Synthesis of 3,3′-methylenebis(4-hydroxyquinolin-2(1H)-ones) of prospective anti-COVID-19 drugs

Molecular Diversity - During formylation of 2-quinolones by DMF/Et3N mixture, the unexpected 3,3′-methylenebis(4-hydroxyquinolin-2(1H)-ones) were formed. The discussed mechanism was proved as...     

Spectrophotometric quantification of fluoxetine hydrochloride: Application to quality control and quality assurance processes

Simple and rapid spectrophotometric methods have been developed for the microdetermination of fluoxetine HCl. The proposed methods are based on the formation of ion-pair complexes between fluoxetine and bromophenol blue (BPB), bromothymol blue (BTB), bromocresol green (BCG), and bromocresol purple (BCP) which can be measured at optimum λ_max. Optimization of reaction conditions was investigated. Beerșs law was obeyed in the concentration ranges of 0.5–8.0 μg mL⁻¹, whereas optimum concentration as adopted from the Ringbom plots was 0.7–7.7 μg mL⁻¹. The molar absorptivity, Sandell sensitivity, and detection limit were also calculated. The most optimal and sensitive method was developed using BCG. The correlation coefficient was 0.9988 (n = 6) with a relative standard deviation of 1.25, for six determinations of 4.0 μg mL⁻¹. The proposed methods were successfully applied to the determination of fluoxetine hydrochloride in its dosage forms and in biological fluids (spiked plasma sample) using the standard addition technique.     

Application of non-steroidal anti-inflammatory drugs for palladium determination

A highly sensitive spectrophotometric method for palladium determination using piroxicam and tenoxicam as new chromogenic reagents has been developed. In the presence of sodium lauryl sulfate (SLS), palladium reacts with piroxicam (PX) or tenoxicam (TX) to form stable yellow orange complexes in an acetate buffer solution of pH 5.0 at 424 nm and 426 nm with molar absorptivity of 7.16 × 10⁴ L mol⁻¹ cm⁻¹ and 1.20 × 10⁵ L mol⁻¹ cm⁻¹, respectively. Sandell sensitivity, detection, and quantitation limits were also calculated. Optimum conditions were evaluated considering pH, reagent concentration, time, temperature, and surfactant concentration. The complex system conforms to Beer’s law over the range of 0.07–1.28 μg mL⁻¹ palladium. The stoichiometric ratio and stability constant were also evaluated. Tolerance limits of many cations and anions were determined. Finally, the proposed method was applied successfully in the determination of palladium in jewellery, anode mud, synthetic mixtures, catalysts, and alloy samples.     

Z-scan measurement for the nonlinear absorption and the nonlinear refraction of poly1,4-diazophenylene-bridged-tris(8-hydroxy-quinoline) aluminum (PDPAlq3)

The nonlinear optical properties of the poly1,4-diazophenylene-bridged-tris(8-hydroxy-quinoline) aluminum (PDPAlq₃) solution were studied using single beam Z-scan technique with a continuous-wave Diode laser radiation at 657.2 nm with 10 Hz repetition rate. The results show that the solution of PDPAlq₃ exhibits large nonlinear refractive index (n₂ = −1.7642 × 10⁻¹² m²/W) and nonlinear absorption coefficient (β = 1.12 × 10⁻⁶ m/W). The negative sign of the nonlinear refractive index n₂ indicates that the material exhibits self-defocusing optical nonlinearity. The evaluation of the figure of merit (W = 1.8) shows that the solution of PDPAlq₃ is sufficient for application in all-optical switching technology. These results show that the solution of PDPAlq₃ have potential application in nonlinear optics.     

Kinetics and mechanism of oxidation of N,N-bis(salicylaldehyde-1,2-diaminoethane) cobalt(II) by N-bromosuccinimide in aqueous acidic medium

The kinetics of oxidation of N,N-bis(salicylaldehyde-1,2-diaminoethane) cobalt(II) complex by N-bromosuccinimide (NBS) in aqueous acid and H₂O–MeOH solvent mixtures were studied spectrophotometrically over the 20–40 °C range, 0.1–0.5 mol dm^?3 ionic strength, 2.2–2.8 pH range and 0–40 wt% MeOH–H₂O solvent mixtures for a range of NBS and complex concentrations. The rate shows first-order dependence on both [NBS] and [complex] and decreases with pH over the range studied. The protonated form of N-bromosuccinimide was identified as the main reactive species. An inner-sphere mechanism involving free radicals is proposed.     

Cytotoxic cembranoids from the Red Sea soft coral Sarcophyton glaucum

One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7alpha,8beta-dihydroxydeepoxysarcophine (2), 7beta-acetoxy-8alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7beta-Acetoxy-8alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 microg/mL, respectively.     

A Spectrophotometric Method for the Determination of Buclizine Hydrochloride Using the Charge-Transfer Spectrum of Buclizine-Iodine Complex

Abstract

A simple and sensitive spectrophotometric method is described for the determination of buclizine hydrochloride in bulk and tablets form. The method is based on the formation of charge-transfer complex between buclizine, as n-donor, and iodine, as Δ acceptor, which measured spectrophotometrically at 295 and 355 nm. A Job's plot indicated a 1:1 complex between the drug and iodine and Beer's law was obeyed in a concentration range of 4–30 μg ml^?1. A more detailed investigation of the complex was made with respect to its association constant and the free energy change. The method is simple and sensitive and has been applied successfully to the analysis of laboratory-made tablets without any interference from the tablet excipients. To validate the method, the results obtained were compared statistically with a newly developed uv-derivative spectrophotometric method. The charge-transfer method was favored due to its higher sensitivity, cheap coast and available equipments.     

Solvent and substituent effects on spectroscopical changes of some diazoaminobenzene derivatives

A series of diazoaminobenzene derivatives (seven) in which the substituents have a wide range of electronic characters are set out to understand the involvement of the substituent identity in controlling the changes in their electronic absorption spectra. The interactions between the diazoamino group and the different groups account for some spectral shifts. The UV-vis spectrum of each compound is measured in several solvents with wide variations of solvent polarity parameters to examine the role of the chemistry of the solvent in these spectroscopical changes. The electronic transitions are assigned and the solvent induced spectral shifts are analyzed in relation to the different solute-solvent interaction mechanisms using computational chemistry. The regression analysis is applied for correlating the different parameters. The results help to assign the solute-solvent interactions and the solvatochromic potential of the investigated compounds. It is concluded that the electronic character of the substituent and the chemical nature of the solvent are the major factors for the observed solvatochromism.     

Remarks on the asymptotic behavior of scalar auxiliary variable (SAV) schemes for gradient-like flows

We introduce a time semi-discretization of a damped wave equation by a SAV scheme with second order accuracy. The energy dissipation law is shown to hold without any restriction on the time step. We prove that any sequence generated by the scheme converges to a steady state (up to a subsequence). We notice that the steady state equation associated to the SAV scheme is a modified version of the steady state equation associated to the damped wave equation. We show that a similar result holds for a SAV fully discrete version of the Cahn-Hilliard equation and we compare numerically the two steady state equations.     

Thermally and optically induced effects on sub-band gap absorption in nanocrystalline CdSe (nc-CdSe) thin films

Nanocrystalline cadmium selenide (nc-CdSe) thin films have been prepared by thermal evaporation using the inert gas condensation (IGC) technique. Transmission electron microscopy (TEM) studies show that the CdSe nanocrystals (NCs) are spherical in shape. Constant photocurrent method (CPM) is used to determine the value of absorption coefficient in low absorption region of as-deposited, annealed and light soaked nc-CdSe thin films. Values of optical band gap (E_g) have been determined by using Tauc's relation for as-deposited, annealed and light soaked nc-CdSe thin films from the α values evaluated from reflection and transmission measurements. We have used a derivative procedure to sub-gap absorption spectra in order to get information on the energetic distribution of the occupied density of states below Fermi level. Constants such as optical gap E_g, Urbach edge E_u have been obtained from CPM spectra in as-deposited, annealed and light soaked nc-CdSe thin films. Concentration of defect states has also been calculated in as-deposited, annealed and light soaked nc-CdSe thin films.