64CuCl2 PET Imaging of 4T1-Related Allograft of Triple-Negative Breast Cancer in Mice

⁶⁴CuCl₂ is an economic radiotracer for oncologic PET investigations. In the present study, we characterized the uptake of ⁶⁴CuCl₂ in vivo by µPET/CT in an allograft 4T1-related mouse model (BALB/c) of advanced breast cancer. ¹⁸F-FDG was used as a comparator. Twenty-two animals were imaged 7–9 days following 4T1-cell implantation inside mammary glands. Dynamic ⁶⁴CuCl₂ µPET/CT acquisition or iterative static images up to 8 h p.i. were performed. Animal biodistribution and tumor uptake were first evaluated in vivo by µPET analysis and then assessed on tissue specimens. Concerning ¹⁸F-FDG µPET, a static acquisition was performed at 15 min and 60 min p.i. Tumor ⁶⁴CuCl₂ accumulation increased from 5 min to 4 h p.i., reaching a maximum value of 5.0 ± 0.20 %ID/g. Liver, brain, and muscle ⁶⁴CuCl₂ accumulation was stable over time. The tumor-to-muscle ratio remained stable from 1 to 8 h p.i., ranging from 3.0 to 3.7. Ex vivo data were consistent with in vivo estimations. The ¹⁸F-FDG tumor accumulation was 8.82 ± 1.03 %ID/g, and the tumor-to-muscle ratio was 4.54 ± 1.11. ⁶⁴CuCl₂ PET/CT provides good characterization of the 4T1-related breast cancer model and allows for exploration of non-glycolytic cellular pathways potentially of interest for theragnostic strategies.     

An optimal gradient method for smooth strongly convex minimization

Mathematical Programming - We present an optimal gradient method for smooth strongly convex optimization. The method is optimal in the sense that its worst-case bound on the distance to an optimal...     

Stereoselective Synthesis of Glycosyl Cyanides by TMSOTf-Mediated Ring Opening of 1,6-Anhydro Sugars

We describe herein a convenient access to glycosyl cyanides by way of TMSCN ring opening of 1,6-anhydro sugars mediated by TMSOTf with modest to high stereocontrol in the D-gluco, D-galacto and D-manno series. The reaction is tolerant to various functional groups including free alcohols, alkenes and terminal alkynes. The straightforward synthesis of a constrained analogue of 1-cyano-D-glucal with a 3,6-anhydro sugar framework is presented to illustrate the interest of the TMSCN ring-opening reaction.     

Statistical self-organization of an assembly of interacting walking drops in a confining potential

The European Physical Journal E - In this study, polyurethane (PU)-based xerogels were synthesized by using the biobased polyol derived from chaulmoogra seed oil. These polyol was used for the...     

Principled analyses and design of first-order methods with inexact proximal operators

Mathematical Programming - Proximal operations are among the most common primitives appearing in both practical and theoretical (or high-level) optimization methods. This basic operation typically...