AbstractA new sesquiterpene lactone geigerianoloide (
1) and four known flavonoids axillarin (
2), quercetin (
3), 3-methoxy-5,7,3',4'-tetrahydroxy-flavone (
4) and hispidulin (
5) were isolated from
Geigeria alata (DC) Oliv. & Hiern. (Asteraceae). Structures were deduced using
1H- and
13C- NMR spectroscopy, mass spectrometry, while the structure of compound
1 was also deduced using X-ray crystallography technique.
Geigeria alata is traditionally used for diabetes, therefore compounds were tested for anti-glycation activity, in which compounds
2 and
3 showed potent activities (IC
50 values of 246.97?±?0.83 and 262.37?±?0.22
µM, respectively) compared to IC
50 value 294.50?±?1.5
µM of rutin. Moreover, compound
4 exhibited a comparable activity to rutin (IC
50?=?293.28?±?1.34
µM). Compound
5 showed a weak activity.Compounds
2,
3, and
4 exhibited potent DPPH radical scavenging activity (IC
50?=?0.1?±?0.00, 0.13?±?0.00 and 0.15?±?0.01
µM, respectively). Compounds
2,
3, and
4 demonstrated significant superoxide anion scavenging activity with IC
50 values of 0.14?±?0.001, 0.17?±?0.00, and 0.11?±?0.006
µM, respectively.
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