Computational design of proteins with novel structure and functions

Computational design of proteins is a relatively new field, where scientists search the enormous sequence space for sequences that can fold into desired structure and perform desired functions. With the computational approach, proteins can be designed, for example, as regulators of biological processes, novel enzymes, or as biotherapeutics. These approaches not only provide valuable information for understanding of sequence–structure–function relations in proteins, but also hold promise for applications to protein engineering and biomedical research. In this review, we briefly introduce the rationale for computational protein design, then summarize the recent progress in this field, including de novo protein design, enzyme design, and design of protein–protein interactions. Challenges and future prospects of this field are also discussed.     

药学专业药物化学实验教学现状与教学改革

从实验课与理论课相互关系、实验教学内容、与基础课的衔接、与相关课程的沟通和实验室管理等5个方面分析了药物化学实验教学中存在的问题,针对这些问题提出了改革措施,并对药学实验教学改革进行了展望。     

Calculation of Internal Energy and Pressure of Dense hydrogen Plasma by Direct Path Integral Monte Carlo Approach

The internal energy and pressure of dense hydrogen plasma are calculated by the direct path integral Monte Carlo approach. The Kelbg potential is used as interaction potentials both between electrons and between protons and electrons in the calculation. The complete formulae for internal energy and pressure in dense hydrogen plasma derived [or the simulation are presented. The correctness of the derived formulae are validated by the obtained simulation results. The numerical results are discussed in details.     

全息记录材料在太阳能利用方面的应用——全息太阳能集光器和全息窗

本文简要介绍了全息太阳能集光器和全息窗的原理、特性及应用前景。     

cis－［Pt（NH_3）_2Cl_2］和trans－［Pt（NH_3）_2Cl_2］的微型合成

ｃｉｓ－［Ｐｔ（ＮＨ_３）_２Ｃｌ_２］和ｔｒａｎｓ－［Ｐｔ（ＮＨ_３）_２Ｃｌ_２］的微型合成袁书玉，来月英（清华大学化学系，北京１０００８４）ｃｉｓ－［Ｐｔ（ＮＨ２）２Ｃｌ２］为一抗癌药物，而它的反式异构体却没有这一特性。其原因也已在进行研究［１］。由...     

引伸一道典型平几题

在教学中,立足于课本,对课本中的有些典型习题进行变形、引伸、拓广,通过一例解决一类,触类旁通,不仅有利于双基的落实,而且还可以培养学生分析问题解决问题的能力。试举一例说明。题目已知(如图1),点C为线段AB上一点,△ACM、△CBN是等边三角形,求证AN=BM。(《几何》第一册P153.10) 这是一道典型的几何题,要证AN=BM,只要     

关于用分段多项式逼近的逆定理的注记

Schumaker,L.L.在[1]中证明了下述定理:定理S_1设[a,b]的分划序列△_v满足混合条件,并且稳定地趋于0,那么     

RNA结构及预测的研究进展

综述了RNA的二级结构和三级结构特点以及RNA二级结构预测的研究进展。