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The genesis and elimination of early afterdepolarizations (EADs) have been investigated in guinea pig cardiac ventricular fibers after a short period of cooling (5h, 2—4℃). After rewarming them to 37℃, EADs could be induced by K~+-free superfusion at an appropriate driving stimulation (0.2 Hz) in all preparations. A high level plateau, which linearly increases its duration with time, appears ahead of EADs. The critical point of the plateau occurred steadily at the level of -47±4 mV. Two types of triggered activity, all of which are the rhythmic activities in low level of membrane potential (-50 to -60 mV), appear on the platcau. There is no significant change after overdriving. Agonists of the Na-K pump (K~+ and Tl~+) could stop the rhythmic activity immediately and turn the low level of membrane potential to high one. The results showed that high level plateau is the basis of genesis of EADs, and the activation of Na-K pump plays an important part in stopping triggered rhythms arising from EADs. 相似文献
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本文在短期低温处理后(5h,2—4℃)的豚鼠心室肌标本上,探讨了早发后去极化(EAD)的发生。在适当地驱动刺激(0.2Hz)下,复温后的心室肌标本经无钾溶液灌流后均可诱发EAD产生。EAD出现之前,动作电位于复极3期首先形成一新的“低位平台”。此平台可随时间呈线性增长,其拐点恒定在动作电位复极至—47±4mV的膜电位水平。由EAD触发形成的非驱动反应呈两种电位形式,但均属低膜电位水平(—50——60 mV)的节律性活动。超速驱动无明显影响,钠泵激动剂(K~+及Tl~+)可有效而迅速地终止触发性节律活动,并使低膜电位转变为高膜电位。结果表明:“低位平台”是EAD形成的基础;钠泵的激动在消除EAD触发的节律活动中起重要作用。 相似文献
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讨论了鉴定未知光纤是否符合非色散位移单模光纤特征的检测过程。光纤种类繁多。在进行鉴定时应结合非色散位移单模光纤的特征进行系统性的检测。检测过程中可首先判断未知光纤是否属于通信用单模光纤,再通过非色散位移单模光纤与其他通信用单模光纤的技术差异进一步鉴定。鉴定过程可能涉及到光纤几何参数、色散系数、宏弯损耗等多项指标的检测,文中给出了推荐的检测方法。 相似文献
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The traditional critical membrane potential (CMP), -55—-60mV, which corresponds to effective refractory period (ERP), was anew investigated in guinea pig ventricular muscle fibres. The electrical and contractile responses to the stimulus during repolarization of action potential (AP), particularly from+10 to -60 mV, were observed. One third of 35 tested cells displayed testing action potential (TAP) and local response at≥-54 mV when they were stimulated by testing pulses in 37℃ normal Tyrode's solution. Potential level of TAP which occurred earliest was at -30 mV and that of local response which appeared earliest was at 0 mV during repolarization among 95 systematic tests. Most of the TAPs belonged to the slow response potential type. The ratio of TAP evoked at ≥-54 mV initial membrane potential (IMP) was as high as 86% when the experiment was carried out in 37℃ 1.5 mmol KC1/L Tyrode's solution. In view of distribution of IMPs of TAPs, the CMP of ERP in guinea pig ventricular muscle fibres was more 相似文献
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图像隐写是一种将信息隐藏于数字图像中的技术,而隐写检测算法试图分辨出藏有信息的图像。文中分析了现有隐写检测算法的优势,结合HUGO隐写算法的特点,提出了一种改进的基于局部纹理特征的隐写检测算法。该算法由LOCP和LPQ这两种局部纹理特征组成。由于提取到的特征维度很大,因此选用了Ensemble分类器进行训练与检测。在HUGOBOSS 1.0图像库上的实验显示,提出的隐写检测算法比原有算法更准确地区分出原始图像和隐写图像,并获得了83.65%的检测准确率。 相似文献
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Early afterdepolarization (EAD) in mouse atrial fibers was investigated under the treatment with aconitine, 3. 0 mmol/L K+ ,quinidine, ryanodine or Bay k 8644. All of these EADs possessed the following common characteristics j all the parameters of EAD showed cycle length-dependence; take-off potential of the first triggered burst played an important role in the generation of the other parameters ; hyper-polarization of the triggered brust enhanced the end of EAD; and the second plateau response might be used as an indicator of the capability of EAD generation of myocardiac cell. All those EADs were inhibited or abolished by nifedipine, tetrodotoxin or lidocaine. Potassium channel activators, lemakalim, thalium ion, acetyl-choline or high potassium could also inhibit or abolish the EADs. It is suggested that the EADs induced by different agents may base on a common mechanism ; all currents contributing to the plateau phase of the action potential play an important role in the generation of EAD. 相似文献