Possibility of intramolecular hydrogen bonding in 1-[β-(2-pyridyl)ethyl]-5-amino(or hydroxy) pyrazoles

It is shown on the basis of IR spectral and dipole moment data that the formation of a seven-membered cyclic structure is possible in 1-[-(2-pyridyl)ethyl]-5-amino(or hydroxy)-pyrazoles, stabilized by intramolecular hydrogen bonds.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1255–1257, September, 1970.     

Nitrogen-tellurium heterocycles

Several 2-substituted benzotellurazoles have been prepared by the reaction of N-allyl derivatives of o-methyltelluroaniline with POC1₃ or SOC1₂ followed by reduction of the -telluranes which are formed. The use of the zinc and sodium salts of o-aminotellurophenol and 2-chlorotellurenylazobenzene, in a procedure similar to that used to prepare benzothiazoles and benzoselenazoles, did not lead to the formation of benzotellurazoles.For Communication 1, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 120–125, January, 1989.     

Nitrogen-containing bisheterocyclic systems

A method has been developed for the synthesis of the previously undescribed hydroxy- and amino-1-benzazolyl-2-pyrazoles. Examination of the IR spectra and determination of the dipole moments has shown that these derivatives exist in the crystalline form and in solution as the hydroxy and amino forms, which are stabilized by intramolecular hydrogen bonding.For part III, see [12]Translated from Khimiya Geterotsiklicheskikh Soedinenii, Vol. 6, No. 5, pp. 660–663, May, 1970.     

Complexing properties of ambidentate benzo-15-crown-5-substituted azomethine ligands

Crown-containing azomethines and their zinc complexes were prepared. Examination of their structure by ¹H and ⁷Li NMR and electronic spectroscopy showed that, in accordance with the concept of hard and soft acids and bases, the hard lithium cation coordinates to the crown ether fragment with the formation of mono-(Li) and binuclear (Li, Zn) complexes.     

An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector

Background  

This study compared the transduction efficiencies of an adeno-associated viral (AAV) vector, which was pseudotyped with an AAV1 capsid and encoded the green fluorescent protein (GFP), with a lentiviral (LV) vector, which was pseudotyped with a VSV-G envelop and encoded the discosoma red fluorescent protein (dsRed), to investigate which viral vector transduced the lateral hypothalamus or the amygdala more efficiently. The LV-dsRed and AAV1-GFP vector were mixed and injected into the lateral hypothalamus or into the amygdala of adult rats. The titers that were injected were 1 × 10⁸ or 1 × 10⁹ genomic copies of AAV1-GFP and 1 × 10⁵ transducing units of LV-dsRed.     

Metal complexes with azomethines containing the isomeric <Emphasis Type="Italic">E-Z</Emphasis> azo fragments

Cobalt and zinc complexes with phenylazosalicylaldehyde azomethines were obtained by chemical and electrochemical syntheses. The B3LYP/6-311G(d, p) calculations showed that the azo group in both the ligands and the complexes are mainly in the E-form.     

Zn complex with N-(4′-Benzo-15-crown-5)-2-(amino-N-tosyl)-phenylaldimine: Synthesis, crystal structure, and vibration spectrum

The ZnL₂ complex (I) (HL = N-(4′-benzo-15-crown-5)-2-(amino-N-tosyl)phenylaldimine) is synthesized and studied by IR spectroscopy and X-ray diffraction analysis. The crystals are monoclinic: a = 23.139(2) Å, b = 19.931(2) Å, c = 14.604(2) Å, β = 121.20(1)°, Z = 4, space group C2/c, R = 0.751 for 766 reflections with I > 2σ(I). The Zn atom in a molecule of the complex lies on a twofold axis and is coordinated at the vertices of a distorted tetrahedron by four N atoms of two HL ligands (average Zn-N distance 2.024 Å).