7-羟基黄酮及磷酰化7-羟基黄酮与DNA的弱相互作用荧光法研究

以溴化乙锭(EB)为荧光探针,研究了7-羟基黄酮及磷酰化7-羟基黄酮与DNA的弱相互作用。实验结果表明,两种化合物与DNA间均存在弱相互作用,但与7-羟基黄酮相比,磷酰化7-羟基黄酮对DNA更具亲和力。随着温度的升高,7-羟基黄酮及磷酰化7-羟基黄酮对DNA-EB体系的荧光猝灭常数降低,两种化合物均可与DNA形成复合物,此猝灭过程为静态猝灭。根据Stern-Volmer方程和Scatchard方程,常温下7-羟基黄酮及磷酰化7-羟基黄酮对DNA-EB体系的荧光猝灭常数和它们与DNA的固有的结合常数分别为：K_q1=601 L·mol-1,K_q2=1 381 L·mol-1;K₁=2.07×104 L ·mol-1,K₂=3.19×104 L·mol-1。     

分光光度法研究钴(Ⅱ)-槲皮素配合物

利用分光光度法研究了槲皮素与Co（Ⅱ）形成配合物的最佳反应条件,测定了其配比和条件稳定常数。结果表明,在pH 4.7 HAc-NH₄Ac缓冲溶液中.槲皮素与Co（Ⅱ）配位,该配合物在584nm处有最大吸收。Co²⁺的浓度在2.0×10^-5—1.1×10^-4mol/L之间与吸光度呈线性关系。采用等摩尔连续变化法测得槲皮素-Co（Ⅱ）配合物的配位比为2:1,计算得到该配合物的条件稳定常数为2.7×10⁷L²·mol^-2。     

含吡嗪甲酸配体的双核铬配合物的水热合成、晶体结构及荧光性质

通过水热法合成了1个双核铬配合物[Cr2(OH)2(2-pca)4].3H2O(2-Hpca=2-吡嗪甲酸),并对其进行了X-射线单晶衍射、红外光谱、元素分析、荧光和热的表征及研究。该配合物属于单斜晶系,P21/c空间群。晶体学数据:a=1.566 35(15),b=0.847 70(6),c=1.974 60(18)nm,β=90.645 0(10)°,C20H20Cr2N8O13,Mr=684.44,V=2.621 7(4)nm3,Dc=1.734 g.cm-3,F(000)=1 392,μ=0.913 cm-1,Z=4,最终R=0.044 7,wR=0.112 0用于3 251个可观测点。在晶体结构中,每个铬原子均为六配位,其中来自两分子2-吡嗪甲酸的2个氮原子、2个羧酸基氧原子和2个桥连羟基上的氧原子,呈现畸变的八面体几何构型。     

水杨醛肟和乙酰氧肟酸钛氧簇合物的合成及光电性质

通过溶剂热合成方法,以水杨醛肟(H₂Saox)和乙酰氧肟酸(H₂Ahox)为染料敏化功能配体,分别以异丁酸(HiBuac)和苯基膦酸(PhPO₃H₂)为辅助配体,与钛酸四异丙酯(Ti (OⁱPr)₄)反应,合成了六核钛氧簇配合物[Ti₆(μ₃-O)₄(Saox)₂(ⁱBuac)₄(OⁱPr)₈](1)和八核钛氧簇配合物[Ti₈(μ₃-O)₂(Ahox)₂(PhPO₃)₄(OⁱPr)₁₆](2)。配合物1和2均通过红外光谱、元素分析和单晶X射线衍射进行了结构表征。光谱性质表明,配合物1和2在可见光区均有吸收,其带隙分别为2.43和2.61 eV。配合物2是首个基于乙酰氧肟酸的钛氧簇,具有光催化析氢性能且速率可达140.2 μmol·g^-1·h^-1。     

Solvothermal Synthesis,Crystal Structure and Photocurrent Property of a Ti_6-Core-based Titanium Oxo Cluster

A Ti₆-core-based titanium oxo cluster (TOC)[Ti₆(m₂-O)₂(m₃-O)₂(Bpo)₂(PhCOO)_8(Oi Pr)_4]assembled by 2,2'-biphenol (H₂Bpo) and benzoic acid has been synthesized and characterized by IR,elemental analyses,thermogravimetric analysis and X-ray diffraction technique.Single-crystal X-ray diffraction analysis revealed that the complex crystallizes in monoclinic system,space group P2₁/n.The structure contains two Ti₃(m₃-O) units featuring a flat mode as building blocks.Solid-state UV/Vis absorption spectrum reveals that complex 1 shows a wide range from 240 to 650 nm.Moreover,the optical band gap of 1 is estimated to be 2.35 eV.Additionally,the Ti_6-TOC exhibits good photocurrent response.     

1-[二-(4-氟苯)甲基]-4-酰基取代哌嗪类衍生物的合成

1-[二-(4-氟苯)甲基]-4-取代哌嗪是一类重要的药物中间体,随着哌嗪环4-位引入不同的取代基可以产生不同的生物活性,如治疗偏头痛药物氟桂利嗪、洛美利嗪,抗氧化剂、钙拮抗剂、癌症治疗中多种抗药性的调节剂(modulator of MDR)等;此外,含有酰基结构单元的哌嗪     

Hydrothermal Synthesis,Crystal Structure and Luminescence Property of a 2D Manganese(Ⅱ) Coordination Polymer

Solvothermal reactions of MnCl_2·4H_2O with(pyridin-2-yl)methyl 4-(2-(4-((pyridin-2-yl)methoxy)phenyl)diazenyl)benzoate(L1) via an in situ ligand transformation reaction produced a new coordination polymer, {[Mn_(2.5)Cl_3L_2(H_2O)]·H_2O}_n(1, where HL = 4-(2-(4-((pyridin-2-yl)methoxy)phenyl)diazenyl)benzoic acid). The L1 ligand was decomposed in situ to L~- which was coordinated with Mn(Ⅱ) to form compound 1 in the solvothermal synthesis process. Complex 1 was characterized by IR spectroscopy, powder X-ray diffraction and single-crystal X-ray diffraction.Compound 1 possesses a 2D network. In addition, stability and photoluminescent property of 1 were also investigated.     

N-茄呢基-N,N′-二(3,4-二甲氧基苄基)乙二胺的合成

癌症仍是需要攻克的医学难题之一. 虽然已有多种抗癌剂用于临床,但大多数抗癌剂是以细胞毒性来抑制癌细胞的繁殖,使用剂量受到限制,长期治疗还会产生毒副作用. 研究表明,N-茄呢基-N,N′-二(3,4-二甲氧基苄基)乙二胺(简称SDB-乙二胺)[1]具有优先作用于多种抗药性肿瘤的直接的细胞毒性,对几乎所有类型临床抗肿瘤药物具有增效作用,其中对抗生素类和生物碱类抗癌药物的增效尤为显著,如对其中的博莱霉素(争光霉素)、呱来霉素、磅霉素等,每毫升注射液含有3和10 μg的SDB-乙二胺,药效分别能提高47和130倍,对新制癌菌素(neocarzinostatin)也能提高2倍以上[2]. 与其他增效剂相比,SDB-乙二胺的增效作用具有定向细胞毒性,而本身完全没有细胞毒性,安全性好,可以连续使用,可减少抗癌剂的剂量,减轻毒副作用[3]. 因此,研究开发抗癌药物增效剂是癌症治疗的发展方向之一.     

Synthesis and Crystal Structure of a New [Mn_2Ni_2] Cubane Complex

A new Mn2Ni2 cubane complex has been synthesized and characterized by single-crystal X-ray diffraction,FT IR spectra and elemental analysis.The title compound [MnIII2NiII2(hmp)4(N3)4(O2CR)2](hmp-is the anion of 2-pyridinemethanol and O2CR-is α-na-phthaleneacetate)crystallizes in the monoclinic system,space group P21/c with a = 10.519(5),b = 22.109(10),c = 23.235(9),β = 106.096(17)o,C48H42Mn2N16Ni2O8,Mr = 1198.28,V = 5192(4)3,Dc = 1.533 g/cm3,F(000)= 2448,μ = 1.258 cm1,Z = 4,the final R = 0.0875 and wR = 0.2020 for 3398 reflections with I > 2σ(I).X-ray diffraction analysis reveals that each Mn(III)center is octahedrally coordinated by two nitrogen atoms of azide anions and three oxygen atoms from three 2-pyridinemethanol anion ligands together with one oxygen atom from naphthaleneacetate.Each Ni(II)is octahedrally coordinated by two nitrogen atoms of 2-pyridinemethanol anion ligands as well as three oxygen atoms from three 2-pyridinemethanol anion ligands and one oxygen atom from naphthaleneacetate.     

基于二乙醇胺配体的[Dy2Co8]型配合物的合成、晶体结构和磁性分析

以二乙醇胺为配体合成了一种具有[Dy₂Co₈]核结构的配合物[Dy₂Co₈（L）₄（HL）₄（HCOO）₄（OH）₂Cl₂（CH₃OH）₂]Cl₂·4CH₃OH·2H₂O（1）（H₂L=二乙醇胺）,并对其进行了X射线单晶衍射、红外光谱、元素分析和磁性表征。该配合物属于三斜晶系,P1空间群。晶体学数据：a=1.160 4（8）nm,b=1.322 7（9）nm,c=1.465 3（9）nm,α=71.181（7）°,β=67.638（7）°,γ=65.939（7）°。在晶体结构中,每一个Dy（Ⅲ）都是九配位,而每一个Co（Ⅱ）均为六配位。