Progress in development of Nuclotron accelerator complex

The Nuclotron superconducting synchrotron was constructed in 1987–1992 [1]; it is the world’s first synchrotron based on fast cycling “window frame” electromagnets with a superconducting coil. For a design field of dipole magnets of 2 T, the magnetic rigidity is 45 T m, which corresponds to the energy of heavy nuclei (for example, gold) of 4.5 GeV/nucleon. The Nuclotron accelerator complex is currently being upgraded (the Nuclotron-M project); this upgrade is considered a key part of the first stage of fulfilling the new Joint Institute for Nuclear Research (JINR) project: the Nuclotron-based Ion Collider fAcility and Multi-Purpose Detector (NICA/MPD). The most important task of this new project is the preparation of basic Nuclotron systems for its reliable operation as part of the NICA accelerator complex. Basic results of activity on the project, which started in 2007, are presented and the results of the last Nuclotron runs are analyzed.     

Composition and structure of nanoporous silicon layers with galvanically deposited Fe and Co

The morphology and phase composition of porous silicon with galvanically deposited Fe and Co particles were investigated by ultrasoft X-ray emission spectroscopy, X-ray absorption near-edge structure spectroscopy, and scanning electron microscopy. It is shown that iron uniformly covers the surface of porous silicon, whereas cobalt penetrates into pores in the form of nanoparticles. It is established that iron is present mainly in the Fe₂O₃ phase with an admixture of FeO and Fe₃O₄. Cobalt forms a mixture of phases of metallic Co and Co₂O₃.     

Cetyl‐alcohol‐reinforced hollow fiber solid/liquid‐phase microextraction and HPLC–DAD analysis of ezetimibe and simvastatin in human plasma and urine

A new cetyl‐alcohol‐reinforced hollow fiber solid/liquid‐phase microextraction (CA–HF–SLPME) followed by high‐performance liquid chromatography–diode array detection (HPLC–DAD) method was developed for simultaneous determination of ezetimibe and simvastatin in human plasma and urine samples. To prepare the CA–HF–SLPME device, the cetyl‐alcohol was immobilized into the pores of a 2.5 cm hollow fiber micro‐tube and the lumen of the micro‐tube was filled with 1‐octanol with the two ends sealed. Afterwards, the prepared device was introduced into 10 mL of the sample solution containing the analytes with agitation. Under optimized conditions, calibration curves plotted in spiked plasma and urine samples were linear in the ranges of 0.363–25/0.49–25 μg L^?1 for ezetimibe/simvastatin and 0.193–25/0.312–25 μg L^?1 for ezetimibe/simvastatin in plasma and urine samples, respectively. The limit of detection was 0.109/0.174 μg L^?1 for ezetimibe/simvastatin in plasma and 0.058/0.093 μg L^?1 for ezetimibe/simvastatin in urine. As a potential application, the proposed method was applied to determine the concentration of selected analytes in patient plasma and urine samples after medication and satisfactory results were achieved. In comparison with reference methods, the CA–HF–SLPME–HPLC–DAD method demonstrates considerable potential in the biopharmaceutical analysis of selected drugs.     

Chitosan loaded with silver nanoparticles,CS‐AgNPs,using thymus syriacus,wild mint,and rosemary essential oil extracts as reducing and capping agents

The present study describes the green method for the preparation of chitosan loaded with silver nanoparticles (CS‐AgNPs) in the presence of 3 different extracted essential oils. The essential oils play dual roles as reductant and capping agents. The reducing power and DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) assay for the 3 essential oils—Thymus syriacus (T), wild mint (M), and rosemary (R)—have been reported. The preparation of CS‐AgNPs was performed by 2 steps. The 3 previously extracted essential oils have been used as reducing and capping agent in the first step, while in the second step, silver nanoparticles were integrated in chitosan. The integration of AgNPs in the structure of chitosan was confirmed by ultraviolet‐visible, Fourier transform infrared spectroscopy, scanning electron microscopy techniques, and energy dispersive X‐ray. Surface plasmon resonance confirmed the formation of CS‐AgNPs with maximum absorbance at λ_max between 405 ‐ 410 and 410 ‐ 430 nm for colloidal and films of CS‐AgNPs, respectively. The intensity of bands at 3408 cm^?1 in the fourier transform infrared spectroscopy measurements was decreased substantially and shifted slightly to lower frequency (?υ = 43 cm^?1). Scanning electron microscopy shows a spherical morphology of AgNPs with size of 62 nm for both colloidal and film samples, and energy dispersive X‐ray analysis shows peaks confirming AgNPs formation.     

Enantioselective determination of modafinil in pharmaceutical formulations by capillary electrophoresis, and computational calculation of their inclusion complexes

A fast capillary electrophoretic method is described for the separation and determination of the enantiomers of the novel wake-promoting agent, modafinil. Several parameters affecting the separation were studied, including the type and concentration of chiral selector, buffer pH, buffer concentration, voltage and temperature. Good chiral separation of the racemic mixture was achieved in less than 5 min with resolution factor Rs?=?2.51, using a bare fused-silica capillary and a background electrolyte (BGE) of 25 mM H₃PO₄?1 M tris solution; pH 8.0; containing 30 mg mL^?1 of sulfated-β-cyclodextrin (S-β-CD). The separation was carried out in normal polarity mode at 25 ^?C, 18 kV and using hydrostatic injection. Acceptable validation criteria for selectivity, linearity, precision, and accuracy were included. The developed method was successfully applied to the assay of enantiomers of modafinil in pharmaceutical formulations. The computational calculations for the enantiomeric inclusion complexes rationalized the reasons for the different migration times between the modafinil enantiomers.     

X-ray electron probe microanalysis of the reaction zone of thermally stimulated heterovalent anion substitution in the Ga 2III Se 3VI -GaAs solid-phase system

X-ray electron probe microanalysis (EPMA) was used to study the concentration profiles of the main reaction components in the Ga₂Se₃-GaAs heterojunction obtained as a result of thermally stimulated heterovalent anion substitution. It has been found that the quasi-equilibrium and quasi-steady diffusion modes for delivery of chalcogen to the reaction zone are different with respect to the kinetics of the A₂^IIIC₃^VI layer growth. Independent of this, the concentration profiles of the reaction elements are self-organized with time, which allows heterostuctures with a sharp interphase boundary to be reproduced.     

A self-similar problem dealing with the one-dimensional collision of two half spaces of a nonlinear-elastic material

Translated from Zhurnal Prikladnoi Mekhaniki i Tekhnicheskoi Fiziki, Vol. 30, No. 6, pp. 146–150, November–December, 1989.     

Kinetic and analytical study on precipitation reactions with110AgNO3 of some di (β-chloroethyl) amine derivates and hydrochlorides with esters of N-(p-aminobenzoyl)-L-aspartic acid as carriers from dimethylformamide-water solution

The kinetics of precipitation reactions with¹¹⁰AgNO₃ of some di (β-chlorethyl) amine derivates and hydrochlorides with esters of N-(p-aminobenzoyl)-L-aspartic acid as carriers in dimethylformamide-water mixture, were studied. The rate constants of these reactions were of the order of 10^?4 1 · mol^?1 · min^?1. The concentrations of the corresponding hydrochloride solutions were measured by radiometric titration with¹¹⁰AgNO₃ solution of given concentration.