Asymmetric dihydroxylation of drim-7-en-11-ol: synthesis of diastereomerically pure driman-7α,8α,11-triol and its elaboration into novel chlorinated norlabdanic compounds

The asymmetric dihydroxylation of drim-7-en-11-ol was studied in detail and diastereomerically pure driman-7α,8α,11- and driman-7β,8β,11-triols were prepared. Further elaboration of driman-7α,8α,11-triol afforded 14,15-bisnorlabd-7α,8α-isopropylidenedioxy-11,13-dione from which a novel chlorinated bisnorlabdanic compound (14,15-bisnorlabd-12-ene-12-chloro-8α,13-epoxy-7α-ol-11-one) and an unusual dichloro-derivative, 13,14,15,16-tetranorlabd-12-dichloro-7α-acetoxy-8α-ol-11-one, were obtained.     

What Should I Notice? Using Algorithmic Information Theory to Evaluate the Memorability of Events in Smart Homes

With the increasing number of connected devices, complex systems such as smart homes record a multitude of events of various types, magnitude and characteristics. Current systems struggle to identify which events can be considered more memorable than others. In contrast, humans are able to quickly categorize some events as being more “memorable” than others. They do so without relying on knowledge of the system’s inner working or large previous datasets. Having this ability would allow the system to: (i) identify and summarize a situation to the user by presenting only memorable events; (ii) suggest the most memorable events as possible hypotheses in an abductive inference process. Our proposal is to use Algorithmic Information Theory to define a “memorability” score by retrieving events using predicative filters. We use smart-home examples to illustrate how our theoretical approach can be implemented in practice.     

A maxwellian lower bound for solutions to the Boltzmann equation

We prove that the solution of the spatially homogeneous Boltzmann equation is bounded pointwise from below by a Maxwellian, i.e. a function of the formc ₁ exp(-c ₂ v ²). This holds for any initial data with bounded mass, energy and entropy, and for any positive timet≧t ₀. The constantsc ₁, andc ₂, depend on the mass, energy and entropy of the initial data, and ont ₀>0 only. A similar result is obtained for the Kac caricature of the Boltzmann equation, where the proof is easier.     

Confronto di maggiorazioni funzionali

Summary In this work we continue the study of functional inequality already started in [BA1];we study some properties of this condition, especially the connections between functional inequalities with respect to different functional classes and the connections between couples of functions verifying a condition of functional inequality.     

Asymptotic Properties of the Inelastic Kac Model

We discuss the asymptotic behavior of certain models of dissipative systems obtained from a suitable modification of Kac caricature of a Maxwellian gas. It is shown that global equilibria different from concentration are possible if the energy is not finite. These equilibria are distributed like stable laws, and attract initial densities which belong to the normal domain of attraction. If the initial density is assumed of finite energy, with higher moments bounded, it is shown that the solution converges for large-time to a profile with power law tails. These tails are heavily dependent of the collision rule.     

Regenerative chemical biology: current challenges and future potential

The enthusiasm surrounding the clinical potential of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) is tempered by the fact that key issues regarding their safety, efficacy, and long-term benefits have thus far been suboptimal. Small molecules can potentially relieve these problems at major junctions of stem cell biology and regenerative therapy. In this review we will introduce recent advances in these important areas and the first generation of small molecules used in the regenerative context. Current chemical biology studies will provide the archetype for future interdisciplinary collaborations and improve clinical benefits of cell-based therapies.     

1H, 13C and 15N NMR spectral assignments of adenosine derivatives with different amino substituents at C6-position

The complete (1)H, (13)C and (15)N NMR signals assignment of adenosine derivatives differently substituted at C(6)-position was achieved using one- and two-dimensional experiments (gs-COSY, gs-NOESY, gs-HSQC and gs-HMBC).