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11.
Qi ZM Matsuda N Santos J Yoshida T Takatsu A Kato K 《Journal of colloid and interface science》2004,271(1):249-253
Broadband, time-resolved optical waveguide (OWG) spectroscopy has been used for in situ, real-time investigation into the self-assembly of metal nanoparticle monolayers. The OWG spectroscopy makes it possible to use the transverse electric (TE) and transverse magnetic (TM) modes to measure surface plasmon absorption of immobilized metal nanoparticles in two directions, parallel and normal to the waveguide surface. Therefore, this technique can provide direction-dependent information on the metal nanoparticles at the interface. In this paper, a 50-microm-thick glass plate was used as a slab waveguide and the kinetics of Au nanoparticle adsorption on a hemoglobin-functionalized glass substrate was examined in the early stage of self-assembly. The findings show that with the TE mode the surface plasmon resonance (SPR) behavior for immobilized Au nanoparticles is different from that with the TM mode. 相似文献
12.
Akiko Saito Mana Emoto Akira Tanaka Yuki Doi Kazuaki Shoji Yoshiyuki Mizushina Hiroshi Ikawa Hiromi Yoshida Nobuyasu Matsuura Noriyuki Nakajima 《Tetrahedron》2004,60(52):12043-12049
A simple method for the synthesis of procyanidin B3 substituted with a galloyl group at the 3 and 3″ position is described. Condensation of a benzylated catechin-3-O-gallate electrophile with a nucleophile, catechin and catechin-3-O-gallate, proceeded smoothly and stereoselectively to afford the corresponding dimer gallates, procyanidin B3-3-O-gallate and procyanidin B3-3,3″-di-O-gallate, in good yields. Further, their antioxidant activities on UV-induced lipid peroxide formation, DPPH radical scavenging activity and inhibitory activity of DNA polymerase were also investigated. Among three procyanidin B3 congeners (procyanidin B3, 3-O-gallate and 3,3″-di-O-gallate), the 3,3″-di-O-gallate derivative showed the strongest antioxidant and radical scavenging activity. Interestingly, the 3-O-gallate derivative was the strongest inhibitor of mammalian DNA polymerase with IC50 value of 0.26 μM, although it showed the weakest antioxidant and radical scavenging activity. It became apparent that the presence of a galloyl group at the C-3 position in the proanthocyanidin oligomer was very important for biological activity, however, the antioxidant activity of these compounds was not parallel to the DNA polymerase inhibitory activity. 相似文献
13.
Ikuta A Mizuta N Kitahata S Murata T Usui T Koizumi K Tanimoto T 《Chemical & pharmaceutical bulletin》2004,52(1):51-56
Six novel branched beta-cyclodextrins (betaCDs) having beta-D-galactose residues on the non-reducing terminal of the sugar side chains, namely 6(1),6(4)-di-O-(beta-D-galactosyl)-betaCD (10), 6-O-(beta-D-galactosyl)-betaCD (11), 6(1),6(4)-di-O-(beta-lactosyl)-betaCD (14), 6-O-(beta-lactosyl)-betaCD (15), 6(1),6(4)-di-O-(4'-O-beta-D-galactosyl-beta-lactosyl)-betaCD (18), and 6-O-(4'-O-beta-D-galactosyl-beta-lactosyl)-betaCD (19), were chemically synthesized using the trichloroacetimidate method. The reaction products were separated by HPLC on an amino column into dibranched and monobranched betaCDs. Their structures were confirmed by mass spectrometry (MS) and two-dimensional (2D) NMR spectroscopic analysis. To study the length of the sugar side chains attached to the CD ring, which leads to differences in the functions of the branched CDs, interactions of these compounds with peanut (Arachis hypogaea) agglutinin (PNA) were investigated using an optical biosensor and an inhibition assay based on hemagglutination. The results showed that all branched betaCDs interacted with PNA, and the binding affinity was 18>14>10 and 19>15>11 when the derivatives were compared on the basis of side chain length. 相似文献
14.
Akiko Tsuhako Jing-Qian He Mariko Mihara Naoko Saino Sentaro Okamoto 《Tetrahedron letters》2007,48(52):9120-9123
Ketones and aldehydes were effectively reduced to the corresponding alcohols (or their silyl ethers) by the reaction with CaH2 and R3SiCl in the presence of a catalytic amount of ZnCl2. In the absence of the carbonyl substrate, the reagent reduced R3SiCl to the corresponding hydrosilane under mild reaction conditions. 相似文献
15.
Satoshi ObikaJyun-ichi Andoh Mayumi OnodaOsamu Nakagawa Akiko HirotoTomomi Sugimoto Takeshi Imanishi 《Tetrahedron letters》2003,44(28):5267-5270
A novel bridged nucleic acid monomer, 3′-amino-3′-deoxy-5-methyl-3′-N,4′-C-methyleneuridine, was successfully synthesized via a useful and convenient azetidine ring formation under Staudinger's conditions. A 1H NMR experiment and a PM3 calculation revealed that the sugar moiety of the novel bridged nucleic acid monomer, 3′-amino-3′,4′-BNA, was restricted to S-type conformation. 相似文献
16.
Masahiko Takahashi Tomoko Gunji Akiko Ichikawa 《Journal of heterocyclic chemistry》2002,39(5):1029-1033
Reactions of 1,2‐dihydro‐4H‐3,1‐benzothiazine‐2,4‐dithiones (trithioisatoic anhydrides) 3 with N‐substi‐tuted benzylamines 9 gave 1,2‐dihydroquinazoline‐4‐thiones 10 , o‐thioureidodithiobenzoic acid 11 , o‐aminothiobenzamides 12 , 2‐amino‐3,1‐benzothiazine‐4‐thiones 13 , or quinazoline‐2,4‐dithiones 14 , depending on the kinds of amine and the reaction solvent. On the other hand, reaction of 3 with trialkyl phosphites afforded dialkyl (1,2‐dihydro‐2‐thioxo‐4H‐3,1‐benzothiazin‐4‐yl)phosphonates 18 . 相似文献
17.
18.
Uehara K Hikichi S Inagaki A Akita M 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(9):2788-2809
A series of dinuclear complexes, [Tp(R)M--M'L(n)] [Tp(iPr(2) )M--Co(CO)(4) (1; M=Ni, Co, Fe, Mn); Tp(#)M--Co(CO)(4) (1'; M=Ni, Co); Tp(#)Ni--RuCp(CO)(2) (3')] (Tp(iPr(2) )=hydrotris(3,5-diisopropylpyrazolyl)borato; Tp(#) (Tp(Me(2),4-Br))=hydrotris(3,5-dimethyl-4-bromopyrazolyl)borato), has been prepared by treatment of the cationic complexes [Tp(iPr(2) )M(NCMe)(3)]PF(6) or the halo complexes [Tp(#)M--X] with the appropriate metalates. Spectroscopic and crystallographic characterization of 1-3' reveals that the tetrahedral, high-spin Tp(R)M fragment and the coordinatively saturated carbonyl-metal fragment (M'L(n)) are connected only by a metal-metal interaction and, thus, the dinuclear complexes belong to a unique class of xenophilic complexes. The metal-metal interaction in the xenophilic complexes is polarized, as revealed by their nu(CO) vibrations and structural features, which fall between those of reference complexes: covalently bonded species [R--M'L(n)] and ionic species [M'L(n)](-). Unrestricted DFT calculations for the model complexes [Tp(H(2) )Ni--Co(CO)(4)], [Tp(H(2) )Ni--Co(CO)(3)(PH(3))], and [Tp(H(2) )Ni--RuCp(CO)(2)] prove that the two metal centers are held together not by covalent interactions, but by electrostatic attractions. In other words, the obtained xenophilic complexes can be regarded as carbonylmetalates, in which the cationic counterpart interacts with the metal center rather than the oxygen atom of the carbonyl ligand. The xenophilic complexes show divergent reactivity dependent on the properties of donor molecules. Hard (N and O donors) and soft donors (P and C donors) attack the Tp(R)M part and the ML(n) moiety, respectively. The selectivity has been interpreted in terms of the hard-soft theory, and the reactions of the high-spin species 1-3' with singlet donor molecules should involve a spin-crossover process. 相似文献
19.
In recent years scanning near-field optical microscopy (SNOM) has developed into a powerful surface analytical technique for observing specimens with lateral resolution equal to or even better than 100 nm. A large number of applications, from material science to biology, have been reported. In this paper, two different kinds of near-field optical microscopy, aperture and scattering-type SNOM, are reviewed together with recent studies in surface analysis and biology. Here, near-field optical techniques are discussed in comparison with related methods, such as scanning probe and standard optical microscopy, with respect to their specific advantages and fields of application. 相似文献
20.
Contribution of individual zinc ligands to metal binding and peptide folding of zinc finger peptides
Little is known about the contribution of individual zinc-ligating amino acid residues for coupling between zinc binding and protein folding in zinc finger domains. To understand such roles of each zinc ligand, four zinc finger mutant peptides corresponding to the second zinc finger domain of Sp1 were synthesized. In the mutant peptides, glycine was substituted for one of four zinc ligands. Their metal binding and folding properties were spectroscopically characterized and compared to those of the native zinc finger peptide. In particular, the electronic charge-transfer and d-d bands of the Co(II)-substituted peptide complexes were used to examine the metal coordination number and geometry. Fluorescence emission studies revealed that the mutant peptides are capable of binding zinc despite removing one ligand. Circular dichroism results clearly showed the induction of an alpha-helix by zinc binding. In addition, the structures of certain mutant zinc finger peptides were simulated by molecular dynamics calculation. The information indicates that His23 and the hydrophobic core formed between the alpha-helix and the beta-sheet play an essential role in alpha-helix induction. This report demonstrates that each ligand does not contribute equally to alpha-helix formation and coordination geometry in the zinc finger peptide. 相似文献