丁苯酞-哒嗪酮衍生物的设计、合成及其抗凝活性研究

为了提高丁苯酞的抗血小板凝集活性,以6-氨基丁苯酞为起始原料,经重氮化/还原、环化、水解、脱氯、醚化和磺酰化反应合成了20个新型的丁苯酞-哒嗪酮衍生物,其结构经1H-NMR、13C-NMR和HRMS确证。体外抗血小板凝集活性测试结果表明:化合物6a、6b和6k对二磷酸腺苷(ADP)诱导的血小板凝集的抑制活性(IC50 = 44.9-180.0 μmol/L)优于先导化合物丁苯酞(IC50 = 1252 μmol/L)和阳性对照阿司匹林(IC50 = 1140 μmol/L);同时化合物 6b(IC50 = 63.6 μmol/L)和6k(IC50 = 191.9 μmol/L)对花生四烯酸(AA)诱导的血小板凝集也表现出显著的抑制活性。本研究为丁苯酞-哒嗪酮骨架在治疗缺血性脑卒中方面的研究提供了理论参考。     

二硫二磺酸掺杂聚苯胺电化学性能的研究

用聚有机二硫化物与聚苯质共混，是提高聚苯胺的电化学性能的有效方法之一．以二硫二磺酸为掺杂剂掺杂的聚苯胺,可明显地改善聚苯胺的电化学活性，使聚苯胶与掺杂剂中的－S－S－在相同的区域内共同参与氧化还原反应，提高了聚苯胺的电容量和充放电循环性．     

泛系分析：数学.方法论.相对论.辩证思维

基于对广义系统、泛导、泛对称、泛箱原理、泛系相对性提出了新的分析模式与新的相对数学化的简化强化的定义，发展了泛系方法论与泛系相对论的框架与理法，具体内容涉及相对普适的数学化的泛系，200类对偶，对偶转化，泛对称转化，泛系辩证，八畴方法，泛系数学方法，广义量化，逼近转化原则，泛等价定理，供求分析，思维实验，广义灰色系统，等等     

ASYMPTOTIC ANALYSIS OF MODE Ⅱ STATIONARY GROWTHCRACK ON ELASTIC-ELASTIC POWER LAWCREEPING BIMATERIAL INTERFACE

A mechanical model was established for mode Ⅱ interfacial crack static growingalong an elastic-elastic power law creeping bimaterial interface. For two kinds of boundaryconditions on crack faces, traction free and frictional contact, asymptotic solutions of thestress and strain near tip-crack were given. Results derived indicate that the stress andstrain have the same singularity, there is not the oscillatory singularity in the field; thecreep power-hardening index n and the ratio of Young‘s module notably influence the crack-tip field in region of elastic power law creeping material and n only influences distribution ofstresses and strains in region of elastic material. When n is bigger, the creepingdeformation is dominant and stress fields become steady, which does not change with n.Poisson‘s ratio does not affect the distributing of the crack-tip field.     

长寿命、高安全性的Li4Ti5O12／LiMn2O4锂离子电池

自Sony公司推出锂离子二次电池以来，以AC／LiCoO2体系为主的商品锂离子电池由于具有高容量、高电压、环境友好等优势，已在便携式电子设备领域得到了广泛应用。但由于C／LiCoO2体系的锂离子电池存在成本、安全和寿命等方面的问题，限制了其在动力和储能领域的应用。选择合适的锂离子电池材料，开发新的电池体系是解决问题的关键。     

Enantioseparation of Novel Chiral Tetrahedral Clusters on an Amylosoe Tris-（3,5-dimethylphenylcarbamate） Chiral Stationary Phase by Normal Phase HPLC

Amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) coated on a kind of small particle silica gel was prepared. On this ADMPC chiral stationary phase (CSP), the direct enantiomeric separation of six novel chiral transition metal tetrahedral clusters has firstly been achieved using n-hexane as the mobile phase containing various alcohols as modifiers. The effect of mobile phase modifiers and the structural variation of the solutes on their retention factors (k‘) and resolutions (Rs) were investigated. The result suggests that not only the structure and concentration of alcohol in mobile phase, but also the structural differences in racemates can have a pronounced effect on enantiomeric separation. ADMPC-CSP is a suitable CSP for the optical resolution of chiral tetrahedral cluster by HPLC.     

双泵浦光子晶体光纤参量放大研究

利用光子晶体光纤在不同零色散波长附近具有不同色散的特性,研究了在零色散波长为780 nm和1550 nm附近的双泵浦光子晶体光纤参量放大过程.在780 nm附近,讨论了零色散波长变化对双泵浦光子晶体光纤参量放大的影响.数值模拟结果表明:当零色散波长发生微小的变化时,信号增益谱带宽会发生很大的变化.当两泵浦光之间的波长差值减小时,零色散波长的变化对参量放大的影响在很大程度上可以得到抑制,但是增益带宽会有一定的减小.依据这一原理,在1550 nm附近设计光子晶体光纤中的色散平坦光纤参量放大,在5 m长的光子晶体光纤中,当峰值功率为10 W时,得到了增益为65 dB,带宽达到420 nm且极为平坦的增益谱.     

S1P3受体拮抗剂TY-52156的合成工艺优化

以3,3-二甲基-2-丁酮、乙酸乙酯和对氯苯胺为起始原料,经Claisen缩合、氯代、重氮化、亲核取代等五步反应生成目标产物TY-52156,总收率为42.4%。目标化合物结构经1H-NMR、13 C-NMR和HRMS确证。通过优化Claisen缩合(t-BuOK/MTBE)及亲核取代(AcONa/EtOH)两步的反应条件,使其总收率比原有路线提高了1.36倍,更适合较大规模制备TY-52156。     

钠离子电池正极材料NaNi_(1/3)Co_(1/3)Mn_(1/3)O_2高压衰减机理（英文）

首次通过简单的固相反应合成了NaNi_(1/3)Co_(1/3)Mn_(1/3)O_2材料,并对其合适的电化学工作条件进行了探索。在此基础上对其在高充电电压下的衰减机理进行了研究。通过非原位XRD和电化学阻抗谱等电化学手段综合分析高充电电压下的衰减机理,发现随着充电电压升高至4 V,界面层的不断增厚与材料结构的不可逆变化同时导致了电化学性能的衰减。     

CeO2-ZrO2复合氧化物的制备及协同抛光性能

Sub-micrometer ultra fine CeO₂-ZrO₂ mixed oxides have been prepared by milling solid cerium carbonate and zirconium oxy-chloride with ammonia and followed by filtering, drying and calcining procedures. The effects of Ce/Zr molar ratio, milling time and calcining temperature on the phase composition, particle size and morphology, surface charge, as well as the polishing property were investigated. The results show that the mixed oxide calcined at 1 000 ℃ is composed of cubic ceria doped with zirconium and tetragonal zirconia doped with cerium, and the phase composition varies with calcination temperature and the Ce/Zr molar ratio. The monoclinic zirconia is observed when decreasing calcination temperature and shortening milling time, demonstrating that milling and calcining can force the phase transformation from monoclinic zirconia to cerium stabilized tetragonal zirconia and zirconium doped cubic ceria solid solutions. The removal rate for the optical glass polishing varies with Ce/Zr molar ratio. A synergetic polishing effect is found when Ce/Zr molar ratio below 4, and the optimal Ce/Zr molar ratio is 1∶1. At the same time, the cubic ceria content, density, particle size and surface charge all increase when calcination temperature increasing from 800 ℃ to 1 100 ℃. However, the particle morphology changes from disperse quasi-sphere to irregular aggregation and the maximal removal rate for optical glass polishing lies at 1 000 ℃.These facts show that the polishing property of the synthesized ceria-zirconia mixed oxide is affected by the particle physical characteristics comprehensively.