Synthesis and Investigation of Derivatives of 1,8-Naphthalimide with a Red Emission via an Aromatic Nucleophilic Substitution Reaction

1,8-Napthalimides (NIs) have been widely used as fluorescent molecules in biological, chemical, and medical fields because NIs shows high stability and various fluorescence properties under different conditions. However, NIs typically display a fluorescence emission wavelength in the range of 350 – 550 nm which can be notably interfered with by autofluorescence in living cells, significantly limiting their bio-applications. Moreover, low solubility in aqueous media is another major limitation for NIs. In this project, four derivatives of NIs (1–4) have been synthesized via an aromatic nucleophilic substitution reaction and their photophysical properties have been investigated in various media (water, MeOH, MeCN, DMSO, EtOAc, and THF). All of these derivatives (1–4) show a long emission wavelength around 600 nm and high solubility in polar solvents. Particularly molecules (1–4) show the longest emission (624–629 nm) in water and the fluorescence intensity is not significantly varied in the range of pH 4–11. These unique features, long emission wavelength, high solubility, and high stability in difference pH media, will allow these derivative (1–4) to be used as excellent labeling reagents in the biological system.

     

Targeting the cytochrome bc1 complex for drug development in M. tuberculosis: review

Molecular Diversity - The terminal oxidases of the oxidative phosphorylation pathway play a significant role in the survival and growth of M. tuberculosis, targeting these components lead to...     

Evaluation of the magnetic moments of radium isotopes

Using the relativistic linked cluster many-body perturbation procedure we have obtained the hyperfine field at the nucleus of the Ra⁺ ion in the²S_1/2 ground state. There is good agreement between the calculated magnetic moment of²¹³Ra and the results of a recent Zeeman measurement by the collinear laser beam technique. Detailed comparison is carried out between our result and earlier ones.     

Performance improvement of spectral amplitude coding-optical code division multiple access systems using NAND detection with enhanced double weight code

The bit-error rate (BER) performance of the spectral amplitude coding-optical code division multiple access (SACOCDMA) system has been investigated by using NAND subtraction detection technique with enhanced double weight (EDW) code. The EDW code is the enhanced version of double weight (DW) code family where the code weight is any odd number and greater than one with ideal cross-correlation. In order to evaluate the performance of the system, we used mathematical analysis extensively along with the simulation experiment. The evaluation results obtained using the NAND subtraction detection technique was compared with those obtained using the complementary detection technique for the same number of active users. The comparison results revealed that the BER performance of the system using NAND subtraction detection technique has greatly been improved as compared to the complementary technique.     

Characterization of small-signal intensity modulation of single-mode fiber grating Fabry-Perot laser source

A comprehensive study on the small-signal intensity modulation (IM) characteristics of a fiber grating Fabry-Perot (FGFP) laser is numerically investigated. The effect of external optical feedback (OFB), temperature, injection current, cavity volume, nonlinear gain compression factor, and fiber grating (FG) parameters on IM characteristics are presented. The temperature dependence (TD) of IM is calculated according to the TD of laser cavity parameters instead of using the well-known Parkove relationship. It has been shown that the optimum external fiber length (L _ext) is 3.1 cm. The optimum range of working temperature for FGFP laser is between 23 to 27 °C. We also show that by increasing the laser injection current from 10 to 60 mA, the IM peak amplitude decreased from 6.3 to 0.2 dB and the relaxation-oscillation frequency (ROF) is shifted from 1.2 GHz towards higher frequency of 5.48 GHz. In addition, the AR coating reflectivity and gain compression factor have no significant effect on the IM. The study indicates that a stable operation and excellent modulation characteristic can be obtained after optimization process.     

Theoretical studies of structural and magnetic properties of cubic perovskites PrCoO3 and NdCoO3

The structural and magnetic properties of cubic perovskites, PrCoO₃ and NdCoO₃, are studied using the full potential linearized augmented plane wave (FP-LAPW) method within the frame work of density functional theory (DFT). The structural parameters are also investigated by analytical techniques. The calculated structural parameters are consistent with the experimental results. The strong hybridization of the O-2p, Co-3d and Pr/Nd-4 f states around the Fermi level reveals that these compounds are metallic. It is also found that the origin of ferromagnetism in these compounds is double-exchange interaction between Co-3d states via O-2p states (Co-O-Co).     

Search for a standard model Higgs boson in the H→ZZ→ℓ(+)ℓ(-)νν decay channel with the ATLAS detector

A search for a heavy standard model Higgs boson decaying via H→ZZ→→?(+)?(-)νν, where ?=e, μ, is presented. It is based on proton-proton collision data at √s=7 TeV, collected by the ATLAS experiment at the LHC in the first half of 2011 and corresponding to an integrated luminosity of 1.04 fb(-1). The data are compared to the expected standard model backgrounds. The data and the background expectations are found to be in agreement and upper limits are placed on the Higgs boson production cross section over the entire mass window considered; in particular, the production of a standard model Higgs boson is excluded in the region 340相似文献