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161.
    
It is known that phenylboronic acid (PBA) can target tumor tissues by binding to sialic acid, a substrate overexpressed by cancer cells. This capability has previously been explored in the design of targeting diagnostic probes such as Gd- and 68Ga-DOTA-EN-PBA, two contrast agents for magnetic resonance imaging (MRI) and positron emission tomography (PET), respectively, whose potential has already been demonstrated through in vivo experiments. In addition to its high resolution, the intrinsic low sensitivity of MRI stimulates the search for more effective contrast agents, which, in the case of small-molecular probes, basically narrows down to either increased tumbling time of the entire molecule or elevated local concentration of the paramagnetic ions, both strategies resulting in enhanced relaxivity, and consequently, a higher MRI contrast. The latter strategy can be achieved by the design of multimeric GdIII complexes. Based on the monomeric PBA-containing probes described recently, herein, we report the synthesis and characterization of the dimeric analogues (GdIII-DOTA-EN)2-PBA and (GdIII-DOTA-EN)2F2PBA. The presence of two Gd ions in one molecule clearly contributes to the improved biological performance, as demonstrated by the relaxometric study and cell-binding investigations.  相似文献   
162.
    
Smart PVCL-based nanogels for photosensitizers were prepared following the thermo precipitation methodology. PVCL-based imprinted and non-imprinted NGs are reported with different percentages of N,N′-methylenebisacrylamide (BIS) as crosslinker agent. Zn(II)phthalocyanine (ZnPc) is employed as a model photosensitizer and incorporated as a template molecule for imprinted NGs or it loads post-synthesis for non-imprinted NGs. In order to analyze the chemical structure, NGs were characterized using infrared microscopy. Hydrodynamic diameter was determined by dynamic light scattering. The phase transition temperature was measured by UV–vis spectroscopy. The phase transition temperature and Dh values were regulated by the percentage of crosslinker and the presence of the photosensitizer as a template or post-synthesis load. In all cases, the yields were acceptable and the smart nanodevices were stable.  相似文献   
163.
    
The effect of the annealing few degrees above the glass transition temperature (Tda = 62 °C) on the physical aging (Tpa = 51 °C) of amorphous quenched poly(l ‐lactide) is investigated by an implementation of variable temperature Fourier transform infrared (FTIR). By using a temperature program composed of a linear heating ramp superimposed to a temperature modulation (modulated temperature FTIR), the reversing and nonreversing intensity variation of selected bands, related to high‐energy gg and low‐energy gt conformers, is investigated. It is observed that the annealing above T g changes irreversibly the conformation distribution of the liquid polymer. The glasses obtained from annealed and nonannealed liquids behave differently, evolving in the physical aging toward their own liquid state and retaining the memory of their original condition before the vitrification. The recovery through T g of the relaxation occurred in the physical aging depends not only from aging conditions but also by the thermal history of the sample above the Tg. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019 , 57, 174–181  相似文献   
164.
We give several sets of parton densities derived from recent measurements of structure functions in deep inelastic scattering. The difference among these densities reflects the uncertainties from deep inelastic data of different experiments, allowing an estimate of the error band for the predictions one may obtain for any given hadronic process at higher energy. The densities are available at any scaleQ 2≦5.109 GeV2 andx≧5.10?5 and include next-to-leading corrections as well as threshold effects due to heavy flavours. A comparison with a large set of data in a wide range of scales (Drell-Yan,W andZ production, etc.) is also presented.  相似文献   
165.
In questa nota si affronta il problema della risoluzione di equazioni matriciali del tipoAX=B, doveA eB sono matrici a valori su un reticolo distributivo residuato rispetto a una moltiplicazione. In particolare, si individua la più grande soluzione di una tale equazione e si danno condizioni relative alle soluzioni minimali.  相似文献   
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The basic theory underlying the realization of simple multiple-band non-homogeneous dielectric resonators, whose spectral response is the overlap of single-resonator frequency bands, is developed exploiting a general approach discussed in the previous companion paper. The limit frequencies of the proposed devices, given only by the dielectric properties of the involved materials, can differ in principle by several decades. Experimental confirmations have been obtained on a composite structure built up with teflon and polyethylene; as predicted by the theory, the overall band includes frequencies which range about from 20 GHz to more than 400 GHz, when high frequency resonances are selectively excited. The localization of the higher frequency radiation between the positive steps of the dielectric constant, which is the basic properties of these non-homogeneous resonators, has been experimentally verified by mapping the electromagnetic field intensity. Possible applications of multiple-band Whispering Gallery dielectric resonators are finally outlined.  相似文献   
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We have computed the proton and neutron magnetic moments on the lattice by a Monte Carlo simulation of QCD in the quenched approximation. The results are in remarkable agreement with the experimental values.  相似文献   
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