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51.
A new fluorescent nucleoside, benzopyridopyrimidine (BPP), which can sharply distinguish between A and G bases opposite BPP has been devised. The base-pairing degeneracy of BPP strongly contributes to the sharp fluorescence change that is dependent on the type of purine bases opposite BPP. The hybridization of an ODN probe containing BPP with a target DNA facilitates the judgment with the naked eye of the type of purine base located at a specific site on the target DNA. The BPP-containing ODN is a very effective probe for A/G SNP typing. 相似文献
52.
M. Tanaka J. Akimitsu Y. Inada N. Kimizuka I. Shindo K. Siratori 《Solid State Communications》1982,44(5):687-690
Anomalies were found in electrical conductivity and specific heat at the two-step transition in the stoichiometric YFe2O4. It is concluded that the transition is a new type of Verwey transition: i.e., ordering of ionic charge, Fe2+ and Fe3+, accompanied by lattice distortion and antiferromagnetic spin ordering. 相似文献
53.
Teshima K Kondo T Maeda C Oda T Hagimoto T Tsukuda R Yoshimura Y 《Journal of mass spectrometry : JMS》2002,37(6):631-638
We investigated the application of alkylamines, as additives to the mobile phase, to a quantification method for the metabolites, M-III and M-IV, of TAK-778, which is a new bone anabolic agent, in human serum using liquid chromatography/tandem mass spectrometry (LC/MS/MS). Prior to setting up the analytical method, we found that 1-alkylamines co-existing with M-III and M-IV in the turbo ionsprayed solution formed 1-alkylammonium adduct molecules of these metabolites during the ionization process, and the abundance of the adduct ions was considerably higher than that of protonated molecules ([M + H](+)s) of these metabolites. Based on these findings, we investigated a variety of 1-alkylamines and their spiked concentrations in the mobile phase for LC/MS/MS analysis to obtain higher sensitivities for the quantification of these metabolites. After these examinations, we found that 1-hexylamine at a final concentration of 0.05 mmol l(-1) was the most suitable additive for the mobile phase, and set the selected reaction monitoring (SRM) ions for the 1-hexylammonium adduct molecule and [M + H](+), allowing about a fivefold gain in the SRM chromatographic peak compared with that without 1-hexylamine. The adduct ion was considered to be formed by interaction between the amino group of 1-hexylamine and the phosphoryl group of M-III and M-IV. The internal standard (I.S.) used was deuterated M-III for each metabolite. The analytes and I.S. were extracted with diethyl ether from serum samples at neutral pH and injected into the LC/MS/MS system with a turbo ionspray interface. The limit of quantification for both analytes was 0.5 ng ml(-1) when 0.1 ml of serum was used, and the calibration curves were linear in the range 0.5-100 ng ml(-1). The method was precise; the intra- and inter-day precisions of the method were not more than 5.6%. The accuracy of the method was good, with deviations between added and calculated concentrations of M-III and M-IV being typically within 16.6%. This method provided reliable pharmacokinetic data for M-III and M-IV after the intramuscular administration of TAK-778 sustained-release formulation in humans. 相似文献
54.
Hiroshi Tsukuda Masaru Masuzaki Norio Toyosugi Cha Yeol Lee Ritoku Ando Keiichi Kamada Tsuguhiro Watanabe 《International Journal of Infrared and Millimeter Waves》2001,22(8):1147-1162
A linear analysis is described on stabilities driven by an intense relativistic electron beam in an infinitely long, plasma-filled, and dielectric-lined circular waveguide immersed in a finite strength axial magnetic field. A dispersion equation is derived from the cold fluid theory and solved numerically. Beam-plasma instabilities due to interaction between beam modes and the Trivelpiece-Gould modes appear as well as the Cherenkov and the cyclotron Cherenkov instabilities. Parametric researches are carried out varying magnetic field strength, plasma density, and dielectric constant. Effects of a finite magnetic field and plasma filling are discussed in connection with the possibilities of using this system as a microwave radiation source. 相似文献
55.
56.
Anisotropic swelling of hydrogel nanowires based on poly(vinylpyrrolidone) fabricated by single‐particle nanofabrication technique
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Satoshi Tsukuda Masaaki Omichi Masaki Sugimoto Akira Idesaki Vikas S. Padalkar Shu Seki 《Journal of Polymer Science.Polymer Physics》2016,54(19):1950-1956
We report a hydrogel nanowire based on poly(vinylpyrrolidone) (PVP) and N,N'‐methylenebis(acrylamide) (MBA), which have anisotropic swelling ratio for radius and length direction. The PVP/MBA nanowires were fabricated by single particle nanofabrication technique, which is a technique for the fabrication of polymeric nanowires using the single ion event, that cause the crosslinking reaction of polymer chains within the ion tracks along the ion paths; furthermore the size (length and radius) of the nanowires was controlled by changing the film thickness and amount of MBA crosslinker. The swelling behaviors in air and water were observed using atomic force microscopy. The PVP/MBA nanowires exhibited anisotropic swelling along the length and radius in aqueous environments, because the hydrogel nanowires consisted of crosslinked networks with inhomogeneous crosslinking points, which reflected the initial energy distribution from incident an ion within the ion track. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016 , 54, 1950–1956 相似文献
57.
Akimitsu Ishihara Satoshi Tominaka Shigenori Mitsushima Hideto Imai Osamu Sugino Ken-ichiro Ota 《Current Opinion in Electrochemistry》2020
To obtain an ideal electrocatalysts for hydrogen fuel cells, we investigated group 4 and 5 oxide-based compounds because of their high degree of freedom. First-principles calculations revealed that oxide surfaces such as those of titanium oxide could break down the universal scaling to achieve the ideal state of the oxygen reduction reaction. We experimentally clarified that the active sites were oxygen vacancies for tantalum and zirconium oxides, in addition to doped foreign elements and crystalline structures for titanium oxide. We successfully demonstrated that precious metal-free and carbon-free oxide-based cathodes have high quality active sites and superior durability in 0.1 M sulfuric acid at 80°C. Our strategy was developed as follows: (1) Active sites are created on the oxide surface by modifying the crystalline structure and electronic states and (2) electrons participating in the oxygen reduction reaction are supplied by nanosized oxide particles and oxide films through the tunneling effect of electrons. 相似文献
58.
The optical properties of spherical and polyhedral carbon onions were studied in relation to the strong hump centered at 217.5
nm (4.6 μm−1) in the interstellar-dust extinction curve. The ultraviolet-visible absorption spectra of onions prepared by thermal annealing
of diamond nanoparticles were measured. Theoretical calculations for the spherical and polyhedral carbon onions were also
carried out to explain the experimental spectra.
From Fizika Tverdogo Tela, Vol. 44, No. 3, 2002, pp. 433–436.
Original English Text Copyright ? 2002 by Tomita, Hayashi, Tsukuda, Fujii.
This article was submitted by the authors in English. 相似文献
59.
Dr. Jingyun Tan Dr. Xiushang Xu Jun Liu Dr. Serhii Vasylevskyi Dr. Zesen Lin Prof. Ryota Kabe Prof. Yingping Zou Prof. Klaus Müllen Prof. Akimitsu Narita Prof. Yunbin Hu 《Angewandte Chemie (International ed. in English)》2023,62(18):e202218494
Double helicenes are appealing chiral frameworks. Their π-extension is desirable to achieve (chir)optical response in the visible and near-infrared (NIR) region, but access to higher double [n]helicenes (n≥8) has remained challenging. Herein, we report an unprecedented π-extended double [9]helicene ( D9H ), unambiguously revealing its structure by single-crystal X-ray diffraction. D9H shows remarkable NIR emission from 750 to 1100 nm with a high photoluminescence quantum yield of 18 %. In addition, optically pure D9H exhibits panchromatic circular dichroism with a notable dissymmetry factor (gCD) of 0.019 at 590 nm, which is among the highest in the visible region for reported helicenes. 相似文献
60.
Dr. Kunihiko Morihiro Yasuhiro Tomida Daisuke Fukui Manami Hasegawa Prof. Akimitsu Okamoto 《Angewandte Chemie (International ed. in English)》2023,62(44):e202306587
Many microRNAs (miRNAs) are characteristically found in cancer cells, making miRNAs promising marker biomolecules for cancer diagnosis and therapeutics. However, it is challenging to use miRNA as a cancer signature because it is difficult to convert the nucleic acid sequence information into molecular functionality. To address this challenge, we realize nucleic acid-to-small molecule converters using hairpin DNA circuits. Harnessing a Staudinger reduction as a trigger for the conversion, we constructed hybridization chain reaction (HCR) and catalytic hairpin assembly (CHA) circuits that respond to oncogenic miR-21. Fluorophore and dye molecules were released in response to miR-21 through the HCR, providing fluorogenic and chromogenic readouts. Selective cytotoxicity in miR-21-abundant cells was realized by the CHA to release the anticancer drug SN-38. This would be the first example of selective activation of a small-molecule prodrug triggered by oncogenic miRNA in human living cells. 相似文献