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951.
Dr. Masafumi Minoshima Taro Umeno Kohei Kadooka Margaux Roux Namiko Yamada Prof. Dr. Kazuya Kikuchi 《Angewandte Chemie (International ed. in English)》2023,62(18):e202301704
To understand the function of protein in live cells, real-time monitoring of protein dynamics and sensing of their surrounding environment are important methods. Fluorescent labeling tools are thus needed that possess fast labeling kinetics, high efficiency, and long-term stability. We developed a versatile chemical protein-labeling tool based on fluorophore-conjugated diazabicyclooctane β-lactamase inhibitors (BLIs) and wild-type TEM-1 β-lactamase protein tag. The fluorescent probes efficiently formed a stable carbamoylated complex with β-lactamase, and the labeled proteins were visualized over a long period of time in live cells. Moreover, use of an α-fluorinated carboxylate ester-based BLI prodrug enabled the probe to permeate cell membranes and stably label intracellular proteins after unexpected spontaneous ester hydrolysis. Lastly, combining the labeling tool with a pH-activatable fluorescent probe allowed visual monitoring of lysosomal protein translocation during autophagy. 相似文献
952.
Kang Xia Prof. Dr. Kazuya Yamaguchi Prof. Dr. Kosuke Suzuki 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2023,135(1):e202214506
Polyoxometalates (POMs), anionic metal-oxygen nanoclusters that possess various composition-dependent properties, are widely used to modify the existing properties of metal nanoparticles and to endow them with new ones. Herein, we present an overview of recent advances in hybrid materials that consist of metal nanoparticles and POMs. Following a brief introduction on the inception of this area and its development, representative properties and applications of these materials in various fields such as electrochemistry, photochemistry, and catalysis are introduced. We discuss how the combination of two classic inorganic materials facilitates cooperative and synergistic behavior, and we also give personal perspectives on the future development of this field. 相似文献
953.
William J. Bailey Paul Y. Chen Shuh-Cheng Chen Wen-Bin Chiao Takeshi Endo Benjamin Gapud Vijaya Kuruganti Yin-Nian Lin Zhende Ni Cai-Yuan Pan Scott E. Shaffer Luann Sidney Shang-Ren Wu Noboru Yamamoto Noboro Yamazaki Kazuya Yonezawa Lin-Lin Zhou 《Macromolecular Symposia》1986,6(1):81-100
Since a carbon-oxygen double bond is considerably more stable than a carbon-carbon double bond, it has been possible to use this driving force to promote free radical ring-opening polymerization of unsaturated heterocyclic compounds. This process, for the first time, has permitted the introduction of functional groups, such as esters, amides and carbonates, into the backbone of addition polymers. Hydrolysis of the copolymers with common monomers produced oligomers capped with hydroxyl, amino or carboxylic acid groups. The presence of an ester group in a copolymer, such as in a copolymer of ethylene, render the copolymer biodegradable. 相似文献
954.
Dr. Yoshiyuki Manabe Yuki Iizuka Ryuku Yamamoto Keita Ito Kanae Hatano Dr. Kazuya Kabayama Prof. Koichi Fukase 《Angewandte Chemie (International ed. in English)》2023,62(30):e202304779
Antibody dynamics on membranes, such as endocytosis and clustering, are vital in determining antibody functions. In this study, we demonstrated that glycan conjugation can modulate antibody dynamics through the glycan–lectin interaction to regulate its potency. The anti-HER2 antibody, an anti-breast-cancer antibody, was conjugated with galactose-containing N-glycan, and its internalization was suppressed by interaction with galectin-3, leading to enhanced complement-dependent cytotoxic (CDC) activity. This glycan–antibody conjugate is proposed as a new approach to modulate antibody activity and may provide an alternative strategy for redeveloping antibody drugs that do not exhibit sufficient activity. 相似文献
955.
Kazuya Haraguchi Shinobu Sato Manabu Habu Naomi Yada Mana Hayakawa Masaaki Sasaguri Izumi Yoshioka Kazuhiro Tominaga Shigeori Takenaka 《Electroanalysis》2023,35(8):e202200564
In order to improve the survival rate of oral squamous cell carcinoma (OSCC) patients, a reliable diagnostic method for early OSCC detection is required that is minimally invasive, less burdensome to the patient, and has high sensitivity and specificity. Therefore, we performed the detection of abnormal methylation at three locations in the hTERT promoter region of oral exfoliated cells by employing the ferrocenylnaphthalene diimide (FND)-based electrochemical hybridization assay (FND-EHA) using three types of DNA probe-immobilized electrodes. We also performed liquid cytology using oral exfoliated cells and compared these obtained data to evaluate whether FND- EHA can be used as an OSCC screening system. The results showed a good correlation between this method and conventional OSCC screening, and cytology. In addition, FND-EHA was also able to determine samples that had been ambiguously determined by liquid cytology. This indicates that FND-EHA may be useful as an OSCC screening system. 相似文献