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101.
Enamides, dienamides, and enynamides are important building blocks in synthetic, biological, and medicinal chemistry as well as materials science. Despite the extensive breath of their potential utility in synthetic chemistry, there is a lack of simple, high-yielding methods to deliver them efficiently and as single isomers. In this paper, we present a novel, protecting group free, efficient, and stereoselective approach to the generation of β-halo-enamides. The methodology presented provides a robust synthetic platform from which E- or Z-enamides can be generated in good yields and with complete stereocontrol. 相似文献
102.
Fontana A Tramice A Cutignano A D'Ippolito G Gavagnin M Cimino G 《The Journal of organic chemistry》2003,68(6):2405-2409
Biogenesis of the enantiomeric sesquiterpenes 1 and 5 of the marine nudibranch Doriopsilla areolata was investigated by feeding of [1-(13)C]glucose, [1,2-(13)C(2)]glucose, and [1,2-(13)C(2)]acetate. Evidence is presented that supports de novo origin of both compounds via mevalonic acid. 相似文献
103.
The ommochrome pigment present in the eyes of Loligo Vulgaris was extracted with a butanol-acetic acid-hydrochloric acid solution. The extraction mixture was examined before and after irradiation by visible light. A phenoxazinone ring opening together with a photo-induced solvent addition, causing a yellow-red batho-chromic shift, were observed and a plausible explanation of the process has been carried out and is reported on the basis of the isolated products. 相似文献
104.
Joseph F. Mucci 《Foundations of Physics》1974,4(1):91-95
Mathematical expressions for the entropyS, the average information gained per trial (ī) from information theory, and the de Broglie cyclical action integralA from his reinterpretation of wave mechanics are shown to be similar. The importance of this observation in our understanding ofS andī is considered. Furthermore, the similarity in the mathematical form of these functions indicates a possible route to further interpretation of de Broglie'sA and the nature of his “hidden thermostat.” 相似文献
105.
Adele Bolognese Rosa Liberatore Wolfram Schfer 《Journal of heterocyclic chemistry》1989,26(4):1083-1087
The oxidation of 2-amino-4-methylphenol 1 , by ferricyanide, in acetic acid yields benzoquinonimine 2 , phenoxazinonimine 3 and 4 , triphenodioxazines 5 and phenoxazinone 6 . The reaction mechanism seems to start with an electrophilic substitution of the quinonimine, from 1 , on the electron rich 1 , rather than with a nucleophilic attack of 1 on the arising quinonimine. 相似文献
106.
d'Ippolito G Cutignano A Briante R Febbraio F Cimino G Fontana A 《Organic & biomolecular chemistry》2005,3(22):4065-4070
An unprecedented series of C16 oxylipins (1-8) has been characterized from the marine diatom Thalassiosira rotula. Absolute stereochemistry of the major alcohols 1 and 3 was determined to be 9S by spectroscopic and chemical methods. All the described products are formally derived by unprecedented enzymatic oxidation of C16 fatty acids. Conversion of hexadeca-6,9,12-trienoic acid (C16:3 omega-4) into 3 unequivocally established the occurrence of (at least) a specific 9S-oxygenase activity. To the best of our knowledge, the present data reveal for the first time the existence of an organic network of oxygenase-mediated transformations that require C16 fatty acids as substrates in living cells. 相似文献
107.
Crescenzi O Correale G Bolognese A Piscopo V Parrilli M Barone V 《Organic & biomolecular chemistry》2004,2(11):1577-1581
Carbon and proton NMR spectra of several substituted 5H-pyrido[3,2-a]-, 5H-pyrido[2,3-a]phenoxazin-5-ones and 3H-phenoxazin-3-one derivatives have been assigned, and the experimental chemical shifts have been compared with the results of density functional calculations employing large basis sets. Solvent effects were explored by means of the polarizable continuum method (PCM), while the (limited) side-chain flexibility of the compounds has been addressed by Boltzmann averaging of the computed spectral parameters over different conformational minima. Overall, the calculated shifts reproduce well the experiment results; thus, the computational procedure represents a feasible and useful complement to multidimensional NMR experiments in the assignment process. 相似文献
108.
Rachel Neale Anne Russell H. Konrad Muller Adele Green 《Photochemistry and photobiology》1997,66(2):260-264
This study examined the effects of chronic and current sun exposure on the number of Langerhans cells in epidermal sheets of UV-exposed and unexposed skin of the arms and assessed the effect of sunscreens. Participants were enrolled in a skin cancer prevention trial and had been using sunscreen daily for the previous 3 years. There were significantly fewer Langerhans cells on the exposed (463 cells/mm2) than on the unexposed forearm (528 cells/mm2) (P = 0.0001). High sun exposure in the previous 2 weeks and a history of predominantly outdoor occupations were both associated with a reduced number of Langerhans cells, although age and other biological indicators of chronic exposure were not associated. Sunscreen use was protective against the effects of current but not chronic sun exposure, with a suggestion of a greater effect at higher levels of exposure. Unexpectedly, people with a past history of nonmelanoma skin cancer had more Langerhans cells in both the exposed and the unexposed skin. These results emphasize the need for continued public health education to protect the immune system from the damaging effects of UV radiation . 相似文献
109.
Adele Cutignano Daniela Blihoghe Angelo Fontana Guido Villani Giuliana d''Ippolito Guido Cimino 《Tetrahedron》2007,63(52):12935-12939
A novel regular polypropionate skeleton has been characterized in two new pyrones, named fusaripyrone A (1) and fusaripyrone B (2), from the lipid extracts of the mollusc Haminoea fusari. Here we report elucidation of the polyketide structures of 1 and 2, isolated as either natural products or isomeric pairs of -/γ-pyrone methyl derivatives. 相似文献
110.
Yung-Ching Chien Alfonso Mucci Jeanne Paquette S Kelly Sears Hojatollah Vali 《Microscopy and microanalysis》2006,12(4):302-310
The bulk morphology and surface features that developed upon precipitation on micrometer-size calcite powders and millimeter-size cleavage fragments were imaged by three different microscopic techniques: field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM) of Pt-C replicas, and atomic force microscopy (AFM). Each technique can resolve some nanoscale surface features, but they offer different ranges of magnification and dimensional resolutions. Because sample preparation and imaging is not constrained by crystal orientation, FE-SEM and TEM of Pt-C replicas are best suited to image the overall morphology of microcrystals. However, owing to the decoration effect of Pt-C on the crystal faces, TEM of Pt-C replicas is superior at resolving nanoscale surface structures, including the development of new faces and the different microtopography among nonequivalent faces in microcrystals, which cannot be revealed by FE-SEM. In conjunction with SEM, Pt-C replica provides the evidence that crystals grow in diverse and face-specific modes. The TEM imaging of Pt-C replicas has nanoscale resolution comparable to AFM. AFM yielded quantitative information (e.g., crystallographic orientation and height of steps) of microtopographic features. In contrast to Pt-C replicas and SEM providing three-dimensional images of the crystals, AFM can only image one individual cleavage or flat surface at a time. 相似文献