全文获取类型
收费全文 | 3796篇 |
免费 | 113篇 |
国内免费 | 29篇 |
专业分类
化学 | 2290篇 |
晶体学 | 12篇 |
力学 | 98篇 |
数学 | 594篇 |
物理学 | 944篇 |
出版年
2021年 | 35篇 |
2020年 | 41篇 |
2019年 | 61篇 |
2018年 | 44篇 |
2017年 | 38篇 |
2016年 | 63篇 |
2015年 | 68篇 |
2014年 | 86篇 |
2013年 | 155篇 |
2012年 | 221篇 |
2011年 | 282篇 |
2010年 | 110篇 |
2009年 | 75篇 |
2008年 | 212篇 |
2007年 | 221篇 |
2006年 | 218篇 |
2005年 | 192篇 |
2004年 | 149篇 |
2003年 | 135篇 |
2002年 | 101篇 |
2001年 | 54篇 |
2000年 | 63篇 |
1999年 | 40篇 |
1998年 | 40篇 |
1997年 | 44篇 |
1996年 | 44篇 |
1995年 | 39篇 |
1994年 | 36篇 |
1993年 | 65篇 |
1992年 | 45篇 |
1991年 | 43篇 |
1990年 | 30篇 |
1989年 | 42篇 |
1988年 | 35篇 |
1987年 | 50篇 |
1986年 | 33篇 |
1985年 | 47篇 |
1984年 | 44篇 |
1983年 | 33篇 |
1982年 | 41篇 |
1981年 | 48篇 |
1980年 | 27篇 |
1979年 | 39篇 |
1978年 | 47篇 |
1977年 | 31篇 |
1976年 | 36篇 |
1975年 | 43篇 |
1974年 | 52篇 |
1973年 | 41篇 |
1972年 | 24篇 |
排序方式: 共有3938条查询结果,搜索用时 140 毫秒
941.
[formula: see text] The first enantioselective total synthesis of a batzelladine alkaloid is described. The central reaction in the synthesis of (-)-batzelladine D (2) is a tethered Biginelli condensation of a guanidine aldehyde and an acetoacetic ester to generate a 7-substituted-1-iminohexahydropyrrolo-[1,2-c]pyrimidine intermediate having the anti stereochemistry of the methine hydrogens flanking the pyrrolidine nitrogen. 相似文献
942.
The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways. 相似文献
943.
S-Adenosylmethionine (AdoMet) is a commonly used cofactor, second only to ATP in the variety of reactions in which it participates. It is the methyl donor in the majority of methyl transfer reactions, including methylation of DNA, RNA, proteins and small molecules. Almost all structurally characterised methyltransferases share a conserved AdoMet-dependent methyltransferase fold, in which AdoMet is bound in the same orientation. Although potential interactions between the cofactor and methyltransferases have been inferred from crystal structures, there has not been a systematic study of the contributions of each functional group to binding. To explore the binding interaction we synthesised a series of seven analogues of the methyltransferase inhibitor S-adenosylhomocysteine (AdoHcy), each containing a single modification, and tested them for the ability to inhibit methylation by HhaI and HaeIII DNA methyltransferase. Comparison of the Ki values highlights the structural determinants for cofactor binding, and indicates which nucleoside and amino acid functional groups contribute significantly to AdoMet binding. An understanding of the binding of AdoHyc to methyltransferases will greatly assist the design of AdoMet inhibitors. 相似文献
944.
The electrical double layer on gold probed by electrokinetic and surface force measurements 总被引:1,自引:0,他引:1
Gold surfaces, obtained by vacuum deposition of 15-nm gold films on glass and silica wafers, were studied in aqueous solutions by streaming potential measurements and colloidal-probe AFM force measurements. In the force measurements both a bare and a gold-coated silica particle (6 microm in diameter) have been used as colloidal probes. From the streaming potential measurements we determined the zeta-potential of the gold surface, while from the force measurements the diffuse double-layer potential psi(d) was obtained by fitting the data to the DLVO theory or to the nonlinear Poisson-Boltzmann equation. Measured interactions were found to be entirely due to overlap of electric double layers with no indication of attractive Van der Waals forces. Results of both types of measurements are in good agreement. The double layer potential strongly depends on the pH, probably as a result of the presence of oxide species on the gold surface. Insight in the double layer potential of polarizable interfaces such as the gold/electrolyte solution interface is the first step for understanding the effect of externally applied potentials on the adsorption behavior of charged species. 相似文献
945.
Ostwald Cohen Kohlrausch Heydweiller van't Hoff A. Naumann A. Rücker Arrhenius Walker Shields J. Walker E. Aston C. Kullgren Bredig Fraenkel W. E. Pawloff D. G. Gerassimoff Seth E. Moody R. W. Wood Will Koelichen M. Le Blanc K. Novotny Gernez H. Goldschmidt O. Girard Hantzsch Sebald G. Wiedemann B. E. Moore Dibbits W. Müller A. Birnbaum 《Analytical and bioanalytical chemistry》1907,46(2-3):159-165
946.
947.
948.
949.
950.