Determination of mitomycin C in plasma, serum and urine by high-performance liquid chromatography with ultra-violet and electrochemical detection

The performance of a number of normal phase and reversed-phase systems, with ultraviolet detection at 360 nm, has been investigated with respect to their applicability to pharmacokinetic studies of mitomycin C (MMC). The reversed-phase system developed was also combined with a polarographic detector in order to compare the sensitivity and selectivity of ultraviolet and electrochemical detection. A simple isolation procedure, based on the adsorption of MMC on a non-ionogenic resin, has been developed. The developed assay is applied to a pharmacokinetic study from which some examples are given.     

Preparation of α- and γ-(α-furyl)pyridines

Mixtures of isomeric alkyl-substituted (in the pyridine ring) - and -(-furyl)-pyridines were obtained in up to 40% yields by condensation of furfural and ammonia with several aliphatic ketones and aldehydes (at 370–380 °C with a cadmium calcium phosphate catalyst). The dependence of the yields and structures of the corresponding isomers on the structure of the starting carbonyl compound was examined. Data from the PMR and mass spectra were used to prove the structures of the pyridine bases obtained.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 383–387, March, 1981.     

Wechselwirkung zwischen entgegengesetzt geladenen Polypeptiden

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