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21.
Bilal Ahmad Ghalloo Kashif-ur-Rehman Khan Saeed Ahmad Hanan Y. Aati Jawaher H. Al-Qahtani Barkat Ali Imran Mukhtar Musaddique Hussain Muhammad Nadeem Shahzad Imtiaz Ahmed 《Molecules (Basel, Switzerland)》2022,27(3)
Dracaena reflexa, a traditionally significant medicinal plant, has not been extensively explored before for its phytochemical and biological potential. The present study was conducted to evaluate the bioactive phytochemicals and in vitro biological activities of D. reflexa, and perform in silico molecular docking validation of D. reflexa. The bioactive phytochemicals were assessed by preliminary phytochemical testing, total bioactive contents, and GC-MS analysis. For biological evaluation, the antioxidant (DPPH, ABTS, CUPRAC, and ABTS), antibacterial, thrombolytic, and enzyme inhibition (tyrosinase and cholinesterase enzymes) potential were determined. The highest level of total phenolic contents (92.72 ± 0.79 mg GAE/g extract) was found in the n-butanol fraction while the maximum total flavonoid content (110 ± 0.83 mg QE/g extract) was observed in methanolic extract. The results showed that n-butanol fraction exhibited very significant tyrosinase inhibition activity (73.46 ± 0.80) and acetylcholinesterase inhibition activity (64.06 ± 2.65%) as compared to other fractions and comparable to the standard compounds (kojic acid and galantamine). The methanolic extract was considered to have moderate butyrylcholinesterase inhibition activity (50.97 ± 063) as compared to the standard compound galantamine (53.671 ± 0.97%). The GC-MS analysis of the n-hexane fraction resulted in the tentative identification of 120 bioactive phytochemicals. Furthermore, the major compounds as identified by GC-MS were analyzed using in silico molecular docking studies to determine the binding affinity between the ligands and the enzymes (tyrosinase, acetylcholinesterase, and butyrylcholinesterase enzymes). The results of this study suggest that Dracaena reflexa has unquestionable pharmaceutical importance and it should be further explored for the isolation of secondary metabolites that can be employed for the treatment of different diseases. 相似文献
22.
经过数次技术研究和超常创新战略的大发展,生物催化逐渐达到工业化水平,从而受到人们特别的关注.基于酶值,通过生物途径生产高附加值化合物和精细工业化学品成为人们最感兴趣的领域之一.更广泛的众多生物化学路线可由酶催化来实现,其中还有一些酶尚未被人们发现.另一方面,由于非同源底物和某些化学过程所必需的苛刻条件,导致酶催化过程的效率低、稳定性差,因而限制了生物催化的应用.因此,开发具有多催化特征、更高效率和稳定性的绿色催化剂,成为生物催化的重中之重.计算科学、代谢工程、合成生物,以及机器学习路线的运用为新催化剂的工程化提供了新方法.本文重点介绍了合成生物学和代谢工程在催化中的作用,讨论了用于催化的机器学习算法和如何选择一种预测蛋白质-配体相互作用的算法;为了预测键合和催化功能,综述了分子对接的重要性;最后给出了结束语、未来挑战和前景展望. 相似文献
23.
In this paper, we consider the class of polynomials P(z)= anz^n+ ∑vn=μan-vz^n-v,1≤μ≤n , having all zeros in |z|≤k, k ≤1 and thereby present an alternative proof, independent of Laguerre's theorem, of an inequality concerning the polar derivative of a polynomial. 相似文献
24.
G(3, m, n) is the group presented by
. In this paper, we study the structure of G(3, m, n). We also give a new efficient presentation for the Projective Special Linear group PSL(2, 5) and in particular we prove that PSL(2, 5) is isomorphic to G(3, m, n) under certain conditions. 相似文献
25.
Tanveer Hussain Bokhari Muhammad Bilal Butt Saira Hina Munawar Iqbal Muhammad Daud Muhammad Imran 《Journal of Radioanalytical and Nuclear Chemistry》2017,314(3):1487-1496
The field of therapeutic nuclear medicine is emerging rapidly as choice of treatment in oncology and other cellular malignancies. The growth of this branch of nuclear medicine is greatly facilitated by the introduction of a number of new radiopharmaceuticals and radionuclides. 90Y-radiopharmaceuticals have confirmed their worth in medical and clinical areas in a very short span of time. The 90Y is a radioisotope widely used for therapeutic purposes and considerable perfection has been made to understand the chemistry of 90Y-labeled radiopharmaceuticals. The development of these radiopharmaceuticals can be made favorable by using appropriate buffer, incubation period, optimal pH, specific activity and reaction temperature. In this review, we have discussed the preparation of range of 90Y transporting biological molecules such as antibodies radiolabeled peptides, antigens and microsphere with their clinical applications. 相似文献
26.
We study the coupling of a tetraquark system to an exchanged meson-meson channel, using a pure gluonic theory based four-quark
potential matrix model which is known to fit well a large number of data points for lattice simulations of different geometries of a four-quark
system. We find that if this minimal-area-based potential matrix replaces the earlier used simple Gaussian form for the gluon
field overlap factor f in its off-diagonal terms, the resulting T -matrix and phase shifts develop an angle dependence whose partial-wave analysis reveals D wave and higher angular-momentum components in it. In addition to the obvious implications of this result for the meson-meson
scattering, this new feature indicates the possibility of orbital excitations influencing properties of meson-meson molecules
through a polarization potential. We have used a formalism of the resonating group method, treated kinetic energy and overlap
matrices on model of the potential matrix, but decoupled the resulting complicated integral equations through the Born approximation.
In this exploratory study we have used a quadratic confinement and not included the spin dependence; we also used the approximation
of equal constituent quark masses. 相似文献
27.
Nosheen Akbar Bilal Masud Saba Noor 《The European Physical Journal A - Hadrons and Nuclei》2011,47(10):124
We propose some extensions of the quark potential model to hybrids, fit them to the lattice data and use them for the purpose of calculating the masses, root mean square radii and wave functions at the origin of the conventional and hybrid charmonium mesons. We treat the ground and excited gluonic field between a quark and an antiquark as in the Born-Oppenheimer expansion, and use the shooting method to numerically solve the required Schrödinger equation for the radial wave functions; from these wave functions we calculate the mesonic properties. For masses we also check through a Crank Nichelson discretization. For hybrid charmonium mesons, we consider the exotic quantum number states with J PC = 0+?, 1?+ and 2+?. We also compare our results with the experimentally observed masses and theoretically predicted results of the other models. Our results have implications for scalar form factors, energy shifts, magnetic polarizabilities, decay constants, decay widths and differential cross-sections of conventional and hybrid mesons. 相似文献
28.
Muhammad Bilal Aman-ur- Rehman Shahzad Mahmood Muhammad Ahsan Shahzad Muhammad Sarfraz 《等离子体物理论文集》2023,63(1):e202200102
The dispersion properties and Landau damping rate of ion-acoustic waves (IAWs) with the hybrid Cairns-Tsallis distributed (CTD) electrons and Maxwellian ions are investigated using the plasma kinetic model based on Vlasov-Poisson's equations. For both super-extensive (q < 1) and sub-extensive (q > 1) plasmas, the dielectric response function, real frequency, and Landau damping rate of IAWs are derived. By taking the effect of θi, e (ion-to-electron temperature ratio) into account, it is found that with the increase of ion temperature, the real frequency and wave dispersion effects increase as well (for both super-extensive and sub-extensive cases). Exploring the properties of the Landau damping rate of IAWs with the simultaneous presence of non-thermal parameter α and non-extensive parameter q, a comparison of numerical and analytical results is presented. It is found that in different ranges of θe, i (electron-to-ion temperature ratio), on decreasing the values of the non-extensive parameter and increasing values of the non-thermal parameter, the weak damping rate is observed (vice versa) in super-extensive or super-thermal plasma, although the trend of the damping rate in sub-thermal plasma is similar (as in the case of super-thermal plasma) but is less weak. It is further revealed that the damping rate of IAWs in thermal plasmas (Maxwellian) is stronger than the damping rate of IAWs in the case of non-thermal plasmas (CTD). The current study is applicable to provide deep insight and further allow the exploration of electrostatic plasma modes in different space and laboratory plasma environments where the hybrid CTD plasma exists. 相似文献
29.
Acta Mathematica Sinica, English Series - For a finite group G, the power graph $$\cal{P}(G)$$ is a simple connected graph whose vertex set is the set of elements of G and two distinct vertices x... 相似文献
30.
Designing Excited States: Theory‐Guided Access to Efficient Photosensitizers for Photodynamic Action