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姚静 《高等学校计算数学学报》2002,24(2):135-144
In this paper,we consider the problem of minimizing a particular class of quasi-differentiable functions:min{f(x)=max min fij(x)}.An algorithm for this problem is giver.At each iteration by solving quadratic programming subproblems to generate search directions,its convergence is proved in the sense of inf-stationary points. 相似文献
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非线性捕食-被捕食反应扩散系统的奇摄动 总被引:4,自引:0,他引:4
在适当的条件下,利用微分不等式理论,讨论了一个初始边值问题解的存在性和渐近性态.微分不等式理论的实质是构造两个辅助函数作为系统的上、下解.本文是利用微分不等式方法来研究一类生物数学中的非线性奇摄动捕食一被捕食反应扩散系统.然后使上、下解分别满足相应的不等式.最后证明所研究的系统存在解并处在上、下解之间,从而证明了系统解的存在性,并同时得到解的估计。 相似文献
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Biophysical model for high-throughput tumor and epithelial cell co-culture in complex biochemical microenvironments 下载免费PDF全文
The in vivo tumor microenvironment is a complex niche that includes heterogeneous physical structures,unique biochemical gradients and multiple cell interactions.Its high-fidelity in vitro reconstruction is of fundamental importance to improve current understandings of cell behavior,efficacy predictions and drug safety.In this study,we have developed a high-throughput biochip with hundreds of composite extracellular matrix(ECM)microchambers to co-culture invasive breast cancer cells(MDA-MB-231-RFP)and normal breast epithelial cells(MCF-10 A-GFP).The composite ECM is composed of type I collagen and Matrigel which provides a heterogeneous microenvironment that is similar to that of in vivo cell growth.Additionally,the growth factors and drug gradients that involve human epidermal growth factor(EGF),discoidin domain receptor 1(DDR1)inhibitor 7 rh and matrix metalloproteinase inhibitor batimastat allow for the mimicking of the complex in vivo biochemical microenvironment to investigate their effect on the spatial-temporal dynamics of cell growth.Our results demonstrate that the MDA-MB-231-RFP cells and MCF-10 A-GFP cells exhibit different spatial proliferation behaviors under the combination of growth factors and drugs.Basing on the experimental data,we have also developed a cellular automata(CA)model that incorporated drug diffusion to describe the experimental phenomenon,as well as employed Shannon entropy(SE)to explore the effect of the drug diffusion coefficient on the spatial-temporal dynamics of cell growth.The results indicate that the uniform cell growth is related to the drug diffusion coefficient,which reveals that the pore size of the ECM plays a key role in the formation of complex biochemical gradients.Therefore,our integrated,biomimetic and high-throughput co-culture platforms,as well as the computational model can be used as an effective tool for investigating cancer pathogenesis and drug development. 相似文献
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The ENSO is an interannual phenomenon involved in the tropical Pacific ocean-atmosphere interaction. In this article, we create an asymptotic solving method for the nonlinear system of the ENSO model. The asymptotic solution is obtained. And then we can furnish weather forecasts theoretically and other behaviors and rules for the atmosphere-ocean oscillator of the ENSO. 相似文献