Preparation of palladium film by coating photolysis process using KrF or ArF excimer laser

The preparation of palladium (Pd) films has been investigated using KrF or ArF laser irradiation on a Pd acetate (PdAc) coated substrate. A crystalline Pd film could be obtained by KrF laser irradiation (fluence = 15-40 mJ/cm²) but PdAc was found to remain in the film. An increase in the substrate temperature to 423 K decreased the inclusion of the unreacted precursor and produced a better crystallinity. An amorphous and uniform Pd film composed of very fine particles was found to be formed by this process under reduced pressure, which is probably due to the preferential ablation of the crystalline nuclei. ArF laser irradiation is more effective for decomposing the PdAc and for producing a Pd film with a better crystallinity and no (or smaller) organic inclusion.     

Gonyol: Methionine-induced sulfonium accumulation in a dinoflagellate Gonyaulax polyedra

Gonyol, 3S-5-dimethylsulfonio-3-hydroxylpentanoate, was isolated from a dinoflagellate Gonyaulax polyedra cultured in a medium containing methionine and the structure was elucidated by spectroscopic method and confirmed by chemical synthesis. Gonyol was shown to be biogenetically derived from methionine and acetic acid.     

Synthesis and pharmacological evaluation of 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives as specific bradycardic agents

Novel 1,2,3,4-tetrahydroisoquinoline derivatives bearing directly a cyclic amine at the 2-position were prepared and examined for their bradycardic activities in isolated right atria and in anesthetized rats. The structure-activity relationships (SAR) study revealed that the 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline skeleton is essential for the appearance of potent in vitro activity, and that the presence of at least one methoxy group at the 6- or 7-position of the 1,2,3,4-tetrahydroisoquinoline ring is important to exert potent in vitro activity. In vivo tests of selected compounds demonstrated that 2-(1-benzyl-3-piperidyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (6c) exhibited potent bradycardic activity with negligible influence on mean blood pressure in rats, although its potency is a half of that of Zatebradine.     

Synthesis,absolute configuration and conformation of optically active 1,2-homoheptafulvalene

An optically active 1,2-homoheptafulvalene was successfully synthesized and subjected to spectroscopic investigation. The cycloaddition of the optically active hydrocarbon with tetracyanoethylene (TCNE) and 4-phenyl-1,2,4-triazoline-3,5-dione(PTAD) gave a [4 + 2] cycloadduct and a mixture of [8 + 2] cycloadducts, respectively, which are both optically active.     

Asymmetric 1,4-addition of organosiloxanes to alpha,beta-unsaturated carbonyl compounds catalyzed by a chiral rhodium complex

Highly enantioselective 1,4-addition of organosiloxanes to alpha,beta-unsaturated carbonyl compounds was found to be catalyzed by a chiral rhodium complex generated from [Rh(cod)(MeCN)(2)]BF(4) and (S)-BINAP. Both (E)- and (Z)-1-alkenyl groups as well as aryl groups can be introduced enantioselectively into the beta-position of a variety of ketones, esters, and amides. [reaction--see text]     

Development of Fiber Optic Sensing System for Analyzing Isozymes Reaction of Cytochrome P450-1A Doubted as Carcinogen Activator

This paper presents a high performance fiber-optic sensing system for analyzing the isozymes reaction of cytochrome P450 (CYP). In the inherent biological system of lifeguard against chemical toxicants, the enzymes metabolize such chemical species to safer formulae. As is well known, some particular types of CYP, such as CYP-1A, however, often trigger the cancer development process by selective activation of carcinogen. A new technique for medical diagnosis of cancer development at very early or even predictive stage may be achievable based on the evaluation of the activity of the enzymes related to the cancer development by using the present system. In order to demonstrate the potential of the system, CYP-1A induced in liver of living rats by medication using 2,3,7,8-tetrachloro-dibenzofuran (2,3,7,8-TCDF) is measured and curves revealing the fluorescent power transition for each concentration of toxicants are successfully observed with good sensitivity.