Chemical instabilities during oxidation of 1,4-naphthalenediol in a homogeneous medium: II. Thermodynamic analysis and mathematical modeling

A possible mechanism of 1,4-naphthalenediol oxidation in the oscillatory regime has been considered, and a mathematical model describing the kinetics has been developed. Based on a thermodynamic Lyapunov function, it has been shown that the source of chemical instabilities is in the existence of autocatalytic steps and dynamic feedbacks. Qualitative analysis and numerical solution of the set of differential equations that model the reaction kinetics have been performed. The character of the stationary state and the possibility of bifurcations have been determined. The mathematical model satisfactorily describes the processes occurring in the system.     

Rhenium

Ohne Zusammenfassung     

New pi-extended water-soluble squaraines as singlet oxygen generators

[graph: see text] Condensation of squaric acid with a number of differently substituted 2-pyrrolyl derivatives afforded three new classes of squaraines. Their sharp and intense absorption bands in the biological window (700-900 nm), inherent singlet oxygen generation capabilities, together with proper functionalization allowing good water solubility make them suitable candidates as new non-porphyrinic singlet oxygen photosensitizers for photodynamic therapy (PDT).     

Protolytic reactions of 3,3'-dimethylnaphthidine and 3,3'-dimethoxybenzidine

The dissociation constants of diprotonated 3,3'-dimethylnaphthidine (DMN) and 3,3'-dimethoxybenzidine (DMB) have been determined spectrophotometrically. They are: pK(a1) = 2.62 +/- 0.03, pK(a2) = 3.33 +/- 0.09 for DMN: pK(a1) = 2.83 +/- 0.07, pK(a2) = 4.05 +/- 0.12 for DMB. The molar absorptivities (l.mole(-1).cm(-1)) of all forms of the indicators have been also determined: epsilon(B) = 1.68 x 10(4), epsilon(BH(+)) = 9.34 x 10(3), epsilon(BH(2+)(2)) = 1.80 x 10(3) at 300 nm for DMB; epsilon(B) = 7.33 x 10(3), epsilon(BH(+)) = 3.73 x 10(3), epsilon(BH(2+)(2)) = 0 at 330 nm for DMN.     

HYDROXYSTILBAZOLES AND HYDROXYAZAPHENANTHRENES: PHOTOCYCLIZATION AND FLUORESCENCE STUDIES

Abstract— As models for novel fluorescent probes, we have synthesized three isomeric hydroxystilbazole systems (4′-hydroxy-substituted 2-, 3-, and 4-stiIbazoles), examined their photocyclization-oxi-dation to four hydroxyazaphenanthrene systems, and made a preliminary study of their absorption and fluorescence spectra. All three stilbazoles can be prepared easily by addition of the isomeric picoline anions to 4-methoxybenzaldehyde, followed by dehydration and deprotection. Photocyclization proceeds efficiently, furnishing a single product isomer from each of the 2- and 4-stilbazole systems, and two isomeric azaphenanthrenes from the 3-stilbazole. The stilbazoles all have intense UV absorbance bands whose maxima depend upon solvent and pH; all three isomers have relatively similar spectra under neutral conditions and all three show a large red shift in base; in acid, however, the 2-and 4-stilbazole isomers show a greater red shift than the 3-stilbazole. The fluorescence of the stilbazoles is also solvent dependent, shifting to the red in more polar medium; red shifts are also observed in acid and base, but in acid, the 3-stilbazole shows a larger shift. The azaphenanthrene photocyclization products show absorbance spectra typical for quinolines and isoquinolines; their absorptivities are less than the stilbazoles, but their fluorescence is more intense. In general, the benzoquinolines have longer wavelength but weaker fluorescence than the benzoisoquinolines. Also, those isomers in which the resonance effects of the hydroxy and nitrogen groups can reinforce one another show longer wavelength emissions of greater intensity. All seven systems show dual fluorescence in water under neutral conditions, suggesting the emission from both non-ionized and ionized species in the excited state. In one case, the benzoisoquinoline system derived from 4′-hydroxy-4-stilbazole, an emission at 640 nm, observed in water over a wide pH range, is ascribed to a zwitterionic phototautomer. These stilbazoles, benzoquinolines and benzoisoquinolines may prove to be useful spectroscopic probes.     

Five-membered-ring-substituted 1-methyl-1H-indeno[1,2-b]pyridines

1-Methyl-1H-indeno[1,2-b]pyridine and 1-methyl-1H-5-(, -dicarbomethoxyvinyl)-(formyl, acetyl)indeno[3,2-b]pyridines were obtained by treatment of N-methyl-4-azafluorenium iodide, as well as mixtures of it with acetylenedicarboxylic ester, dimethylformamide (DMF), and phosphorus oxychloride or acetic anhydride, with bases. 4-Azafluoronenone was used to synthesize 9-(p-methoxyphenyl)-4-azafluoren-9-ol, which was reduced to 9-(p-methoxyphenyl)-4-azafluorene, and 1-methyl-1H-5-(p-methoxyphenyl)indeno[3,2-b]pyridine was obtained from the methiodide of the latter.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1382–1386, October, 1981.