Effective photoexcitation in gold nanowells based on localized surface plasmon

The localization of the surface plasmon (SP) field in nanospace using wavelength-sized gold wells prepared on a glass substrate and its application to excite fluorophores immobilized on the bottom surfaces have been studied.     

High throughput screening of O-glycosylation conditions

We report a novel methodology for rapid and quantitative screening of O-glycosylation reactions of application to the analysis of parallel reaction systems. Our system exploits perdeuterated benzyl (Bn-d₇) ether, and stereoselectivity and yield are evaluated by ¹H NMR and MALDI-TOF MS, respectively. This paper summarizes over 240 screenings of 1 → 3 linkage formation between glucose residues targeting the α-isomer in high yield.     

Statevector reduction in discrete time: A random walk in Hilbert space

A simple model is presented in which the statevector evolves every seconds in one of two ways, according to a particular probability rule. It is shown that this random walk in Hilbert space results in reduction of the statevector. It is also shown how the continuous spontaneous localization (CSL) theory of statevector reduction is achieved as a limiting case of this model, exactly as Brownian motion is a limiting case of ordinary random walk. Finally, a slightly different but completely equivalent form of the CSL equations suggested by the simple model given here is discussed.     

Geometric indices and the Alexander polynomial of a knot

It is well-known that any Laurent polynomial satisfying and is the Alexander polynomial of a knot in . We show that can be realized by a knot which has the following properties simultaneously: (i) tunnel number 1; (ii) bridge index 3; and (iii) unknotting number 1.

     

Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies

Several beta-secretase inhibitors were designed based on hydroxyethylamine dipeptide isostere (HDI) structures and were synthesized by a methodology using the aza-Payne rearragement and O,N-acyl transfer reactions to study their structure-activity relationships. Among these pseudopeptides, effective compounds were developed as the first beta-secretase inhibitors containing the HDI transition state mimic with potent enzyme inhibitory activity (IC50 < 100 nM).     

Concise synthesis of pyrrolophenanthridine alkaloids using a Pd-mediated biaryl coupling reaction with regioselective C-H activation via the intramolecular coordination of the amine to Pd

The concise synthesis of Amaryllidaceae alkaloids, such as anhydrolycorinone, anhydrolycorin-7-one, assoanine, and oxoassoanine, which have a pyrrolophenanthridine skeleton, was achieved in moderate yield using the Pd-mediated biaryl coupling reaction of 1-(2-halobenzyl)-2,3-dihydroindole, which applied the regioselective C-H activation method with intramolecular coordination of the benzylamino group to Pd.