手性铝试剂促进的β-环氧醇动力学拆分研究

首次以手性联萘酚修饰的三乙基铝为催化剂对消旋的β-环氧醇的动力学拆分进行了研究, 初步研究结果表明其回收原料的ee值可达60%. 同时研究了不同条件下三乙基铝与手性配体形成的手性路易斯酸对β-环氧醇的动力学拆分的影响, 并探讨了在三乙基铝催化下的反应机理.     

First Synthesis of （＋）-2,14-Deoxyalatol from α-Santonin

A novel and general approach for synthesis of the multi-oxygenated dihydrofuran sesquiterpenes has been developed starting from santonin. The key steps involve: the strategic acid-catalyzed double-bond shifting affording 4, the novel base-promoted epoxide rearrangement of 5 generating two key functionals (the C5-OH and the Δ^7,11 double bond), and the stereoselective cyclization of tetrahydrofuran ring without pre-controlling the stereochemistry of C-7. As an example of this approach, synthesis of ( )-2,14-deoxyalatol was described in detail.     

β-二氢沉香呋喃倍半萜的1H和13C化学位移全指定及13C化学位移与立体化学之间的关系

采用¹H,¹³C-COSY和COLOC谱,对三个(1-3)β-二氢沉香些喃倍半萜的¹H和¹³C化学位移进行了全指定.经过考察和比较上述化合物及十九个文献报导化合物的立体化学和C-14化学位移的关系,得出一个新的,非常重要的构型判断方法.