二吡唑基甲酮类化合物的合成和表征

以5-氨基-3-甲硫基-1H-吡唑-4-羧酸乙酯(1)为原料, 依次经肼解、与取代的乙烯酮二硫缩醛缩合和烷基化合成了一系列二吡唑基甲酮类化合物, 经¹H NMR, ¹³C NMR和元素分析确证了它们的结构, 部分化合物进一步经过了质谱表征.     

苯萘基糖苷类化合物的合成及其治疗糖尿病的活性

以1,2-二甲氧基苯,丁二酸酐以及α-溴代四乙酰基吡喃糖为原料,设计并合成了作为SGLT2抑制剂的两个结构新颖的苯萘基糖苷化合物(6a和6b),其结构经1H NMR, 13C NMR, IR和ESI-MS确认.利用小鼠体内葡萄糖耐受量法测定了6治疗糖尿病的活性,结果发现6a具有明显的降血糖作用,其活性与阳性对照药格列齐特相当.     

含反式环己烷结构的C-葡萄糖苷类SGLT2抑制剂的设计、合成与降血糖活性研究

设计并合成了一系列含有反式环己烷结构的C-葡萄糖苷类SGLT2抑制剂,关键步骤是对溴苯甲醚与反式环己烷甲酰氯在无水AlCl3催化下的区域选择性Friedel-Crafts酰基化.所有化合物的结构经过了1H NMR和HRMS的表征.小鼠口服糖耐量实验(OGTT)显示,化合物11a～11d均显示较强的降血糖活性,且11c的活性超过了阳性对照药dapagliflozin,具有良好的开发前景.     

Synthesis and Crystal Structure of 7-Ethoxycarbonyl-2-methyl-6-methylthio-1H-imidazo[1,2-b]pyrazole

The title compound 7-ethoxycarbonyl-2-methyl-6-methylthio-lH-imidazo[1,2-b]- pyrazole （Mr = 239.29） was synthesized and structurally characterized by IR, ^1H NMR and single-crystal X-ray diffraction. It belongs to the triclinic system, space group P1, with a =8.0461（10）, b = 8.5534（11）, c = 9.5605（12）А,α= 64.804（2）,β= 74.231（2）, γ= 76.885（2）°, V = 568.27（12）А^3, Z = 2,Dc= 1.398 g/cm^3,μ= 0.274 nunl, F（000） - 252, the final R = 0.0454 and wR = 0.1261. A total of 3360 reflections were collected, of which 2466 were independent （R_int = 0.0138） and 2154 were observed with I〉2σ（I）.     

高Tc铜氧化物超导体的同位素效应与氧的含量、位置的关系

在本文中,讨论了高Tc铜氧化物超导体中的同位素效应指数αO.αCu与氧的含量,位置的关系,得出了同位素效应指数的变化与氧的含量,位置密切相关.     

Syntheses and molecular self-assembly of chiral phosphorami-dates

Two chiral phosphoramidates,(R)-(-)-1,1'-binaphthyl-2,2'-dihydroxy-N-[α-(S)-methylbenzyl] phosphoramidate and (-)-1,1'-biphenyl-2,2'-dihydroxy-N-[α-(S)-methylbenzyl]-phosphoramidate were synthesized.Their crystal structures were determined by X-ray single crystal diffraction analysis.The phosphoramidate molecules are self-associated by inter-molecular N-H...O = P hydrogen bonds and aromatic edge to face interactions.     

对甲氧基苯甲醛肟晶体结构、红外光谱及分子间相互作用的实验与理论研究

从实验和理论两个方面研究了Z型和E型对甲氧基苯甲醛肟晶体的熔点、 结构、 红外光谱和分子间相互作用. 在E型和Z型晶体中, 对甲氧基苯甲醛肟分子分别呈二聚体重复单元和双链Zigzag结构排列. 研究结果表明, 电荷分布变化引起的静电相互作用差别、 形成氢键的方式和强度以及晶体中分子排列方式导致的范德华作用不同是造成Z型和E型对甲氧基苯甲醛肟固体熔点、 红外光谱等物理性质差别的根本原因.     

肽脱甲酰化酶抑制剂的合成及其抑菌活性

通过对肽脱甲酰化酶抑制剂构效关系的研究,以放线酰胺素为先导化合物,设计并合成了一系列异噁唑类化合物。其结构经1H NMR,IR,MS和元素分析表征。生物活性实验表明,该类化合物对标准肺炎克雷白球菌有显著的抑菌活性。     

Synthesis and Crystal Structure of Ethyl 1-（2-bromoethyl）-3-（4-meth-oxyphenyl）-1H-pyrazole-5-carboxylate

The title compound ethyl 1-(2-bromoethyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate 1 has been synthesized and structurally characterized by single-crystal X-ray diffraction.The crystal is of monoclinic(C15H17BrN2O3,Mr = 353.22),space group C21 with a = 24.691(7),b = 6.7678(17),c = 17.884(5) ,β = 97.184(5)o,V = 2965.1(13) 3,Z = 8,Dc = 1.583 g.cm-3,F(000) = 1440,μ = 2.784 mm-1,the final R = 0.0260 and wR = 0.0596 for 2684 observed reflections with I > 2σ(I).All the carbon atoms in the molecule are nearly coplanar except C(15),with a large conjugated system among the carbonyl group,pyrazole ring and the benzene ring.Three non-classical intermolecular hydrogen bonds help to stabilize the crystal lattice.The regioselectivity was rationalized based on the coordination of potassium ion with the N-anion and the carbonyl oxygen atom.