Shallow Water Flow Analysis with Moving Boundary Technique Using Least-squares Bubble Function

This paper presents a computational simulation method for a river problem. For the actual flow problem, it is necessary to compute flow velocity, water elevation and water region at the same time. For the basic formulation, the unsteady shallow water equations are used. As the numerical approach, implicit FEM is proposed by bubble function. To control numerical stability and accuracy, LSBF (Least-Squares Bubble Function) is used to solve the finite element equations. Also, the fixed boundary technique is combined to deal with wet and dry areas in the moving finite element mesh. Some numerical tests are shown to check this method.     

Constant heat flux solution for mixed convection boundary layer viscoelastic fluid

The mixed convection boundary layer of a viscoelastic fluid past a circular cylinder with constant heat flux is discussed. The boundary layer equations are an order higher than those for the Newtonian (viscous) fluid and the adherence boundary conditions are insufficient to determine the solution of these equations completely. The governing non-similar partial differential equations are transformed into dimensionless forms and then solved numerically using the Keller-box method by augmenting an extra boundary condition at infinity. Numerical results obtained in the form of velocity distributions and temperature profiles are presented for a range of values of the dimensionless viscoelastic fluid parameter. It is found that for some values of the viscoelastic parameter and some negative values of the mixed convection parameter (opposing flow) the momentum boundary layer separates from the cylinder. Heating the cylinder delays separation and can, if the cylinder is warm enough, suppress the separation completely. Similar to the case of a Newtonian fluid, cooling the cylinder brings the separation point nearer to the lower stagnation point.     

The polytopal association scheme

Summary The polytopal association scheme for PBIB designs is introduced and studied utilizing the concept of clustering of treatments.     

Cabibbo angle and quark masses in a four-quark model of quantum flavordynamics

The Cabibbo angle is related through spontaneous symmetry breaking to the masses of the light quarks in an illustrative model of quantum flavordynamics based on the SU_2L × SU_2R × U₁ flavor gauge group and on four quark flavors. The agreement with experiment is quite good.     

Direct observation of the modulation of the 4f-electron orbital state by strong p-f mixing in CeSb

Low-temperature x-ray diffraction experiment has been carried out to investigate the 4 f-electron state of the low carrier density system CeSb which shows complicated magnetic phase diagrams at low temperatures. The scattering pattern of the satellite peaks observed in the magnetically ordered state AFP3 is explained well by the model which takes into account both the lattice and charge modulations corresponding to the complex magnetic structure. The present result gives direct evidence for the strong modulation of the 4 f-electron orbital state in CeSb due to the combined effect of the strong p-f mixing and carrier localization.     

2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation

Analogs of 1,5-diarylpyrazoles with a novel pharmacophore at N1 were designed, synthesized and evaluated for the in-vitro cyclooxygenase (COX-1/COX-2) inhibitory activity. The variations at/around position-4 of the C-5 phenyl ring in conjunction with a CF3 and CHF2 groups at C-3 exhibited a high degree of potency and selectivity index (SI) for COX-2 inhibition. The in-vivo evaluation of these potent compounds with a few earlier ones indicated the 4-OMe-phenyl analog and the 4-NHMe-phenyl analog with a CF3, and the 4-OEt-phenyl analog with a CHF2 group at C-3 to possess superior potency than celecoxib. In addition to its impressive anti-inflammatory, antipyretic, analgesic and anti-arthritic properties, compound (DRF-4367) was found to possess an excellent pharmacokinetic profile, gastrointestinal (GI) safety in the long-term arthritis study and COX-2 potency in human whole blood assay. Thus, compound was selected as an orally active anti-inflammatory candidate for pre-clinical evaluation.