Synthesis of 4-oxopyrimidinium and 4-oxo-1,4-dihydropyrimidines

The synthesis of N¹-substituted 4-pyrimidones is described. These compounds were prepared from their corresponding 4-oxopyrimidinium perchlorates or from a reaction of a primary amine with a N-acyl-β-ketoamide.     

The synthesis of some 2,4-disubstituted derivatives of quinolone-3-carboxylic acids and carbonitriles

In order to prepare the 2-chloro derivative of oxolinic acid, ethyl 1-ethyl-1,4-dihydro-2-hydroxy-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylate was treated with phosphorus oxychloride. The compound obtained was the 4-chloro-2-oxo-quinoline. The structure was confirmed by ¹³C nmr and mass spectral techniques. The 2-halocarbonitrile was obtained by a Sandmeyer reaction but could not be hydrolysed into the acid.