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61.
Ajit K. Parhi 《Tetrahedron》2008,64(42):9821-9827
In this report the concept of converting carbohydrate to non-carbohydrate asymmetric molecules has been successfully exploited. The mixed acetal segment of glyceroplasmalopsychosine, a novel glycolipid, has been synthesized in a stereospecific manner using two simple sugar units. The glycosidation reaction between these two monosaccharides ensured the correct acetal stereocenter of the target molecule. Either olefin metathesis or heterogeneous Wittig reactions were used for constructing the long aliphatic chain of glyceroplasmalopsychosine. 相似文献
62.
Mohamed E Abdul-Rahman PS Doustjalali SR Chen Y Lim BK Omar SZ Bustam AZ Singh VA Mohd-Taib NA Yip CH Hashim OH 《Electrophoresis》2008,29(12):2645-2650
A 35 kDa glycoprotein whose abundance was previously demonstrated to be enhanced in sera of patients with endometrial adenocarcinoma (n = 12), was isolated from pooled sera of three of the cancer patients using champedak galactose-binding lectin affinity chromatography in the present study. Subjecting it to 2-DE and MS/MS, the glycoprotein was identified as the O-glycosylated fragment of inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4). When compared to control sera (n = 17), expression of the 35 kDa ITIH4 cleavage fragment was demonstrated to be significantly enhanced in sera of patients with breast carcinoma (n = 10), epithelial ovarian carcinoma (n = 10), and germ cell ovarian carcinoma (n = 10) but not in patients with nasopharyngeal carcinoma (n = 13) and osteosarcoma (n = 7). The lectin-based electrophoretic bioanalytical method adopted in the present study may be used to assess the physiological relevance of ITIH4 fragmentation and its correlation with different malignancies, their stages and progression. 相似文献
63.
P. K. Roychowdhuary Sangeeta Mehrotra Sugandh Srivastava K. K. Upadhay Rakesh K. Mishra Ajit Kumar Shalini Upadhyay 《Journal of heterocyclic chemistry》2008,45(3):741-744
64.
Ajit K. Parhi 《Tetrahedron letters》2008,49(21):3395-3399
Three fluorescent probes were synthesized aiming for optical imaging to detect amyloid plaques present in the patients with Alzheimer’s disease (AD). These compounds were prepared via Sonogashira coupling of a well-defined fluorophore (4-bora-3a,4a-diaza-s-indacene, BODIPY) with the pharmacophore possessing either a stilbene or a diphenylacetylene moiety. Different polyethylene glycol chain lengths were used as linkers between the fluorophore and the pharmacophore to adjust the lipophilicity of these probes. These compounds exhibit strong fluorescence emission between 665 and 680 nm and have very high extinction coefficients comparable to the parent fluorophore, BODIPY dye. 相似文献
65.
John Gallien Bhairavi Srinageshwar Kellie Gallo Gretchen Holtgrefe Sindhuja Koneru Paulina Sequeiros Otero Catalina Alvarez Bueno Jamie Mosher Alison Roh D. Stave Kohtz Douglas Swanson Ajit Sharma Gary Dunbar Julien Rossignol 《Molecules (Basel, Switzerland)》2021,26(19)
Glioblastoma (GB) is a deadly and aggressive cancer of the CNS. Even with extensive resection and chemoradiotherapy, patient survival is still only 15 months. To maintain growth and proliferation, cancer cells require a high oxidative state. Curcumin, a well-known anti-inflammatory antioxidant, is a potential candidate for treatment of GB. To facilitate efficient delivery of therapeutic doses of curcumin into cells, we encapsulated the drug in surface-modified polyamidoamine (PAMAM) dendrimers. We studied the in vitro effectiveness of a traditional PAMAM dendrimer (100% amine surface, G4 NH2), surface-modified dendrimer (10% amine and 90% hydroxyl-G4 90/10-Cys), and curcumin (Cur)-encapsulated dendrimer (G4 90/10-Cys-Cur) on three species of glioblastoma cell lines: mouse-GL261, rat-F98, and human-U87. Using an MTT assay for cell viability, we found that G4 90/10-Cys-Cur reduced viability of all three glioblastoma cell lines compared to non-cancerous control cells. Under similar conditions, unencapsulated curcumin was not effective, while the non-modified dendrimer (G4 NH2) caused significant death of both cancerous and normal cells. By harnessing and optimizing the components of PAMAM dendrimers, we are providing a promising new route for delivering cancer therapeutics. Our results with curcumin suggest that antioxidants are good candidates for treating glioblastoma. 相似文献
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Tridib Kumar Bhowmick Akkihebbal K. Suresh Shantaram G. Kane Ajit C. Joshi Jayesh R. Bellare 《Journal of nanoparticle research》2009,11(3):655-664
Herbs and minerals are the integral parts of traditional systems of medicine in many countries. Herbo-Mineral medicinal preparations
called Bhasma are unique to the Ayurvedic and Siddha systems of Indian Traditional Medicine. These preparations have been used since long and are claimed to be the very effective
and potent dosage form. However, there is dearth of scientific analytical studies carried out on these products, and even
the existing ones suffer from incomplete analysis. Jasada Bhasma is a unique preparation of zinc belonging to this class. This particular preparation has been successfully used by traditional
practitioners for the treatment of diabetes and age-related eye diseases. This work presents a first comprehensive physicochemical
characterization of Jasada Bhasma using modern state-of-the-art techniques such as X-ray photoelectron spectroscopy (XPS), inductively coupled plasma (ICP),
elemental analysis with energy dispersive X-ray analysis (EDAX), dynamic light scattering (DLS), and transmission electron
microscopy (TEM). Our analysis shows that the Jasada Bhasma particles are in oxygen deficient state and a clearly identifiable fraction of particles are in the nanometer size range.
These properties like oxygen deficiency and nanosize particles in Jasada Bhasma might impart the therapeutic property of this particular type of medicine.
A. C. Joshi: Private Practitioner (Vaidya). 相似文献