通用模拟退火用于稳健多元分析校正

模拟退火是一种全局优化算法，具有跨越局部最优点的机制，最小一乘是一种较常用的最小二乘更为稳健的优化准则，更适用于可能偏离正态分布的实际数据集，本文探讨了用最小一乘为准则并利用模拟退火方法同时测定多组分体系的可能性。应用于2－3组分药物体系分析，获得了满意的结果，本文还探讨了改变步长提高模拟退火算法优化精度的方法。     

An Improved Synthesis of Retinoic Acid from β-Ionone

A convenient and large-scale preparation of retinoic acid 1 from β-ionone in five steps with 38% overall yield is described.The key steps are the epoxidization of 2 with a new methylated agent and the condensation 4 with tetraethyl methylenediphophonate in one-pot procedure to prepare 6.     

农药甲霜林对映体的高效液相色谱分离及手性拆分热力学研究

以正己烷/异丙醇为流动相，在纤维素-三（3，5-二甲基苯基氨基甲酸酯）（CDMPC）涂敷型手性固定相上，对农药甲霜灵外消旋体进行了拆分，考察了流动相组成、柱温等对甲霜灵对映体的保留和分离的影响；对甲霜灵R、S对映体与固定相之间的保留和分离的热力学机理进行了讨论。     

Indriect Determination of CTMAB with Sodium Chloride and Ammonium Thiocyanate by Floatation and Separation of Zine

A new method for indirect determination of cetyl-trimethyl ammonium bromide (CTMAB) with NaCl and NH4SCH by floatation and separation of zinc has been studied.The study shows that Zn(Ⅱ） can associate with NH4SCN and CTMAB to form insoluble ternary ion-association complex,and the precipitate can float on the surface of the liquid phase.A good linear relationship is observed between the floatation yield(E%) of Zn(Ⅱ） and the amount of CTMAB.On the ground,CTMAB Can be indirectly determined by determining E% of Zn(Ⅱ）.The results were satisfactory.     

STUDIES ON THE SORPTION OF MACROPOROUS PHOSPHONIC ACID RESIN FOR LANTHANUM

The influences of Medium pH,sorption temperature,sorption time,etc.on the sorption capacity of macroporous phosphonic acid resin for La^3+ were determined.The sorption rate constant was k298=7.64×10^-5 s^-1. The complex ratio of phosphonic groups of the resin to La^3+ was 3:1.The basic sorption parameters were determined. The sorption mechanism of macroporous phosphonic acid resin for La^3+ was examined by chemical analysis and IR-spectrometry.