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81.
Janina Hahn Volkan Filiz Sofia Rangou Juliana Clodt Adina Jung Kristian Buhr Clarissa Abetz Volker Abetz 《Journal of Polymer Science.Polymer Physics》2013,51(4):281-290
For the first time the combination of solution casting and solvent–nonsolvent exchange (phase inversion) has been applied to generate asymmetric membranes with highly ordered hexagonally packed cylinders with perpendicular orientation composed of polystyrene-block-poly(ethylene oxide). The influence of parameters like solvent composition and evaporation time on the membrane formation is presented. The development is based on a study of the solution behavior by dynamic light scattering and the precipitation behavior of the cylinder forming diblock copolymer by turbidity measurements from different solvent and nonsolvent systems. The water flux properties, as an important membrane characteristic, show a time dependent behavior, due to swelling of the polyethylene oxide blocks. The morphologies of the membranes are imaged by scanning electron microscopy. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2013 相似文献
82.
83.
Laura C. E. Manoliu Eliza C. Martin Adina L. Milac Laurentiu Spiridon 《Molecules (Basel, Switzerland)》2021,26(16)
Alzheimer’s disease is a neurodegenerative disorder incompatible with normal daily activity, affecting one in nine people. One of its potential targets is the apelin receptor (APJR), a G-protein coupled receptor, which presents considerably high expression levels in the central nervous system. In silico studies of APJR drug-like molecule binding are in small numbers while high throughput screenings (HTS) are already sufficiently many to devise efficient drug design strategies. This presents itself as an opportunity to optimize different steps in future large scale virtual screening endeavours. Here, we ran a first stage docking simulation against a library of 95 known binders and 3829 generated decoys in an effort to improve the rescoring stage. We then analyzed receptor binding site structure and ligands binding poses to describe their interactions. As a result, we devised a simple and straightforward virtual screening Stage II filtering score based on search space extension followed by a geometric estimation of the ligand—binding site fitness. Having this score, we used an ensemble of receptors generated by Hamiltonian Monte Carlo simulation and reported the results. The improvements shown herein prove that our ensemble docking protocol is suited for APJR and can be easily extrapolated to other GPCRs. 相似文献
84.
The synthesis of multi-walled carbon nanotubes (MWNTs) by catalytic pyrolysis of the phenol-formaldehyde resins 总被引:1,自引:0,他引:1
Ioan Stamatin Adina Morozan Anca Dumitru V. Ciupina G. Prodan J. Niewolski H. Figiel 《Physica E: Low-dimensional Systems and Nanostructures》2007,37(1-2):44
A series of carbon nanomaterials, particularly multi-walled carbon nanotubes (MWNT), are obtained as products from catalytic pyrolysis of the cross-linked phenol-formaldehyde resins with different ferrocene under inert atmosphere. The morphology and structure of the samples were evaluated by TEM and XRD techniques. CNTs morphology is dependent on the iron nanoparticles and their forms (Fe, Fe3C) resulted from ferrocene decomposition. The amount of nanotubes increases with iron content released from ferrocene catalyst during the pyrolysis process. Fe3C nanoparticles drive the nucleation and the growth of carbon nanotubes during the pyrolysis process. Long (up to microns) well-defined MWNTs with small defects, ropes and disordered carbon are representatives in the pyrolyzed resins composition. 相似文献
85.
Dr. Michele Anselmi Dr. Adina Borbély Dr. Eduard Figueras Carmela Michalek Dr. Isabell Kemker Prof. Dr. Luca Gentilucci Prof. Dr. Norbert Sewald 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(3):1015-1022
Most anticancer agents are hydrophobic and can easily penetrate the tumor cell membrane by passive diffusion. This may impede the development of highly effective and tumor-selective treatment options. A hydrophilic β-glucuronidase-cleavable linker was used to connect the highly potent antimitotic agent cryptophycin-55 glycinate with the αvβ3 integrin ligand c(RGDfK). Incorporation of the self-immolative linker containing glucuronic acid results in lower cytotoxicity than that of the free payload, suggesting that hydrophilic sugar linkers can preclude passive cellular uptake. In vitro drug-release studies and cytotoxicity assays demonstrated the potential of this small molecule–drug conjugate, providing guidance for the development of therapeutics containing hydrophobic anticancer drugs. 相似文献
86.
Maria Antonia Tnase Maria Marinescu Petruta Oancea Adina Rducan Catalin Ionut Mihaescu Elvira Alexandrescu Cristina Lavinia Nistor Luiza-Izabela Jinga Lia Mara Diu Cristian Petcu Ludmila Otilia Cinteza 《Molecules (Basel, Switzerland)》2021,26(7)
In the present work, the properties of ZnO nanoparticles obtained using an eco-friendly synthesis (biomediated methods in microwave irradiation) were studied. Saponaria officinalis extracts were used as both reducing and capping agents in the green nanochemistry synthesis of ZnO. Inorganic zinc oxide nanopowders were successfully prepared by a modified hydrothermal method and plant extract-mediated method. The influence of microwave irradiation was studied in both cases. The size, composition, crystallinity and morphology of inorganic nanoparticles (NPs) were investigated using dynamic light scattering (DLS), powder X-ray diffraction (XRD), SEM-EDX microscopy. Tunings of the nanochemistry reaction conditions (Zn precursor, structuring agent), ZnO NPs with various shapes were obtained, from quasi-spherical to flower-like. The optical properties and photocatalytic activity (degradation of methylene blue as model compound) were also investigated. ZnO nanopowders’ antibacterial activity was tested against Gram-positive and Gram-negative bacterial strains to evidence the influence of the vegetal extract-mediated synthesis on the biological activity. 相似文献
87.
Ocsana Opri Ildiko Lung Maria-Loredana Soran Adina Stegarescu Tatiana Cesco Aliona Ghendov-Mosanu Paula Podea Rodica Sturza 《Molecules (Basel, Switzerland)》2022,27(5)
The purpose of this study was to evaluate the sun protection factor (SPF) of cosmetic emulsions with the addition of hydroalcoholic apple extract. First, the total polyphenolic content, the antioxidant activity and SPF properties of the extracts obtained by sonication and refluxing were evaluated. The two extraction methods were improved using the central composite design. For cosmetic emulsion that contained a different concentration of apple extract (10–40%), a SPF value between 0.51 and 0.90 was obtained. The most efficient apple extract was obtained by reflux using 50% ethanol and a 60 min extraction time. The concentrated extract was incorporated in a cosmetic emulsion whose SPF maximum was 0.90. Accordingly, due to photoprotective properties, the apple extract can be a candidate for use in cosmetic formulations. 相似文献
88.
Silvia Ptruic Ersilia Alexa Diana Obitioiu Ileana Cocan Isidora Radulov Adina Berbecea Roxana Nicoleta Lazr Eliza Simiz Nicoleta Maria Vicar Anca Hulea Drago Moraru 《Molecules (Basel, Switzerland)》2022,27(13)
Honey is a natural product with multiple health benefits. The paper presents the chemical characterization and the antioxidant and antimicrobial potential of ten types of honey (knotweed, linden, wild cherry, acacia, honeydew, oilseed rape, sunflower, phacelia, plain polyflora and hill polyflora) from the Banat region, Romania. We studied the water content, dry matter, impurities, acidity and pH of honey. We also determined the content of reducing sugar, minerals and flavonoids and the total phenolic content. All honey samples analysed showed good nutritional characteristics according to the standard codex for honey. From the analysis of the mineral content of the honey samples, we observed a variability in the macro and microminerals, influenced by the botanical origin, ranging between 0.25% (wild cherry honey) and 0.54% (honeydew). The toxic metals’ (Cd and Pb) levels met the standard for almost all samples analysed except for knotweed. The flavonoid content of the samples ranged from 9.29 mg QE/100 g for wild cherry honey to 263.86 mg QE/100 g for linden honey, and for polyphenols between 177.6 mgGAE/100 g for acacia honey and 1159.3 mgGAE/100 g for honeydew. The best antioxidant capacity was registered in the case of linden honey (79.89%) and honeydew (79.20%) and the weakest in acacia (41.88%) and wild cherries (50.4%). All studied honey samples showed antimicrobial activity, depending on the type of honey, concentration and strain analysed. The novelty of this study is given by the complex approach of the study of honey quality, both from the perspective of chemical attributes and the evaluation of the antimicrobial potential on specific strains in correlation with the botanical and geographical origin of the analyzed area. 相似文献
89.
Dr. Roman Voloshchuk Prof. Dr. Daniel T. Gryko Dr. Maciej Chotkowski Adina I. Ciuciu Dr. Lucia Flamigni 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(46):14845-14859
An assembly has been synthesised that consists of four units: a meso‐substituted corrole (C3), perylene bisimide (PI), and two electron‐rich triphenylamine (DPA) units. PI is connected through a 1,4‐phenylene bridge to C3, whereas the two DPA units are linked to C3 through a diphenyl ether linkage, which is used for the first time to connect the various moieties. Various synthetic strategies were elaborated, and the chosen one afforded the final system in six steps in an overall yield of 6 %. The resulting assembly, made of three different units, was named a “triad”. Excitation of the corrole (C3) or perylene bisimide (PI) units led to the charge‐separated state DPA‐C3+‐PI? with a rate k>1011 s?1 in benzonitrile and dichloromethane (CH2Cl2) or with k of the order of 1010 s?1 in toluene. The latter charge‐separated state decayed to the ground state with a rate k=1.8×109 s?1 in toluene. In the polar solvents benzonitrile and dichloromethane, recombination to the ground state competes with a charge shift to form the distal charge‐separated state, DPA+‐C3‐PI?, the formation of which occurs with a yield of 50 %. Recombination to the ground state of DPA+‐C3‐PI? occurs with a rate k=5×107 s?1 in CH2Cl2 and k=2×107 s?1 in benzonitrile. 相似文献
90.