2pi ambiguity-free optical distance measurement with subnanometer precision with a novel phase-crossing low-coherence interferometer

We report a highly accurate phase-based technique for measuring arbitrarily long optical distance with subnanometer precision. The method employs a Michelson interferometer with a pair of harmonically related light sources, one cw and the other low coherence. By slightly detuning (~2 nm) the center wavelength of the low-coherence source between scans of the target sample, we can use the phase relationship between the heterodyne signals of the cw and the low-coherence light to measure the separation between reflecting interfaces with subnanometer precision. As this technique is completely free of 2pi ambiguity, an issue that plagues most phase-based techniques, it can be used to measure arbitrarily long optical distances without loss of precision. We demonstrate one application of this technique, the high-precision determination of the differential refractive index.     

The Effect of the Protein Synthesis Entropy Reduction on the Cell Size Regulation and Division Size of Unicellular Organisms

The underlying mechanism determining the size of a particular cell is one of the fundamental unknowns in cell biology. Here, using a new approach that could be used for most of unicellular species, we show that the protein synthesis and cell size are interconnected biophysically and that protein synthesis may be the chief mechanism in establishing size limitations of unicellular organisms. This result is obtained based on the free energy balance equation of protein synthesis and the second law of thermodynamics. Our calculations show that protein synthesis involves a considerable amount of entropy reduction due to polymerization of amino acids depending on the cytoplasmic volume of the cell. The amount of entropy reduction will increase with cell growth and eventually makes the free energy variations of the protein synthesis positive (that is, forbidden thermodynamically). Within the limits of the second law of thermodynamics we propose a framework to estimate the optimal cell size at division.     

Probabilistic Predictions with Federated Learning

Probabilistic predictions with machine learning are important in many applications. These are commonly done with Bayesian learning algorithms. However, Bayesian learning methods are computationally expensive in comparison with non-Bayesian methods. Furthermore, the data used to train these algorithms are often distributed over a large group of end devices. Federated learning can be applied in this setting in a communication-efficient and privacy-preserving manner but does not include predictive uncertainty. To represent predictive uncertainty in federated learning, our suggestion is to introduce uncertainty in the aggregation step of the algorithm by treating the set of local weights as a posterior distribution for the weights of the global model. We compare our approach to state-of-the-art Bayesian and non-Bayesian probabilistic learning algorithms. By applying proper scoring rules to evaluate the predictive distributions, we show that our approach can achieve similar performance as the benchmark would achieve in a non-distributed setting.     

Diffusion Model of a Non-Integer Order PIγ Controller with TCP/UDP Streams

In this article, a way to employ the diffusion approximation to model interplay between TCP and UDP flows is presented. In order to control traffic congestion, an environment of IP routers applying AQM (Active Queue Management) algorithms has been introduced. Furthermore, the impact of the fractional controller PIγ and its parameters on the transport protocols is investigated. The controller has been elaborated in accordance with the control theory. The TCP and UDP flows are transmitted simultaneously and are mutually independent. Only the TCP is controlled by the AQM algorithm. Our diffusion model allows a single TCP or UDP flow to start or end at any time, which distinguishes it from those previously described in the literature.     

Gamma radiation from the209Bi(3He, 3nγ)209at reaction

Gamma-radiation from the reactions of 28 MeV and 26 MeV³He-ions on the²⁰⁹Bi target has been studied by means of Ge(Li) detectors. Individual observed prompt -ray transitions have been assigned to the corresponding reactions. The results of previous studies of the²⁰⁹At nucleus have been verified and completed. Two new levels at energies of 640 keV and 1270·5 keV have been introduced. Additionally, 15 new transitions have been observed which could belong to²⁰⁹At. The²⁰⁹At level structure is discussed in terms of nuclear models.     

The second order optical potential for theπd system at the threshold

The second order optical potential for thed system is derived in the framework of the Watson formalism and applied to the calculation of the 1s-state energy shift of the atom and thed scattering lengtha _d . The results are in good agreement with those of the Faddeev type calculations.The authors wish to thank V. B. Belyaev, R. Mach, M. G. Sapozhnikov and R. A. Eramzhyan for stimulating discussions and helpful advice.     

Small gold nanoparticles presenting linear and looped Cilengitide analogues as radiosensitizers of cells expressing α<Subscript>ν</Subscript>β<Subscript>3</Subscript> integrin

This work uses linear and looped RGDfV sequences attached to the surface of small (1.8 nm in diameter) gold nanoparticles (AuNPs) to enhance the radiosensitizating effects of Cilengitide, a cyclic RGDf (NMe)V pentapeptide that targets α_vβ₃ integrin which is overexpressed in certain cancers. Following synthesis and purification, the AuNPs were evaluated in vitro against HUVEC, H460, and MCF7 cells in clonogenic assays using a ¹³⁷Cs irradiator. Untargeted AuNPs induced no significant dose enhancement factors (DEFs) in any of the cell types when compared to radiation treatment alone, whereas all evaluated AuNPs functionalized with targeting peptides performed at least as well as controls (irradiation after Cilengitide treatment). The observed DEFs also suggest that cyclizing the linear peptides into more spatially constrained, looped structures may facilitate target binding. These greater dose enhancements merit future in vivo studies of drug-AuNP conjugates to assess the ability of the nanostructures to provide an improved therapeutic benefit over treatment with drug candidates and radiation alone.

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Improved direct measurement of the parity-violation parameter Ab using a mass tag and momentum-weighted track charge

We present an improved direct measurement of the parity-violation parameter A(b) in the Z boson-b-quark coupling using a self-calibrating track-charge technique applied to a sample enriched in Z-->bb events via the topological reconstruction of the B hadron mass. Manipulation of the Stanford Linear Collider electron-beam polarization permits the measurement of A(b) to be made independently of other Z-pole coupling parameters. From the 1996-1998 sample of 400,000 hadronic Z decays, produced with an average beam polarization of 73.4%, we find A(b)=0.906+/-0.022(stat)+/-0.023(syst).     

Arytenoid Cartilage Dislocation: A 20-year Experience

SUMMARY: Arytenoid cartilage dislocation is an infrequently diagnosed cause of vocal fold immobility. Seventy-four cases have been reported in the literature to date. Intubation is the most common origin, followed by external laryngeal trauma. Decreased volume and breathiness are the most common presenting symptoms. We report on 63 patients with arytenoid cartilage dislocation treated by the senior author (RTS) since 1983. Significantly more posterior than anterior dislocations were represented. Although reestablishing joint mobility is difficult, endoscopic reduction should be considered to align the heights of the vocal processes. This process may result in significant voice improvement even long after the dislocation. Strobovideolaryngoscopy, laryngeal electromyography, and laryngeal computed tomography (CT) imaging are helpful in the evaluation of patients with vocal fold immobility to help distinguish arytenoid cartilage dislocation from vocal fold paralysis. Familiarity with signs and symptoms of arytenoid cartilage dislocation and current treatment techniques improves the chances for optimal therapeutic results.     

Kaon pair production close to threshold

The total cross section of the reaction pp→ppK⁺K⁻$pp\to pp{K}^{+}{K}^{-}$ has been measured at excess energies Q=10 MeV$Q=10\text{MeV}$ and 28 MeV with the magnetic spectrometer COSY-11. The new data show a significant enhancement of the total cross section compared to pure phase space expectations or calculations within a one boson exchange model. In addition, we present invariant mass spectra of two particle subsystems. While the K⁺K⁻$K^{+}{K}^{-}$ system is rather constant for different invariant masses, there is an enhancement in the pK⁻$p{K}^{-}$ system towards lower masses which could at least be partially connected to the influence of the Λ(1405)$\Lambda (1405)$ resonance.