Quasi-free divisors and duality

We prove a duality theorem for some logarithmic $\text{D}$-modules associated with a class of divisors. We also give some results for the locally quasi-homogeneous case. To cite this article: F.J. Castro-Jiménez, J.M. Ucha-Enr??quez, C. R. Acad. Sci. Paris, Ser. I 338 (2004).     

An iterative procedure for differential analysis of gene expression

Microarrays are a popular technology to study genes that are differentially expressed between two conditions. In this Note, we propose an iterative procedure to determine the biggest subset of non-differentially expressed genes. We prove a pseudo Markov relationship that allows practical computations. We obtain explicit expressions for FDR and the level of the proposed test at each step. To cite this article: A. Bar-Hen, S. Robin, C. R. Acad. Sci. Paris, Ser. I 337 (2003).     

Photonic crystals--a step towards integrated circuits for photonics.

The field of photonic crystals has, over the past few years, received dramatically increased attention. Photonic crystals are artificially engineered structures that exhibit a periodic variation in one, two, or three dimensions of the dielectric constant, with a period of the order of the pertinent light wavelength. Such structures in three dimensions should exhibit properties similar to solid-state electronic crystals, such as bandgaps, in other words wavelength regions where light cannot propagate in any direction. By introducing defects into the periodic arrangement, the photonic crystals exhibit properties analogous to those of solid-state crystals. The basic feature of a photonic bandgap was indeed experimentally demonstrated in the beginning of the 1990s, and sparked a large interest in, and in many ways revitalized, photonics research. There are several reasons for this attention. One is that photonic crystals, in their own right, offer a proliferation of challenging research tasks, involving a multitude of disciplines, such as electromagnetic theory, nanofabrication, semi-conductor technology, materials science, biotechnology, to name a few. Another reason is given by the somewhat more down-to-earth expectations that photonics crystals will create unique opportunities for novel devices and applications, and contribute to solving some of the issues that have plagued photonics such as large physical sizes, comparatively low functionality, and high costs. Herein, we will treat some basics of photonic crystal structures and discuss the state-of-the-art in fabrication as well give some examples of devices with unique properties, due to the use of photonic crystals. We will also point out some of the problems that still remain to be solved, and give a view on where photonic crystals currently stand.     

Two Stage Solid Phase Extraction with Subsequent HPLC Isolation for Structure Elucidation of Major Metabolites of (+)-(R)-2-{3-(benzo[1,4]dioxan-2-yl-methylamino)-1-propyl}-3(2H)-pyridazinone (GYKI-16084)

GYKI-16084 – (+)-(R)-2-{3-(benzo[1,4]dioxan-2-yl-methylamino)-1-propyl}-3(2H)-pyridazinone hydrochloride – is a new drug candidate for the treatment of benign prostatic hyperplasia. In our study the major metabolites formed in the rat and dog were isolated from dog and rat urine, then their structures were elucidated by means of MS and NMR. A two stage solid phase extraction (SPE) procedure and a semi-preparative HPLC method were developed utilizing various mechanisms of separation. The major metabolites proved to be isomeric glucuronides of the benzodioxane moiety hydroxylated at positions 6 or 7 and {2-(2-carboxyethyl)-3(2H)-pyridazinone}.     

Pointwise gradient estimates of solutions to onedimensional nonlinear parabolic equations

We present here an improved version of the method introduced by the first author to derive pointwise gradient estimates for the solutions of one-dimensional parabolic problems. After considering a general qualinear equation in divergence form we apply the method to the case of a nonlinear diffusion-convection equation. The conclusions are stated first for classical solutions and then for generalized and mild solutions. In the case of unbounded initial datum we obtain several regularizing effects for t > 0. Some unilateral pointwise gradient estimates are also obtained. The case of the Dirichlet problem is also considered. Finally, we collect, in the last section, several comments showing the connections among these estimates and the study of the free boundaries associated to the solutions of the diffusion-convection equation.     

Stable boundary layers in a diffusion problem with nonlinear reaction at the boundary

We prove the existence of nonconstant stable stationary solutions of an evolution problem with a nonlinear reaction acting on the boundary. These solutions present layers at certain points of the boundary. We also study the behavior of these solutions as the small parameter appearing in the equation approaches zero and show some stability properties of the profiles given by these equilibrium solutions.     

Optimized Method for the Determination of Prednisolone, Zn-Bacitracin and Phenylephrine in Local Pharmaceutical Preparations by Micellar Electrokinetic Capillary Chromatography

Summary A new, rapid and simple method is described and applied to resolve and quantify mixtures of prednisolone, Zn-bacitracin and phenylephrine. The determination was accomplished by MEKC. The separation was carried out at 25 °C and 30 kV, using a 5 mM phosphate-5 mM borate buffer (pH=8.2), 40 mM SDS as background electrolyte. Under these conditions, the run time was 6.6 min and the limits of quantification were about 1.0 mg L^–1 for every component. Repeatability and reproducibility studies were achieved showing no significant differences at 95% confidence level. The MEKC method has been applied for quantifying these compounds in different commercials pharmaceuticals products, without separations steps.