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Synthesis of a nitro analogue of plakoric acid is presented. The peroxy bond was incorporated into the substrate structure through a boron trifluoride etherate catalyzed methoxy-hydroperoxy group partial exchange reaction in diethyl ether with urea-hydrogen peroxide complex (UHP, a commercially available solid reagent) as the source of the hydrogen peroxide. Under the given conditions, only one of the two methoxyl groups underwent the MeO—— OOH exchange and the resulting hydroperoxy hemiketal proceeded directly to the end product through an intramolecular Michael addition of the hydroperoxyl group to the nitro group activated carbon-carbon double bond. 相似文献
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IntroductionIn 1988,fromanaqueousextractionofChinesecin namon ,whichhaslongbeenusedinthetraditionalChi nesemedicineasadiaphoretic ,antipyretic ,oranalgesicagent,Fukayaandco workersisolatedcassioside (1)andfoundthatthiscompoundpossessedremarkableantiul cerogeni… 相似文献
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有机过氧化物目前已发展成非常重要的一类抗疟药物. 形成/引入过氧键是合成有机过氧化物的关键步骤和难点所在. 对合成有机过氧化物时常见的建立或引入过氧键的方法、各方法的适用范围及优劣所在作了简要的综述. 相似文献
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Reaction of a 1,2, 4, 5-tetraoxane with cysteinate-iron in the presence of excess methyl cysteinate led to formation of sulfuralkylated methyl cysteinate in 33 % yield, illustrating a possible mechanism for tetraoxanes‘ antimalarial action. 相似文献
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本文简要介绍了2005年至今有机合成领域的进展,第一部份有机合成方法学的一些新进展中突出介绍了金属参与的有机合成反应、自由基介导的合成反应、"一个反应瓶"内的多步反应以及不对称反应四个方面;第二部份复杂天然产物全合成则以10个分子的为例介绍这方面的进展。 相似文献
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Synthesis of a 1,2,7,8-Tetraoxa-spiro[5.5]undecane 总被引:1,自引:0,他引:1
Synthesis of a new spiro organic peroxide is described. The peroxy bonds were incorporated into the substrate framework via an acid-catalyzed ketal exchange reaction using hydrogen peroxide as the source of peroxy linkage. The hydroperoxyl groups were then bonded at the OH ends via Hg(II)-induced electrophilic additions to the C-C double bonds, giving a novel sprio structure with one peroxy bond in each of the two six-membered rings. The ester functionalities in the side chains also make it possible to conduct further structural modifications. 相似文献
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Several simple analogues of peroxyplakoric acid were synthesized by using Kobayashi's method to construct the key 1,2-dioxane core and tested in vitro for antimalarial activity. The scope and limitation of the method was also briefly examined. 相似文献