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排序方式: 共有3815条查询结果,搜索用时 46 毫秒
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Andrey Vyacheslavovich Vasilyev Valeriya Sergeevna Kuznetsova Tatyana Borisovna Bukharova Timofei Evgenevich Grigoriev Yuriy Dmitrievich Zagoskin Irina Alekseevna Nedorubova Igor Ivanovich Babichenko Sergey Nicolaevich Chvalun Dmitry Vadimovich Goldstein Anatoliy Alekseevich Kulakov 《Molecules (Basel, Switzerland)》2021,26(2)
Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties. To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56. A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo. The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times. Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain. Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation. When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material’s thickness. Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect. Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2 were also shown in subcutaneous implantation. 相似文献
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Alexey Yurasov Alexander Granovsky Sergey Tarapov Jean-Pierre Clerc 《Journal of magnetism and magnetic materials》2006
The transmission of millimeter-range electromagnetic waves (30–50 GHz) through a magnetic nanocomposite thin film exhibiting tunnel magnetoresistance (TMR) is calculated. The relative change of transmission coefficient in an applied magnetic field due to the magnetorefractive effect is approximately linear with TMR and strongly depends on nanocomposite resistivity and film thickness. The obtained results are in a good agreement with experiment. 相似文献
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We consider the Brown–Ravenhall model of a relativistic atom with N electrons and a nucleus of charge Z and prove the existence of an infinite number of discrete eigenvalues for N⩽ Z. As an intermediate result we prove a HVZ-type theorem for these systems.
Communicated by Rafael D. Benguria
Submitted: 9/11/2005 Accepted: 15/12/2005 相似文献
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Sergey Chervon 《General Relativity and Gravitation》2004,36(7):1547-1553
A new strategy of exact solutions construction in inflationary cosmology within the self-interacting scalar field theory is proposed. It is shown that inflationary models have no restrictions dictated by the slow-roll approximation on the self-interacting potential. The suggested approach makes it possible to compute precisely the e-folds numbers in inflationary scenarios. The scalar field with a logarithmic evolution in time is analyzed in details. Other possible types of scalar field evolution are discussed. 相似文献