Observation of B Meson decays to b1pi and b1K

We present the results of searches for decays of B mesons to final states with a b1 meson and a charged pion or kaon. The data, collected with the BABAR detector at the Stanford Linear Accelerator Center, represent 382x10(6) BB[over ] pairs produced in e+e- annihilation. The results for the branching fractions are, in units of 10(-6), B(B+-->b1(0)pi+)=6.7+/-1.7+/-1.0, B(B+-->b1(0)K+)=9.1+/-1.7+/-1.0, B(B0-->b1(-/+)pi(+/-))=10.9+/-1.2+/-0.9, and B(B0-->b1(-)K+)=7.4+/-1.0+/-1.0, with the assumption that B(b1-->omega pi)=1. We also measure charge and flavor asymmetries A(ch)(B+-->b1(0)pi+)=0.05+/-0.16+/-0.02, Ach(B+-->b1(0)K+)=-0.46+/-0.20+/-0.02, A(ch)(B0-->b1(-/+)pi(+/-))=-0.05+/-0.10+/-0.02, C(B0-->b1(-/+)pi(+/-))=-0.22+/-0.23+/-0.05, DeltaC(B0-->b1(-/+)pi(+/-))=-1.04+/-0.23+/-0.08, and A(ch)(B0-->b1(-)K+)=-0.07+/-0.12+/-0.02. The first error quoted is statistical, and the second systematic.     

Amplitude analysis of the B+/--->phiK*(892)+/- decay

We perform an amplitude analysis of B+/--->phi(1020)K*(892)+/- decay with a sample of about 384 x 10(6) BB[over ] pairs recorded with the BABAR detector. Overall, twelve parameters are measured, including the fractions of longitudinal fL and parity-odd transverse f perpendicular amplitudes, branching fraction, strong phases, and six parameters sensitive to CP violation. We use the dependence on the Kpi invariant mass of the interference between the JP=1(-) and 0+ Kpi components to resolve the discrete ambiguity in the determination of the strong and weak phases. Our measurements of fL=0.49+/-0.05+/-0.03, f perpendicular=0.21+/-0.05+/-0.02, and the strong phases point to the presence of a substantial helicity-plus amplitude from a presently unknown source.     

Effects due to body-forces and body-couples in the interior of a micropolar elastic half-space—I

A general solution of the equilibrium equations is obtained for a half-space with a fixed boundary and arbitrary but axisymmetric distribution of body forces and body couples in the interior of the half-space. Few particular cases have been investigated in detail. The stresses have been obtained at the boundary and the displacements have been obtained in the interior of the half-space. Numerical results have been displayed graphically.

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Zusammenfassung Eine allgemeine lösung für Gleichgewicht eines Halbraums mit festem Rand und einer beliebigen, aber antisymmetrischen Verteilung von Körperkräften und Körpermomenten im Inneren wird gefunden. Einige Spezialfälle wurden ansführlich erforscht. Die Spannungen am Rand und die Verschiebungen im Inneren des Halbraums wurden erhalten. Numerische Resultate wurden graphisch dargestellt.

     

Purification of transferrin by magnetic immunoaffinity beads

Immunoaffinity adsorbent for transferrin (Tf) purification was prepared by immobilizing anti‐transferrin (Anti‐Tf) antibody on magnetic monosizepoly(glycidyl methacrylate) beads, which were synthesized by dispersion polymerization technique in the presence of Fe₃O₄nanopowder and obtained with an average size of 2.0 μm. The magnetic poly(glycidyl methacrylate) (mPGMA) beads were characterized by Fourier transform infrared spectroscopy, swelling tests, scanning electron microscopy, electron spin resonance spectroscopy, thermogravimetric analysis and zeta sizing analysis. The density and swelling ratio of the beads were 1.08 g/cm³ and 52%, respectively. Anti‐Tf molecules were covalently coupled through epoxy groups of mPGMA. Optimum binding of anti‐Tf was 2.0 mg/g. Optimum Tf binding from aqueous Tf solutions was determined as 1.65 mg/g at pH 6.0 and initial Tf concentration of 1.0 mg/mL. There was no remarkable loss in the Tf adsorption capacity of immunoaffinity beads after five adsorption–desorption cycles. Tf adsorption from artificial plasma was also investigated and the purity of the Tf molecules was shown with gel electrophoresis studies.     

Triazine herbicide imprinted monolithic column for capillary electrochromatography

Trietazine was selectively separated from aqueous solution containing the competitor molecule cyanazine, which is similar in size and shape to the template molecule. Structural features of the molecularly imprinted column were figured out by SEM. The influence of the mobile‐phase composition, applied electrical field, and pH of the mobile phase on the recognition of trietazine by the imprinted monolithic polymer has been evaluated, and the imprint effect in the trietazine‐imprinted monolithic polymer was demonstrated by an imprinting factor. The optimized monolithic column resulted in separation of trietazine from a structurally related competitor molecule, cyanazine. In addition, fast separation was obtained within 6 min by applying higher electrical field, with the electrophoretic mobility of 2.97 × 10^?8 m²V^?1s^?1 at pH 11.0.     

Synthesis, characterization and antimicrobial studies of mixed ligand silver(I) complexes of triphenylphosphine and heterocyclic thiones: Crystal structure of bis[{(μ-diazinane-2-thione)(diazinane-2-thione)(triphenylphosphine)silver(I) nitrate}]

Mixed ligand silver(I) complexes of triphenylphosphine and heterocyclic thiones (imidazolidine-2-thione (Imt), diazinane-2-thione (Diaz) and 2-mercaptopyridine (Mpy)) having the general formulae [(Ph₃P)Ag(thione)₂]NO₃ and [(Ph₃P)₂Ag(thione)]NO₃ were prepared and characterized by elemental analysis, IR and NMR (¹H, ¹³C and ³¹P) spectroscopic methods. The crystal structure of one of the complexes, [Ag(Ph₃P)(Diaz)₂]₂(NO₃)₂ (1) was determined by X-ray crystallography. The title complex (1) is dinuclear, having each silver atom coordinated to three thione sulfur atoms of Diaz and to one phosphorus atom of PPh₃ in a nearly tetrahedral environment, with an average P-Ag-S bond angle of 108.5°. The spectral data of the complexes are consistent with sulfur coordination of the thiones to silver(I). Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentrations and the results showed that the complexes exhibit a wide range of activity against two gram-negative bacteria (E. coli, P. aeruginosa) and molds (A. niger, P. citrinum), while the activities were poor against yeasts (C. albicans, S. cerevisiae).     

Monosize microbeads for pseudo-affinity adsorption of human insulin

Affinity adsorption technique is increasingly used for protein purification, separation and other biochemical applications. Therapeutic molecules such as antibodies, cytokines, therapeutic DNA and plasma proteins must be purified before characterization and utilization. The aim of this study was to prepare micronsized spherical polymeric beads and to investigate the extent of their human insulin adsorption capability. Monosize poly(ethylene glycol dimethacrylate-N-methacryloyl-(L)-histidine) [poly(EDMA-MAH)] beads were prepared by modified suspension copolymerization. Functional monomer (MAH) was synthesized using methacryloyl chloride and L-histidine. The beads were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, swelling test and elemental analysis. MAH incorporation into monosize polymeric beads, having an average size around 2-3 μm, was estimated as 55.3 μmol MAH/g bead. Equilibrium swelling ratios of poly(EDMA-MAH) and poly(EDMA) beads were 65% and 55%, respectively. Adsorption experiments were performed under different conditions (i.e., pH, temperature, protein concentration and ionic strength). It was found that adsorption characteristics are strongly depend on these conditions. Maximum insulin adsorption capacity was achieved as 24.7 mg insulin/g poly(EDMA-MAH) beads. Results were well fitted to the Langmuir isotherm model. Compared with poly(EDMA-MAH), nonspecific insulin adsorption onto poly(EDMA) beads was very low (0.61 mg insulin/g bead) and can be negligible. It was observed that insulin could be repeatedly adsorbed and desorbed (at least 10 times) without significant loss in adsorption capacity.     

Interaction energy‐based drug–receptor interaction study of metal–bicyclam complexes

Bicyclams inhibit HIV replication by binding to the CXCR4 chemokine receptor, which is the main coreceptor for gp120 used by X4, T‐tropic strains of HIV for membrane fusion and cell entry. Bicyclam AMD3100 mainly interacts with the aspartic acid residues namely Asp171 and Asp262, which are located at the extracellular ends in the CXCR4 coreceptor. Incorporation of some metal ions by the macrocyclic rings of bicyclam enhances its binding affinity to the CXCR4 receptor and enhances their anti‐HIV activity because the acetate can make a strong coordination bond to the metal and one weaker hydrogen bond to nitrogen in the cyclam ring. The interaction energy (E_int) between 150 metal–bicyclam complexes and aspartic acid has been evaluated. The metal–bicyclam complexes are obtained by the incorporation of six metal ions namely Fe³⁺, Co³⁺, Ni²⁺, Cu²⁺, Zn²⁺, and Pd²⁺ in 25 well‐known bicyclams including AMD3100. In most of the cases, Fe and Co–bicyclam complexes interact best with aspartic acid. The anti‐HIV activity of metal–bicyclam complexes can be predicted on the basis of interaction energy before the synthesis of the metal–bicyclam complex. On the basis of interaction energy, the anti‐HIV activity of bicyclam complexes can be predicted in advance to their synthesis. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2011