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排序方式: 共有114条查询结果,搜索用时 31 毫秒
71.
Alumina supported colloidal Ru nanoparticles, with an initial average size of 4.8 nm, show high activity for NO conversion for T > or = 450 degrees C and remarkably high selectivity (approximately 80%) to syngas at 600 degrees C. 相似文献
72.
Tsuchida Kazuki Maruyama Akane Kobayashi Yuma Sato Gen Atsumi Ryosuke Murakami Yoshinori 《Research on Chemical Intermediates》2022,48(3):1045-1061
Research on Chemical Intermediates - Although research on microbubbles (MBs) has intrigued a lot of researchers, very few studies have been done about the influences of MBs on the free radical... 相似文献
73.
The lithium anionic species generated from O-alkanoylTEMPOs upon treatment with LDA were first employed as a nucleophile for alkylation, Michael addition, direct aldol reaction, and others. The alkylation occurred smoothly at the methylene carbon, and no alkylation was found in the isobutyryl analogue, while silylation was scarcely attainable. Substitutions of the heteroatom were achieved by reaction with PhSSPh and DEAD. The reactivity of these anionic species is successfully extended to aldol reactions in which moderate anti or syn selectivity was executed with propionyl derivatives. Tandem Michael addition of lithium amide followed by aldol reaction was performed on the O-crotonoylTEMPOs. 相似文献
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Akane Fujii Dr. Osamu Nakagawa Yuki Kishimoto Takumi Okuda Yusuke Nakatsuji Natsumi Nozaki Dr. Yuuya Kasahara Prof. Dr. Satoshi Obika 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(31):7443-7448
Metal-mediated base pairs (MMBPs) formed by natural or artificial nucleobases have recently been developed. The metal ions can be aligned linearly in a duplex by MMBP formation. The development of a three- or more-metal-coordinated MMBPs has the potential to improve the conductivity and enable the design of metal ion architectures in a duplex. This study aimed to develop artificial self-bases coordinated by three linearly aligned AgI ions within an MMBP. Thus, artificial nucleic acids with a 1,3,9-triaza-2-oxophenoxazine (9-TAP) nucleobase were designed and synthesized. In a DNA/DNA duplex, self-base pairs of 9-TAP could form highly stable MMBPs with three AgI ions. Nine equivalents of AgI led to the formation of three consecutive 9-TAP self-base pairs with extremely high stability. The complex structures of 9-TAP MMBPs were determined by using electrospray ionization mass spectrometry and UV titration experiments. Highly stable self-9-TAP MMBPs with three AgI ions are expected to be applicable to new DNA nanotechnologies. 相似文献
76.
Nandiyanto AB Akane Y Ogi T Okuyama K 《Langmuir : the ACS journal of surfaces and colloids》2012,28(23):8616-8624
Mesopore-free hollow silica particles with a spherical shape, smooth surface, and controllable diameter (from 80 to 300 nm) and shell thickness (from 2 to 25 nm) were successfully prepared using an additive-free synthesis method. Different from other hollow particle developments, a mesopore-free shell was produced because of the absence of additive. Although common reports pointed out the importance of the additional additive in pasting and growing silica on the surface of a template, here we preferred to exploit the effect of the template charge in gaining the silica coating process. To form the silica, basic amino acid (i.e., lysine) was used as a catalyst to replace ammonia or hydrazine, which is harmless and able to control the silica growth and produce hollow particles with smooth surfaces. Control of the particle diameter was drastically achieved by altering the size of the template. The flexibility of the process in controlling the shell thickness was predominantly attained by varying the compositions of the reactants (i.e., silica source and catalyst). The present mesopore-free hollow particles could be efficiently used for various applications, especially for thermal insulator and optical devices because of their tendency not to adsorb large molecules, as confirmed by adsorption analysis. 相似文献
77.
Westwood IM Kawamura A Russell AJ Sandy J Davies SG Sim E 《Combinatorial chemistry & high throughput screening》2011,14(2):117-124
Arylamine N-acetyltransferases (NATs) are a family of enzymes found in eukaryotes and prokaryotes. While the precise endogenous function of NAT remains unknown for most organisms, recent evidence has shown that the expression of human NAT1 is up-regulated in estrogen receptor positive breast cancer. Additionally, NAT in mycobacteria is required for mycobacterial cell wall biosynthesis and survival of the organisms within macrophage. It is therefore important to develop small molecule inhibitors of NATs as molecular tools to study the function of NATs in various organisms. Such inhibitors may also prove useful in future drug design, for example in the development of anti tubercular agents. We describe a high-throughput screen of a proprietary library of 5016 drug-like compounds against three prokaryotic NAT enzymes and two eukaryotic NAT enzymes. 相似文献
78.
Rotili D Altun M Kawamura A Wolf A Fischer R Leung IK Mackeen MM Tian YM Ratcliffe PJ Mai A Kessler BM Schofield CJ 《Chemistry & biology》2011,18(5):642-654
2-oxoglutarate (2-OG)-dependent oxygenases have diverse roles in human biology. The inhibition of several 2-OG oxygenases is being targeted for therapeutic intervention, including for cancer, anemia, and ischemic diseases. We report a small-molecule probe for 2-OG oxygenases that employs a hydroxyquinoline template coupled to a photoactivable crosslinking group and an affinity-purification tag. Following studies with recombinant proteins, the probe was shown to crosslink to 2-OG oxygenases in human crude cell extracts, including to proteins at endogenous levels. This approach is useful for inhibitor profiling, as demonstrated by crosslinking to the histone demethylase FBXL11 (KDM2A) in HEK293T nuclear extracts. The results also suggest that small-molecule probes may be suitable for substrate identification studies. 相似文献
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