全文获取类型
收费全文 | 5751篇 |
免费 | 199篇 |
国内免费 | 42篇 |
专业分类
化学 | 3764篇 |
晶体学 | 20篇 |
力学 | 194篇 |
数学 | 1060篇 |
物理学 | 954篇 |
出版年
2023年 | 32篇 |
2022年 | 115篇 |
2021年 | 106篇 |
2020年 | 119篇 |
2019年 | 114篇 |
2018年 | 118篇 |
2017年 | 82篇 |
2016年 | 221篇 |
2015年 | 178篇 |
2014年 | 226篇 |
2013年 | 356篇 |
2012年 | 399篇 |
2011年 | 407篇 |
2010年 | 213篇 |
2009年 | 245篇 |
2008年 | 336篇 |
2007年 | 337篇 |
2006年 | 285篇 |
2005年 | 266篇 |
2004年 | 249篇 |
2003年 | 178篇 |
2002年 | 155篇 |
2001年 | 84篇 |
2000年 | 74篇 |
1999年 | 51篇 |
1998年 | 61篇 |
1997年 | 67篇 |
1996年 | 64篇 |
1995年 | 46篇 |
1994年 | 58篇 |
1993年 | 52篇 |
1992年 | 68篇 |
1991年 | 45篇 |
1990年 | 39篇 |
1989年 | 40篇 |
1988年 | 36篇 |
1987年 | 33篇 |
1986年 | 21篇 |
1985年 | 62篇 |
1984年 | 48篇 |
1983年 | 46篇 |
1982年 | 41篇 |
1981年 | 23篇 |
1980年 | 25篇 |
1979年 | 15篇 |
1978年 | 28篇 |
1977年 | 22篇 |
1976年 | 21篇 |
1974年 | 14篇 |
1967年 | 8篇 |
排序方式: 共有5992条查询结果,搜索用时 0 毫秒
111.
A potential energy surface for the ground electronic state of the Ar-HI van der Waals complex is calculated at the coupled-cluster with single and double excitations and a noniterative perturbation treatment of triple excitations [CCSD(T)] level of theory. Calculations are performed using for the iodine atom a correlation consistent triple-zeta valence basis set in conjunction with large-core Stuttgart-Dresden-Bonn relativistic pseudopotential, whereas specific augmented correlation consistent basis sets are employed for the H and Ar atoms supplemented with an additional set of bond functions. In agreement with previous studies, the equilibrium structure is found to be linear Ar-I-H, with a well depth of 205.38 cm(-1). Another two secondary minima are also predicted at a linear and bent Ar-H-I configurations with well depths of 153.57 and 151.57 cm(-1), respectively. The parametrized CCSD(T) potential is used to calculate rovibrational bound states of Ar-HI/Ar-DI complexes, and the vibrationally averaged structures of the different isomers are determined. Spectroscopic constants are also computed from the CCSD(T) surface and their comparison with available experimental data demonstrates the quality of the present surface in the corresponding configuration regions. 相似文献
112.
Thierry Wesley de Albuquerque Aguiar Jos Josenildo Batista Silvio Assis de Oliveira Ferreira Maíra de Vasconcelos Lima Sampaio Dewson Rocha Pereira Magda Rhayanny Assuno Ferreira Luiz Alberto Lira Soares Ana Maria Mendona de Albuquerque Melo Mnica Camelo Pessoa de Azevedo Albuquerque Andr de Lima Aires Hallysson Douglas Andrade de Araújo Luana Cassandra Breitenbach Barroso Coelho 《Molecules (Basel, Switzerland)》2022,27(15)
Biomphalaria glabrata snails constitute the main vector of schistosomiasis in Brazil, and Bauhinia monandra Kurz, the leaves of which contain BmoLL lectin with biocidal action, is a plant widely found on continents in which the disease is endemic. This work describes the composition of B. monandra preparations and the effect on embryos and adult snails, their reproduction parameters and hemocytes. We also describe the results of a comet assay after B. glabrata exposure to sublethal concentrations of the preparations. Additionally, the effects of the preparations on S. mansoni cercariae and environmental monitoring with Artemia salina are described. In the chemical evaluation, cinnamic, flavonoid and saponin derivatives were detected in the two preparations assessed, namely the saline extract and the fraction. Both preparations were toxic to embryos in the blastula, gastrula, trochophore, veliger and hippo stages (LC50 of 0.042 and 0.0478; 0.0417 and 0.0419; 0.0897 and 0.1582; 0.3734 and 0.0974; 0.397 and 0.0970 mg/mL, respectively) and to adult snails (LC50 of 6.6 and 0.87 mg/mL, respectively), which were reproductively affected with decreased egg deposition. In blood cell analysis, characteristic cells for apoptosis, micronucleus and binucleation were detected, while for comet analysis, different degrees of nuclear damage were detected. The fraction was able to cause total mortality of the cercariae and did not present environmental toxicity. Therefore, B. monandra preparations are promising in combating schistosomiasis since they can control both the intermediate host and eliminate the infectious agent, besides being safe to the environment. 相似文献
113.
Irene Dini Vittoria Alborino Stefania Lanzuise Nadia Lombardi Roberta Marra Anna Balestrieri Alberto Ritieni Sheridan L. Woo Francesco Vinale 《Molecules (Basel, Switzerland)》2022,27(12)
The contamination of agricultural products with mycotoxins causes risks to animal and human health and severe economic losses. Mycotoxicoses can be reduced by preventing fungal infection using chemical and biological approaches. The chemical strategies can release toxic molecules; therefore, strategies for biological control are being evaluated, such as using nontoxic fungi and their metabolites. This work evaluated the effect of exoenzymes produced by the beneficial fungus Trichoderma afroharzianum strain T22 in degrading Aflatoxin B1 (AFB1) and Ochratoxin A (OTA). The ability of Trichoderma to produce hydrolases was stimulated by using different inducing substrates. The highest AFB1 and OTA degradation activity was obtained using a medium containing lyophilized mushrooms and crude fiber. The T. afroharzianum T22’s ability to reduce mycotoxins may be attributed to peroxidase enzymes. This study showed that T. afroharzianum strain T22 or its peroxidase supplementation could represent a sustainable strategy for the degradation of AFB1 and OTA in feed and food products. 相似文献
114.
Roberto del Río-Rodríguez Lorena Fragoso-Jarillo Alberto F. Garrido-Castro M. Carmen Maestro Jose A. Fernndez-Salas Jos Alemn 《Chemical science》2022,13(22):6512
Herein, we report, a general, facile and environmentally friendly Minisci-type alkylation of N-heteroarenes under simple and straightforward electrochemical conditions using widely available alkyl halides as radical precursors. Primary, secondary and tertiary alkyl radicals have been shown to be efficiently generated and coupled with a large variety of N-heteroarenes. The method presents a very high functional group tolerance, including various heterocyclic-based natural products, which highlights the robustness of the methodology. This applicability has been further proved in the synthesis of various interesting biologically valuable building blocks. In addition, we have proposed a mechanism based on different proofs and pieces of electrochemical evidence.Herein, we report, a general, facile and environmentally friendly Minisci-type alkylation of N-heteroarenes under simple and straightforward electrochemical conditions using widely available alkyl halides as radical precursors. 相似文献
115.
Pierre Beaujean Lionel Sanguinet Vincent Rodriguez Frdric Castet Benoît Champagne 《Molecules (Basel, Switzerland)》2022,27(9)
This contribution employs quantum chemistry methods to describe the variations of the second nonlinear optical responses of molecular switches based on benzazolo-oxazolidine (BOX) units, connected by π-linkers, along their successive opening/closing. Under the fully closed forms, all of them display negligible first hyperpolarizability (β) values. When one BOX is opened, which is sketched as C→O, a push–pull π-conjugated segment is formed, having the potential to enhance β and to set the depolarization ratio (DR) to its one-dimensional-like value (DR = 5). This is observed when only one BOX is open, either for the monoBOX species (C→O) or for the diBOX (CC→CO) and triBOX (CCC→CCO) compounds, i.e., when the remaining BOXs stay closed. The next BOX openings have much different effects. For the diBOXs, the second opening (CO→OO) is associated with a decrease of β, and this decrease is tuned by controlling the conformation of the π-linker, i.e., the centrosymmetry of the whole compound because β vanishes in centrosymmetric compounds. For the triBOXs, the second opening gives rise to a Λ-shape compound, with a negligible change of β, but a decrease of the DR whereas, along the third opening, β remains similar and the DR decreases to the typical value of octupolar systems (DR = 1.5). 相似文献
116.
The capability of certain heavy metal ions to induce fluorescence decrease by a quenching mechanism suggested us to design
and build a sensor potentially tunable for different ions at different concentrations. We propose a quenching-based sensor
exploiting a nanostructured architecture in which fluorescent molecules (the sensing probe) are entrapped to recognize a specific
analyte (heavy metal ions) through an optical transduction. The polyelectrolyte nanostructured system, named nanocapsule,
improves the fluorophore-ion quenching sensitivity allowing a micromolar detection. Furthermore we couple our sensor with
an electrical device in order to refine the sensing procedure: the electric field created allows a metal ions spatial gradient,
necessary to detect a specific element on a single sample solution, avoiding a comparative analysis with an intensity reference
value. Results obtained will show the advantages and the potentialities of our system as a smart toolbox for metal ions detection. 相似文献
117.
Alberto Blzquez-Moraleja Ines Senz-de-Santa María María D. Chiara Delia lvarez-Fernndez Inmaculada García-Moreno Ruth Prieto-Montero Virginia Martínez-Martínez Iigo Lpez Arbeloa Jose Luis Chiara 《Chemical science》2020,11(4):1052
The first fluorescent probes that are actively channeled into the mitochondrial matrix by a specific mitochondrial membrane transporter in living cells have been developed. The new functional probes (BCT) have a minimalist structural design based on the highly efficient and photostable BODIPY chromophore and carnitine as a biotargeting element. Both units are orthogonally bonded through the common boron atom, thus avoiding the use of complex polyatomic connectors. In contrast to known mitochondria-specific dyes, BCTs selectively label these organelles regardless of their transmembrane potential and in an enantioselective way. The obtained experimental evidence supports carnitine–acylcarnitine translocase (CACT) as the key transporter protein for BCTs, which behave therefore as acylcarnitine biomimetics. This simple structural design can be readily extended to other structurally diverse starting F-BODIPYs to obtain BCTs with varied emission wavelengths along the visible and NIR spectral regions and with multifunctional capabilities. BCTs are the first fluorescent derivatives of carnitine to be used in cell microscopy and stand as promising research tools to explore the role of the carnitine shuttle system in cancer and metabolic diseases. Extension of this approach to other small-molecule mitochondrial transporters is envisaged.A BODIPY derivative of carnitine enters mitochondria regardless of their membrane potential and in an enantioselective way through a specific mitochondrial membrane transporter in living cells. 相似文献
118.
Alberto Vezzani 《Journal of Pure and Applied Algebra》2019,223(2):818-843
We define a de Rham cohomology theory for analytic varieties over a valued field of equal characteristic p with coefficients in a chosen untilt of the perfection of by means of the motivic version of Scholze's tilting equivalence. We show that this definition generalizes the usual rigid cohomology in case the variety has good reduction. We also prove a conjecture of Ayoub yielding an equivalence between rigid analytic motives with good reduction and unipotent algebraic motives over the residue field, also in mixed characteristic. 相似文献
119.
ABSTRACT In this paper, we present a systematic roadmap for developing a robust and parallel multi-material reactive hydrodynamic solver that integrates historically stable algorithms with new and current modern methods to solve explosive system design problems. The Ghost Fluid Method and Riemann solvers were used to enforce appropriate interface boundary conditions. Improved performance in terms of computational work and convergence properties was achieved by modifying a local node sorting strategy that decouples ghost nodes, allowing us to set material boundary conditions via an explicit procedure, removing the need to solve a coupled system of equations numerically. The locality and explicit nature of the node sorting concept allows for greater levels of parallelism and lower computational cost when populating ghost nodes. Non-linear numerical issues endemic to the use of real Equations of State in hydro-codes were resolved by using more thermodynamically consistent forms allowing us to accurately resolve large density gradients associated with high energy detonation problems at material interfaces. Pre-computed volume tables were implemented adding to the robustness of the solver base. 相似文献
120.