Cytotoxic effect,enzyme inhibition,and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif

Molecular Diversity - The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and hCAIs) remain key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity...     

Some Tauberian conditions for Cesàro summability method

Let u = (u _n ) be a sequence of real numbers whose generator sequence is Cesàro summable to a finite number. We prove that (u _n ) is slowly oscillating if the sequence of Cesàro means of (ω _n ^(m−1)(u)) is increasing and the following two conditions are hold:

The inverse of nonsymmetric two-level Toeplitz operator matrices

The Gohberg–Semencul formula allows one to express the entries of the inverse of a Toeplitz matrix using only a few entries (the first row and the first column) of the inverse matrix, under some nonsingularity condition. In this paper we will provide a two variable generalization of the Gohberg–Semencul formula in the case of a nonsymmetric two-level Toeplitz matrix with a symbol of the form $f(z_1\text{,}{z}_2)=\frac{1}{\overline{P(z_1\text{,}{z}_2)}Q(z_1\text{,}{z}_2)}$ where $P(z_1\text{,}{z}_2)$ and $Q(z_1\text{,}{z}_2)$ are stable polynomials of two variables. We also consider the case of operator valued two-level Toeplitz matrices. In addition, we propose an equation solver involving two-level Toeplitz matrices. Numerical results are included.     

Heat capacities and thermodynamic functions of CdNb2O6 and CdTa2O6

Journal of Thermal Analysis and Calorimetry - The molar heat capacity parameters of CdNb2O6 and CdTa2O6 oxides, which attracted attention for their promising catalytic and optical properties, were...     

Direct C—H Bond Activation of Benzoxazole and Benzothiazole with Aryl Bromides Catalyzed by Palladium(II)‐N‐heterocyclic Carbene Complexes

Herein, we report that a series of novel palladium(II)‐NHC complexes (NHC=N‐heterocyclic carbene) were synthesized. The structures of all novel complexes were characterized by ¹H NMR, ¹³C NMR, FT‐IR spectroscopy and elemental analysis techniques. These palladium(II)‐NHC complexes were tested as efficient catalysts in the direct C—H bond activation of benzoxazole and benzothiazole with aryl bromides in the presence of 1 mol% catalyst loading at 150 °C for 4 h. Under the given conditions, various aryl bromides were successfully applied as the arylating reagents to achieve the 2‐arylbenzoxazoles and 2‐arylbenzothiazoles in acceptable to high yields.     

Evaluation of infection imaging potential of <Superscript>131</Superscript>I-labeled imidazolium salt

Effective antimicrobial compounds are necessary due to increased resistance of antibiotics against microorganisms causing infectious diseases. In this study, imidazolium-TFSI salt [ITFSI: octyl-bis(3-methylimidazolium)-di(bis(trifluoromethane)sulfonimide)] was labeled with ¹³¹I with high efficiency. In vitro uptake experiments of ¹³¹I-ITFSI showed high uptake in gram-positive Staphylococcus aureus bacteria. ¹³¹I-ITFSI was also evaluated for comparison between bacterial infection and sterile inflammation by in vivo studies. The biodistribution results revealed that ¹³¹I-ITFSI might be used as a nuclear imaging agent for detection of bacterial infection.     

Trace Elemental Analysis of Allium Species by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) with Multivariate Chemometrics

Aerial parts and roots of the 12 Allium species collected from five localities of Turkey were studied for trace elements (Ag, As, Cd, Co, Cr, Cu, Ni, Pb, Se, Tl, V, and Zn) using inductively coupled plasma mass spectrometry (ICP-MS). A tomato leaves certified reference material was used to characterize the accuracy and precision of the analysis. Each Allium species contained Se (315–2740?µg/kg), Tl (2.75–71?µg/kg), V (77–6790?µg/kg), and Zn (3.73–26.6?mg/kg) which can meet the necessary daily intake of these minerals. In addition, chemometric analyses were performed using correlation analysis, principal component analysis, and hierarchical cluster analysis to determine the association of 12 trace elements in the Allium species. Using chemometrics, the distribution of elements between aerial parts and roots, and geographic collection localities of Allium species were also examined. This study is important the consumers because of the wide consumption of Allium species. This report is the first detailed characterization of the metal content of Allium species.     

Characterization of the Chemical Profile of Euphorbia Species from Turkey by Gas Chromatography–Mass Spectrometry (GC-MS), Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS), and Liquid Chromatography–Ion Trap–Time-of-Flight–Mass Spectrometry (LC-IT-TOF-MS) and Chemometric Analysis†

The Euphorbiaceae family comprises of about 300 genera and 5000 species primarily distributed in America and tropical Africa. The Euphorbia genus is represented by 105 species and locally named as “Sütle?en” and “Xa?îl” in Turkey. The present study aimed to determine the chemical constituents of E. aleppica, E. eriophora, E. macroclada, E. grisophylla, E. seguieriana subsp. seguieriana, E. craspedia, E. denticulata, E. falcata, and E. fistulosa, and classify them by utilizing the chemometric techniques of principal component analysis (PCA) and hierarchical cluster analysis (HCA). Linoleic acid, 17-tetratriacontane, palmitic acid, and hexatriacontane were the major fatty acids from the gas chromatography–mass spectrometry (GC/MS) analyses. Characterization of 268 constituents of the studied species was achieved by liquid chromatography–ion trap–time-of-flight–mass spectrometry (LC-IT-TOF-MS). Furthermore, a new liquid chromatography–tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous quantitative determination of 11 compounds (quinic acid, protocatechuic acid, rutin, hesperidin, eugenol, p-coumaric acid, piceatannol, scopoletin, dl-kavain, chrysophanic acid, and resiniferatoxin) in these species. The developed method was validated for the linearity, limit of detection, limit of quantification, repeatability, and recovery.     

Investigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive 131I in the cancer cell lines

The aim of this study is to determine the incorporations of PHT radiolabeled with ¹³¹I (¹³¹I-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of ¹³¹I-PHT was obtained about 95 %. Subsequently, cell culture studies were carried out and radio-labeling yields of ¹³¹I, ¹³¹I-PHT on U-87 MG, Daoy and A549 cancerous cells were investigated. Cell culture studies demonstrated that the incorporation values of ¹³¹I-PHT on the three cell lines decreased with increasing radioactivity. Consequently, ¹³¹I-PHT may be a good radiopharmaceutical for targeting radionuclide therapy of Central Nervous System Tumors.     

Synthesis and Thermal Properties of a Novel Schiff Base Oligomer with a Double Azomethine Group and its Co(II) and Mn(II) Complexes

Schiff base oligomer of N,N′‐bis (2,4‐dihydroxybenzylidene) 1,2‐phenylenediamine (DHBPDA), with a double azomethine group, was synthesized from the oxidative polycondensation (OP) reaction with NaOCl as an oxidant in an aqueous alkaline medium at 90°C. About 75% DHBPDA was converted to O‐DHBPDA. The structures of the products were studied by UV‐Vis, FT‐IR, ¹H‐NMR, ¹³C‐NMR and elemental analysis. According to Gel Permeation Chromatography (GPC) analysis of O‐DHBPDA, the number average molecular weight (M_n), weight average molecular weight (M_w) and PDI values were found to be 4328 g mol^?1, 6228 g mol^?1 and 1.43, respectively. TG/DTA analyses were shown to be stable of O‐DHBPDA against thermo‐oxidative decomposition. During the polycondensation reaction, a part of the azomethine (‐CH?N‐) groups oxidized to aldehyde (CHO) group (10–12%). Oligomer‐metal complexes of oligo‐N,N′‐bis (2,4‐dihydroxybenzylidene) 1,2‐phenylenediamine (O‐DHBPDA) with Co(II) and Mn(II) were synthesized and characterized by FT‐IR, UV‐Vis, TG‐DTA and Atomic Absorption Spectroscopy (AAS). The residue of DHBPDA, O‐DHBPDA, O‐DHBPDA‐Co and O‐DHBPDA‐Mn were found to be 0%, 3.65%, 11.67%, and 9.20%, respectively at 1000°C.