)-ethyl ether (3) were also isolated during the purification process. 相似文献
226.
Molecular Encapsulation of Half-Sandwich Complexes of Iron with Cyclodextrins: New Laminar Materials
Carlos Díaz Alejandra Arancibia 《Journal of inclusion phenomena and macrocyclic chemistry》1998,30(2):127-141
The treatment of - and -cyclodextrins with the half-sandwich complexes of iron afford the inclusion compounds CpFe(L2)XCD ( and ) (X = Cl, I; L = CO; L2 = dppe, dppe = (Ph)2P(CH2)2P(Ph)2), [CpFe(L2)L-]PF6CD ( and ) L- neutral donor ligands and[(Cp(dppe)Fe)2-µ-CN]PF62CD ( and ). The inclusion compounds [Cp(dppe)Fe-NCCH3]PF6-CD and [Cp(dppe)Fe-(1-dppm)]PF6-CD have a laminar structure. The - and -cyclodextrin encapsulation effect on the electro-oxidation of the binuclear complex was studied using cyclic voltammetry.The electron-transfer reactions associated with the oxidation of the two different N-bonded and C-bonded organometallic fragments are substantially affected by and encapsulation. 相似文献
227.
Alexander Briceo Reinaldo Atencio Raquel Gil Alejandra Nobrega 《Acta Crystallographica. Section C, Structural Chemistry》2007,63(8):o441-o444
The structure of trans‐3‐(3‐pyridyl)acrylic acid, C8H7NO2, (I), possesses a two‐dimensional hydrogen‐bonded array of supramolecular ribbons assembled via heterodimeric synthons between the pyridine and carboxyl groups. This compound is photoreactive in the solid state as a result of close contacts between the double bonds of neighbouring molecules [3.821 (1) Å] along the a axis. The crystal structure of the photoproduct, rctt‐3,3′‐(3,4‐dicarboxycyclobutane‐1,2‐diyl)dipyridinium dichloride, C16H16N2O42+·2Cl−, (II), consists of a three‐dimensional hydrogen‐bonded network built from crosslinking of helical chains integrated by self‐assembly of dipyridinium cations and Cl− anions via different O—H...Cl, C—H...Cl and N+—H...Cl hydrogen‐bond interactions. 相似文献
228.
Alejandra Salerno Vanina Ceriani Isabel A. Perillo 《Journal of heterocyclic chemistry》1992,29(7):1725-1733
Reactions of several substituted 1H-4,5-dihydroimidazolium salts 1 with nucleophilic and electrophilic reducing agents acting via hydride transfer were explored. Reaction of compounds 1 with lithium aluminum hydride in THF afforded the corresponding imidazolidines 2 . When alkaline borohydrides (sodium borohydride, potassium borohydride, sodium cyanoborohydride) in ethanol at room temperature were used, partial or total over-reduction of compounds 2 leading to N,N,N'-trisubstituted ethylenediamines took place on occasion. Results may be explained taking into account that reductive cleavage of 2 proceeds via a stabilized iminium ion present in protic solvents. Treatment of compounds 1 with an excess of borane in THF afforded the corresponding imidazolidines 2 or their borane complexes, according to the substituent type. 相似文献
229.
A. T. Seyhan Alejandra de la Vega M. Tanoglu K. Schulte 《Journal of Polymer Science.Polymer Physics》2009,47(15):1511-1522
This study aims to investigate the curing behavior of a vinyl ester‐polyester resin suspensions containing 0.3 wt % of multiwalled carbon nanotubes with and without amine functional groups (MWCNTs and MWCNT‐NH2). For this purpose, various analytical techniques, including Differential Scanning Calorimetry (DSC), Fourier infrared spectroscopy (FTIR), Raman Spectroscopy, and Thermo Gravimetric Analyzer (TGA) were conducted. The resin suspensions with carbon nanotubes (CNTs) were prepared via 3‐roll milling technique. DSC measurements showed that resin suspensions containing CNTs exhibited higher heat of cure (Q), besides lower activation energy (Ea) when compared with neat resin. For the sake of simplicity of interpretation, FTIR investigations were performed on neat vinyl ester resin suspensions containing the same amount of CNTs as resin. As a result, the individual fractional conversion rates of styrene and vinyl ester were interestingly found to be altered dependent on MWCNTs and MWCNT‐NH2. The findings obtained from RS measurements of the cured samples are highly proportional to those obtained from FTIR measurements. TGA measurements revealed that CNT modified nanocomposites have higher activation energy of degradation (Ed) compared with the cured polymer. The findings obtained revealed that CNTs with and without amine functional groups alter overall thermal curing response of the surrounding matrix resin, which may probably impart distinctive characteristics to mechanical behavior of the corresponding nanocomposites achieved. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 1511–1522, 2009 相似文献
230.
Luciano Zunino Miguel C. Soriano Alejandra Figliola Darío G. Prez Mario Garavaglia Claudio R. Mirasso Osvaldo A. Rosso 《Optics Communications》2009,282(23):4587-4594
From the estimation of the Hurst exponent and the multifractality degree we discriminate the security levels of two typical encoding schemes usually applied in chaos-based communication systems. We also analyze the effects that the sampling period and the message amplitude have on the goodness of these techniques. We compare our results with those obtained by considering an information theory approach [O.A. Rosso, R. Vicente, C.R. Mirasso, Phys. Lett. A 372 (2007) 1018]. The Hurst exponent seems to be a sensitive and powerful tool for discriminating the presence of a message embedded in a chaotic carrier. 相似文献