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将N-氨基-4-N-甲基哌嗪-1,8-萘酰亚胺(AMN)通过酰胺化反应接枝到聚丙烯酸链上,利用生成的聚合物在水溶液中的自组装, 制备了一种水溶性荧光纳米粒子(PAAMN).采用紫外可见光谱、核磁共振氢谱、透射电镜、动态光散射和荧光光谱方法对PAAMN进行了表征,MTT法检测其细胞相容性,最后用荧光显微镜观察其自身荧光及细胞成像效果.实验结果表明, PAAMN为球状结构,萘酰亚胺荧光团的摩尔取代度为4.1%;在生理pH条件下,以390 nm为激发波长,PAAMN在534 nm处发射较强的荧光,且光稳定性较好;在pH 4.0~10.0范围内,其荧光波长无明显变化,荧光强度随pH值增大而逐渐减小,但pH敏感程度小于AMN.PAAMN具有良好的细胞相容性,能进入细胞,且在~390 nm激发光下发射绿色荧光,可用于细胞成像. 相似文献
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Macromolecular ligands with liver-targeting group (pyridoxamine, PM) PHEA-DTPA-PM and PAEA-DTPA-PM were prepared by the incorporation of different amount of diethylenetria-minepentaacetic acid monopyridoxamine group (DTPA-PM) into poly-cc, p-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) and poly-α, β-[N-(2-aminoethyl)-L-aspartamide] (PAEA). The macromolecular ligands thus obtained were further complexed with gadolinium chloride to give macromolecular MRI contrast agents with different Gd(Ⅲ) contents. These macromolecular ligands and their gadolinium complexes were characterized by 1H NMR, 1R, UV and elementary analysis. Relaxivity studies showed that these polyaspartamide gadolinium complexes possess higher relaxation effectiveness than that of the clinically used Gd-DTPA. Magnetic resonance imaging of the liver in rats and experimental data of biodistribution in mice indicate that these macromolecular MRI contrast agents containing pyridoxamine exhibit liver-targeting property. 相似文献
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Poly(9-phenyl-2,4,8,10-tetraoxaspiro-[5,5]undcane-3-one)(PPTC) was synthesized by the microwave-assisted ring-opening polymerization(MROP) of a six-membered cyclic carbonate monomer 9-phenyl-2,4,8,10-tetraoxaspiro-[5,5]undcane-3-one(PTC) with tin(Ⅱ) 2-ethylhexanoate(Sn(Oct)_2) or aluminum isopropoxide(Al(O~iPr)_3) as the catalysts. The obtained polycarbonates were further reduced by apalladium/carbonate catalyst(10% Pd/C) to afford partly deprotected polycarbonates containing hydroxyl groups(HPPTC). These two types of polycarbonates were characterized by ~1H-NMR, Fourier transform infrared spectroscopy(FTIR), UV, gel permeation chromatography(GPC), differential scanning calorimetry(DSC), and automatic contact-angle measurements. The influence of the feed molar ratio of monomer-to-catalyst, the microwave irradiation power and the reaction time on the polymerization was also studied. The experimental results showed that HPPTC possessed significantly higher hydrophilicity and water absorption rate than PPTC. 相似文献
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多氮杂环化合物及其衍生物近年来愈来愈显示出其重要而广泛的用途,譬如:可作为人体内结石的清除药物[‘·’j,作为MnSOD的模拟物可抑制心肌缺血性再灌注引起的损伤[’j,且具有抗爱滋病活性等;尤其是在制造磁共振成像(MRI)、X射线CT、超声成像等医学影像技术的造影剂以及恶性肿瘤的放射性治疗药物方面[‘-’‘,多氨杂环烷烃特别是1,4,7,10一四氮染环十二烷(Cyclen,环楞胺)及其衍生物显示出极其重要的应用价值.多氨杂环烷烃及其衍生物可因具体情况有不同的合成方法,环楞胺最初由乙二胶二乙酸氯与乙二胺在高度稀释条… 相似文献
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将具有肿瘤靶向性的磺胺嘧啶(SD)、二乙三胺五乙酸(DTPA)与葡聚糖(dextran)大分子侧链羟基偶联,合成葡聚糖大分子配体(SD-Dextran-DTPA),再与金属钆离子Gd3+配合,从而制备肿瘤靶向性葡聚糖大分子钆配合物(SD-Dextran-DTPA-Gd).对所合成的配体及钆配合物进行FTIR、UV和1H-NMR等结构表征,测试了配体及钆配合物在水溶液中的粒径分布和zeta电位、钆配合物的体外弛豫率、细胞摄取与T1加权磁共振成像性能.与小分子钆-二乙三胺五乙酸(Gd-DTPA)相比,SD-Dextran-DTPA-Gd具有较高的弛豫率,对肺癌细胞系H460、乳腺癌细胞系MDA-MB-231和T40D均有较好的亲和性,可被肿瘤细胞较好地摄取,并能获得较好的肿瘤细胞磁共振成像. 相似文献