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81.
We report isomer-pure synthesis of thieno[2,3-f:5,4-f ']bis[1]benzothiophene and thieno[3,2-f:4,5-f ']bis[1]benzothiophene, the anti and syn isomers of a pentacyclic compound consisting of alternating thiophene and benzene rings. The optical and electrochemical properties of both are reported. In the anti isomer, the ribbonlike embedding of three thiophene units leads to a near-planar molecule with favorable pi-pi stacking behavior in the solid state as shown by X-ray crystal structure analysis. 相似文献
82.
Structural Chemistry - Noncovalent interactions involving halogen bonding interactions, one of the emerging interactions due to its directionality, have been a subject of interest for various... 相似文献
83.
Obesity is the worst health risk worldwide, which is linked to a number of diseases. Pancreatic lipase is considered as an affective cause of obesity and can be a major target for controlling the obesity. The present study was designed to find out best phytochemicals against pancreatic lipase through molecular docking combined with molecular dynamics (MD) simulation. For this purpose, a total of 3770 phytochemicals were docked against pancreatic lipase and ranked them on the basis of binding affinity. Finally, 10 molecules (Kushenol K, Rosmarinic acid, Reserpic acid, Munjistin, Leachianone G, Cephamycin C, Arctigenin, 3-O-acetylpadmatin, Geniposide and Obtusin) were selected that showed strong bonding with the pancreatic lipase. MD simulations were performed on top five compounds using AMBER16. The simulated complexes revealed stability and ligands remained inside the binding pocket. This study concluded that these finalised molecules can be used as drug candidate to control obesity. 相似文献
84.
Hacer Azak Firat Baris Barlas Huseyin Bekir Yildiz Kadri Gulec Bilal Demir Dilek Odaci Demirkol Suna Timur 《Macromolecular bioscience》2016,16(4):545-552
Here, postfunctionalization and bioapplication of a π‐conjugated polymer named 4‐[4H‐dithieno(3,2‐b:2′,3′‐d)pyrrol‐4‐yl]aniline (DTP‐aryl‐NH2) are reported, which is successfully synthesized via electropolymerization onto the glassy carbon electrode. Folic acid (FA) is used to modify the amino functional polymer via N‐(3‐dimethylaminopropyl)‐N′‐ethylcarbodiimide hydrochloride/N‐hydroxysuccinimide chemistry for the further steps. The selective adhesion of folate receptor positive cells on the surface is followed by the electrochemical methods. Cyclic voltammetry and electrochemical impedance spectroscopy have been used to characterize stepwise modification of the electroactive surface. After optimization studies such as scan rate during the polymer deposition, FA amount for the efficient surface targeting, incubation time with the cells etc., analytical characterization is carried out. The surface morphologies at each step are imaged by using fluorescence microscopy.
85.
Adel Bilal 《Letters in Mathematical Physics》1994,32(2):103-120
We prove the recently conjectured relation between the 2 × 2-matrix differential operatorL = 2 –U and a certain nonlinear and nonlocal Poisson bracket algebra (V-algebra), containing a Virasoro subalgebra, which appeared in the study of a non-Abelian Toda field theory. In particular, we show that thisV-algebra is precisely given by the second Gelfand-Dikii bracket associated withL. The Miura transformation that relates the second to the first Gelfand-Dikii bracket is given. The two Gelfand-Dikii brackets are also obtained from the associated (integro-) differential equation satisfied by fermion bilinears. The asymptotic expansion of the resolvent of (L -) = 0 is studied and its coefficientsR
l yield an infinite sequence of Hamiltonians with mutually vanishing Poisson brackets. We recall how this leads to a matrix KdV hierarchy, which here are flow equations for the three component fieldsT,V
+,V
– ofU. ForV
± = 0, they reduce to the ordinary KdV hierarchy. The corresponding matrix mKdV equations are also given, as well as the relation to the pseudo-differential operator approach. Most of the results continue to hold ifU is a Hermitiann ×n matrix. Conjectures are made aboutn ×n-matrix,mth-order differential operatorsL and associatedV
(n,m)-algebras. 相似文献
86.
Muhammad Ajaz Hussain Anqa Zarish Khawar Abbas Muhammad Sher Muhammad Nawaz Tahir Wolfgang Tremel Muhammad Amin Abdul Ghafoor Bilal Ahmad Lodhi 《Cellulose (London, England)》2013,20(2):717-725
This article presents synthesis of novel macromolecular prodrugs of aceclofenac (an anti-inflammatory drug) onto hydroxypropylcellulose (HPC). The HPC-aceclofenac conjugates were prepared using an acylating agent 1,1′-carbonyldiimidazole (CDI) under homogenous reaction conditions. Aceclofenac was first activated by using CDI to form its N-acylimidazole. The N-acylimidazole of aceclofenac was then reacted with HPC polymer at 80 °C for 24 h. Highly pure prodrugs of aceclofenac were synthesized with a wide range of moderate to high degree of substitution (DS 0.41–2.12) as calculated by 1H NMR spectroscopy. The UV spectroscopic analysis has also revealed that the active drug aceclofenac was found in different conjugates from 28 to 67 mg/100 mg of HPC-aceclofenac conjugates which are in good agreement with DS calculated by 1H NMR spectroscopy. The gel permeation chromatography showed unimodal absorption that indicates no significant degradation in polymer chains during the reaction. The macromolecular prodrugs of aceclofenac were characterized using different spectroscopic and chromatographic techniques. The thermal analysis has revealed that HPC-aceclofenac conjugates (prodrugs) are 92 and 96 °C more stable than pure aceclofenac regarding their initial (Tdi) and maximum degradation temperatures (Tdm), respectively. The activation energy (Ea) and frequency factor (Z) of the degradation reactions were evaluated using Friedman, Broido and Chang methods. Degradation followed first order (n) kinetics. Transmission electron microscopy has revealed the formation of sponge like nano aggregates with population size distribution of around 80–150 nm. 相似文献
87.
Muhammad Younis Tukur Abdulkadir Sulaiman Muhammad Bilal Shafqat Ur Rehman Usman Younas 《理论物理通讯》2020,72(6):65001
This paper studies the new families of exact traveling wave solutions with the modified nonlinear Schrödinger equation, which models the propagation of rogue waves in ocean engineering. The extended Fan sub-equation method with five parameters is used to find exact traveling wave solutions. It has been observed that the equation exhibits a collection of traveling wave solutions for limiting values of parameters. This method is beneficial for solving nonlinear partial differential equations, because it is not only useful for finding the new exact traveling wave solutions, but also gives us the solutions obtained previously by the usage of other techniques (Riccati equation, or first-kind elliptic equation, or the generalized Riccati equation as mapping equation, or auxiliary ordinary differential equation method) in a combined approach. Moreover, by means of the concept of linear stability, we prove that the governing model is stable. 3D figures are plotted for showing the physical behavior of the obtained solutions for the different values of unknown parameters with constraint conditions. 相似文献
88.
89.
Mustafa Avci Bilal Cekic Rabil A. Mashiyev 《Mathematical Methods in the Applied Sciences》2011,34(14):1751-1759
In this paper, by using variational approach and Krasnoselskii's genus theory, we show the existence and multiplicity of the solutions of the p(x)‐Kirchhoff type equation. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
90.
The Lanczos potential for an arbitrary Petrov type II spacetime has been obtained and Robinson–Trautman family of metrics has been considered as an example. 相似文献