4-(3-吲哚基)-3-丁烯-2-酮苯甲酰腙Schiff碱过渡金属配合物的合成、表征及生物活性研究

A Schiff base ligand 4-[indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML₂，M=Cu(Ⅱ), Ni(Ⅱ), Zn(Ⅱ) and Co(Ⅱ)) have been prepared and characterized by means of elemental analysis, EI-MS, molar conductivity, IR, UV-Vis and ¹H NMR. The results showed that HL as a bidentate ligand coordinated with transition metal ions to form four-coordination complexes. The antibacterial activity was studied by using the filter scraps diffusion method, and the results indicated that the ligand and the complexes had a low bacteriostatic activity against S. Aureu, P. Aeruginosa and E. Coli. The low in vitro antitumor activity of the title complexes was also observed by using MTT method against KB, A2780, Bel7402 and HELF.     

超声辐射下合成4,5-二氢-1-取代胺亚甲基-3-(2-三氟甲基苯并[d]咪唑- 1-亚甲基)-4-芳基-1,2,4-三唑-5-硫酮

以1-肼羰亚甲基-2-三氟甲基苯并[d]咪唑(1)为原料, 与芳基异硫氰酸酯在无水乙醇中反应得酰氨基硫脲2a～2d, 继而在氢氧化钠水溶液中合环得4,5-二氢-3-(2-三氟甲基苯并[d]咪唑-1-亚甲基)-4-芳基-1,2,4-三唑-5-硫酮(3a～3d), 然后分别采用超声辐射法和常规加热法与四种胺反应合成了16个未见报道的Mannich碱4a～4d, 5a～5d, 6a～6d和7a～7d. 与常规加热法对比, 超声辐射法具有操作简单, 反应时间短, 条件温和, 产率高, 副反应少等优点, 为此类化合物的合成提供了一种有效的新方法. 目标化合物的结构经元素分析, IR和¹H NMR确证.     

A New Nanogold-Labeled Immunoresonance Scattering Spectral Probe for Determination of Trace IgG

A kind of 9 nm gold nanoparticles was prepared with the trisodium citrate and used to label goat anti-human IgG to obtain an IgG immunoresonance scattering spectral probe. In pH 5.8 buffer solution and in the presence of polyethylene glycol （PEG）, the immune reaction between gold-labeled goat anti-human IgG and IgG took place, and the resonance scattering intensity at 580 nm （I580nm） was enhanced greatly. The enhanced intensity AIRS is pro- portional to the IgG concentration from 1.3 to 1.5 X 10^3 ng.mL^-1, with a detection limit of 0.78 ng.mL ^-1. This assay showed high sensitivity and good selectivity for quantitative determination of IgG in human serum, with satisfactory results.     

铅染毒大鼠骨中元素微区分布及相关性研究

北京同步辐射装置上的同步辐射X射线探针被用于测定铅染毒大鼠骨中铅和其它元素微区分布,结果发现: 铅主要分布在密质骨内、外边缘, 而锌主要分布在密质骨和密质骨边缘. 同时,钙、磷、锶和铁的分布也同时获得.     

自适应蚁群算法在双向生产车间调度中的应用

本文将蚁群算法与双向调度算法结合，用以解决以生产周期和关键工件交货期为优化目标的车间作业调度问题。在传统的蚁群算法的基础上自适应调整挥发系数ρ，采用新的启发式信息——机床利用率来定义能见度函数，ηij（t），采用了新的allowed表更新方式。最后通过仿真实验证实了本文的自适应蚁群算法在车间作业的双向调度中优于现在广泛采用的遗传算法。     

浅析液体压强实验

前段时间笔者到成都一所重点中学参观并与学生一起做了探索液体压强的相关实验,归纳了此组实验常出现的几个问题及解决办法,供大家参考.     

微软帮助系统的开发研究

介绍了微软帮助系统，以及它的发展，分析了ＨＴＭＬ帮助系统及它与旧帮助系统的不同点。最后介绍ＣＨＭ帮助文件的特点、发展和应用前景，以及ＣＨＭ文件的创建过程。     

红曲米中Monacolin K提取条件的优化

功能性红曲米含有Monacolin K,常作为一味能调节人体血脂水平的传统中药,实验采用响应面法对红曲米中Monacilin K的提取条件进行优化。结果表明:当提取条件为乙醇浓度67%,提取时间65min,温度43℃,料液比116,功率150 W时,提取的Monacolin K预测值为21.02mg·g-1,实际检测值为21.00mg·g-1,比商家提供的含量提高了40%。 更多还原     

ZnO薄膜的自组织设计及形貌控制

采用单源化学气相沉积(SSCVD)法,在Si(100)基片上通过改变前驱反应体与基片的入射角度,获得了可控柱状取向的ZnO薄膜.研究发现,入射角度的改变可使沉积薄膜中的柱状结构的生成方向倾斜.但X射线衍射(XRD)分析表明:ZnO薄膜的c轴(002)取向与入射角无关,且不沿ZnO柱状结构的生长方向取向.由于ZnO的(002)面为其表面自由能最低且原子密度高的晶面,ZnO薄膜的生长更易于在垂直于基片表面的方向c轴取向生长.     

A hybrid strategy to control uncertain nonlinear chaotic system

In this paper, a new method, based on firefly algorithm(FA) and extreme learning machine(ELM), is proposed to control chaos in nonlinear system. ELM is an efficient predicted and classified tool, and can match and fit nonlinear systems efficiently. Hence, mathematical model of uncertain nonlinear system is obtained indirectly. For higher fitting accuracy, a novel swarm intelligence algorithm FA is drawn in our proposed way. The main advantage is that our proposed method can remove the limitation that mathematical model must be known clearly and can be applied to unknown nonlinear chaotic system.