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71.
The utility of both 3‐(1‐benzotriazolyl) chalcone derivatives 3a‐c and 2‐(1‐benzotriazolyl)‐1,4‐pentadien‐3‐one (18) in the synthesis of some new 2‐(1H)‐pyridone, pyridine, pyrazole and isoxazole derivatives is reported. Antimicrobial and antifungal screening of some selected examples from the synthesized products were carried out. The structure of the newly synthesized compounds was elucidated by elemental analysis, ir, 1H and 13C nmr investigations. 相似文献
72.
The uptake behavior of porous silica modified with N‐propylsalicylaldimine (IE11) for Cd(II), Cr(III), Cu(II), Mn(II) and Pb(II) metal ions were studied. The Log kd values were found to be within the range 2.19–5.16 depending on pH and time of stirring. IE11 was used in the separation and preconcentration of Cd(II), Cr(III), Cu(II), Mn(II) and Pb(II) from some natural water samples. The data were compared with those obtained by the solvent extraction method (APDC/MIBK). The method was found to be accurate and precise and not subject to random error. 相似文献
73.
Fatima Al‐Omran Osama Yousef Abd El‐Hay Adel Abou El‐Khair 《Journal of heterocyclic chemistry》2000,37(6):1617-1622
A new approach to the synthesis of pyridazinone, ethoxypyridine, pyrazole and 7‐aminopyrazolo‐[1,5‐a]pyrimidine derivatives. The structure of the newly synthesized compounds was elucidated by elemental analyses, ir, 1H nmr spectra and in some cases by 13C nmr investigations. 相似文献
74.
The benzo[a]heptalene formation from 4‐[(R‐sulfonyl)acetyl]heptalene‐5‐carboxylates 15 and 5‐[(R‐sulfonyl)acetyl]heptalene‐4‐carboxylates 16 (R=Ph or morpholino) in the presence of R′SO2CH2Li and BuLi has been investigated (Scheme 6). Only the sulfonyl moiety linked to the C?O group at C(4) of the heptalene skeleton is found at C(3) of the formed benzo[a]heptalene‐2,4‐diols 3 in accordance with the general mechanism of their formation (Scheme 3). Intermediates that might rearrange to corresponding 2‐sulfonylbenzo[a]heptalene‐1,3‐diols lose HO? under the reaction conditions to yield the corresponding cyclopenta[d]heptalenones of type 11 (Schemes 6 and 7). However, the presence of an additional Me group at C(α) of the lithioalkyl sulfones suppresses the loss of HO?, and 4‐methyl‐2‐sulfonylbenzo[a]heptalene‐1,3‐diols of type 4c have been isolated and characterized for the first time (Schemes 8 and 10). A number of X‐ray crystal‐structure analyses of starting materials and of the new benzo[a]heptalenes have been performed. Finally, benzo[a]heptalene 4c has been transformed into its 1,2,3‐trimethoxy derivative 23 , a benzo[a]heptalene with the colchicinoid substitution pattern at ring A (Scheme 11). 相似文献
75.
Nabila A. Mazied Sahar A. Ismail Manal F. Abou Taleb 《Radiation Physics and Chemistry》2009,78(11):899-905
The use of hydrogels as carriers for anticancer delivery has been a subject of significant recent research. In our recent work, we have shown that diffusion-controlled delivery of flutamide from hydrogels containing poly (dimethylaminoethyl methacrylate (DMAEMA)/ethyleneglycol dimethacrylate (EGDMA)) can be possible and controlled by the three-dimensional structure. Hydrogels based essentially on dimethylaminoethyl methacrylate and different ratios of ethyleneglycol dimethacrylate monomers were synthesized using gamma radiation copolymerization. The influence of copolymer composition and pH value of the surrounding medium on swelling behavior into the glassy polymer were discussed. The results showed that the ratio of EGDMA in the comonomer feeding solution has a great effect on the gel fraction and water content in the final hydrogel. In this regard, it was observed that the increase of EGDMA ratio decreased these properties. The ability of the prepared copolymer to be used as drug carrier for anticancer drug-delivery system was estimated using flutamide as a model drug. In vitro drug-release studies in different buffer solutions show that the basic parameters affecting the drug release behavior of hydrogel are the pH of the solution and DMAEMA content of hydrogel. 相似文献
76.
Knoevenagel condensation of 2-(benzothiazol-2-ylthio) acetonitrile (2) with either furan-2-carbaldehyde or thiophene-2-carbaldehydes leads to E-isomers 4a-b exclusively, while the condensation of the compound 2 with benzaldehyde or para-substituted benzaldehydes with an electron-donating group afforded E/Z mixtures 4c-e with preferentially formation of the E-isomer. Condensation of furan-2-carbaldehyde (3a) with either 1-(benzothiazol-2'-ylthio) propan-2-one (5) or 2-(2'-oxo propylthio)-3-phenyl-quinazolin-4(3H)-one (9) leads exclusively to the Z-isomers of 6 and 10, respectively. The structures of the newly synthesized compounds were elucidated by elemental analyses, 1H-NMR and 13C-NMR spectra, COSY, HSQC, HMBC, NOE, MS and X-ray crystallographic investigations. 相似文献
77.
Faten I. Abou El Fadl 《Russian Journal of Applied Chemistry》2016,89(10):1673-1680
A novel hydrogel based on chitosan–poly(acrylamide-co-acrylic acid) (CAA) with different formulations were synthesized by the effect of gamma radiation. The magnetic CAA hydrogels were also synthesized and characterized by using different techniques, e.g., TEM and XRD. The prepared hydrogels and magnetic hydrogel nanocomposite were utilized for in situ cobalt nanoparticle preparation and employed as a reaction media in catalytic reduction of 2-nitrophenol (2-NP), to 2-aminophenol (2-AP). The experimental parameters that affect the reduction rates such as temperature and amount of catalyst were also, investigated. 相似文献
78.
Alaa A. Hassan Aboul‐Fetouh E. Mourad Kamal M. El‐Shaieb Ashraf H. Abou‐Zied 《Journal of heterocyclic chemistry》2006,43(2):471-475
Reactions of N,N′‐disubstituted hydrazine‐1,2‐carbothioamides 8a‐c and substituted N,N″‐ethane‐1,2‐diylbis(thioureas) 9a‐c with 2,3,5,6‐tetrachloro‐1,4‐benzoquinone (chloranil, 10a ) and 2,3,5,6‐tetrabromo‐1,4‐benzoquinone (bromanil, 10b ) to form N,N′‐disubstituted 1,3,4‐thiadiazole‐2,5‐diamines 11a‐c , substituted 3‐amino‐6,7‐dichloro‐2,3‐dihydro‐1H‐4,2,1‐benzothiadiazine‐5,8‐diones 12a‐c , 2,3,7,8‐tetrahalothianthrene‐1,4,6,9‐tetrones 13a,b , substituted 5,6,8‐trihalo‐7‐oxo‐3,7‐dihydroquinoxaline‐2H‐carbothioamides 14a‐c, 15a‐c and 7‐substituted imino‐1,3,6‐thiadiazepane‐2‐thiones 16a‐c are reported. 相似文献
79.
Mustafa alayan Alessandra Lucini Paioni Edy Abou‐Hamad Genrikh Shterk Alexey Pustovarenko Marc Baldus Abhishek Dutta Chowdhury Jorge Gascon 《Angewandte Chemie (International ed. in English)》2020,59(38):16741-16746
Methane dehydroaromatization (MDA) is among the most challenging processes in catalysis science owing to the inherent harsh reaction conditions and fast catalyst deactivation. To improve this process, understanding the mechanism of the initial C?C bond formation is essential. However, consensus about the actual reaction mechanism is still to be achieved. In this work, using advanced magic‐angle spinning (MAS) solid‐state NMR spectroscopy, we study in detail the early stages of the reaction over a well‐dispersed Mo/H‐ZSM‐5 catalyst. Simultaneous detection of acetylene (i.e., presumably the direct C?C bond‐forming product from methane), methylidene, allenes, acetal, and surface‐formate species, along with the typical olefinic/aromatic species, allow us to conclude the existence of at least two independent C?H activation pathways. Moreover, this study emphasizes the significance of mobility‐dependent host–guest chemistry between an inorganic zeolite and its trapped organic species during heterogeneous catalysis. 相似文献
80.
Alaa S. Abd‐El‐Aziz Amani A. Abdelghani Ebtehal G. El‐Ghezlani Doaa Abou El‐ezz Laila H. Abdel‐Rahman 《Macromolecular bioscience》2021,21(1)
The synthesis of a novel and attractive class of nonsteroidal anti‐inflammatory and antimicrobial organoiron dendrimers attached to the well‐known drug ibuprofen is achieved. The structures of these dendrimers are established by spectroscopic and analytical techniques. The antimicrobial activity of these dendrimers is investigated and tested against five human pathogenic Gram‐positive and Gram‐negative bacteria, and minimum inhibitory concentrations are reported. Some of these synthesized dendrimers exhibit higher inhibitory activity against methicillin‐resistant Staphylococcus aureus, vancomycin‐resistant Enterococcus faecium, and Staphylococcus warneri compare to the reference drugs. As well, the in vitro and in vivo anti‐inflammatory activities of these dendrimers are evaluated. The results of in vivo anti‐inflammatory activity and histopathology of inflamed paws show that all dendrimers display considerable anti‐inflammatory activity; however, second‐generation dendrimer ( G2‐D6 ) shows the best anti‐inflammatory activity, which is more potent than the commercial drug ibuprofen at the same tested dose. Results of the toxicity study reveal that G2‐D6 is the safest drug on biological tissues. 相似文献