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1.
Issa Yavari Zinatossadat Hossaini Maryam Sabbaghan 《Monatshefte für Chemie / Chemical Monthly》2007,8(4):107-110
Protonation of the highly reactive 1:1 intermediates produced in the reaction between alkyl(aryl) isocyanides and dibenzoylacetylene
by isatin, leads to vinylnitrilium cations, which undergo carbon-centered Michael-type addition with the conjugate base of the NH-acid to produce highly functionalized 1-(3-furyl)-1H-indole-2,3-diones. A dynamic NMR effect is observed in the 1H NMR spectra of these compounds as a result of restricted rotation around the single bond linking the indole moiety and the
furan system. The free-energy of activation (ΔG
#) for this process is 69–71 ± 2 kJ mol−1. 相似文献
2.
Molecular Diversity - In current research, benzazepine derivative is synthesized via a new process of four-component reaction of isatin or its derivatives, α-haloketones, activated acetylenic... 相似文献
3.
Seyyedeh Fatemeh Mousavi Zinatossadat Hossaini Faramarz Rostami-Charati Navabeh Nami 《Journal of heterocyclic chemistry》2020,57(11):3868-3881
In this research, synthesis of pyrrolo isoquinoline derivatives in excellent yields was performed using the multicomponent reaction of isoquinoline, alkyl bromides, 2-hydroxyacetophenone, or its derivatives, dimethyl carbonate as a green reagent and KF/clinoptinolite nanoparticles as a catalyst in the aqueous media at 80°C. The Punica granatum peel water extract was used as the green media for the synthesis of PG-KF/clinoptilolite nanoparticles in high yield. The PG-KF/clinoptilolite nanoparticles show a significant basic catalytic role in these reactions in preparing the product in high yield and used for several times. In addition, for studying the antioxidant ability of some of the synthesized compounds, diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction tests are employed. The short time of the reaction, high yields of the product, easy separation of the catalyst and products are some of the advantages of this procedure. 相似文献
4.
Isoquinoline reacts with ethyl bromopyruvate in the presence of dialkyl acetylenedicarboxylates or diaryloylacetylenes to produce dialkyl 1-(2-ethoxy-2-oxoacetyl)pyrrolo[2,1-a]isoquinoline-2,3-dicarboxylates or ethyl 2-[2,3-diaryloylpyrrolo[2,1-a]isoquinoline-1-yl]-2-oxoacetates in good yields. 相似文献
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6.
Summary The reaction between alkyl isocyanides and isopropylidene Meldrum’s acid in the presence of 1,2-ethanediol leads to N
1-(alkyl)-2-(5,7-dioxo-1,4-dioxepane-6-yl)-2-methylpropanamides. 1,3-Propanediol or 1,4-butanediol produce hydroxyalkyl 1-(tert-butyl)-4,4-dimethyl-2,5-dioxo-3-pyrrolidinecarboxylates. When the reaction was performed in the presence of catechol, bis(2-hydroxyphenyl)
2-[2-(tert-butylamino)-1,1-dimethyl-2-oxoethyl]malonate was obtained. 2-Aminophenols react with alkyl isocyanides in the presence of
isopropylidene Meldrum’s acid to produce 1-alkyl-N
3-(2-hydroxyaryl)-4,4-dimethyl-2,5-dioxo-3-pyrrolidinecarboxamides in good yields. 相似文献
7.
Faramarz Rostami Charati Zinatossadat Hossaini Mohammad R. Hosseini‐Tabatabaei 《Journal of heterocyclic chemistry》2012,49(1):154-160
A straightforward and efficient method for the synthesis of 1,2‐dihydroisoquinolines via a one‐pot, three‐component reaction of isoquinoline, activated acetylenes, and NH‐acids in water at 70°C without using any catalyst is reported. The method offers several advantages including high yields of products and an easy workup procedure. J. Heterocyclic Chem., (2012). 相似文献
8.
Issa Yavari Maryam Sabbaghan Zinatossadat Hossaini Majid Ghazanfarpour‐Darjani 《Helvetica chimica acta》2008,91(6):1144-1147
Triphenyl phosphite reacts smoothly with dialkyl acetylenedicarboxylates and hexachloroacetone to produce alkyl 2‐(dichloromethylene)‐2,5‐dihydro‐5‐oxo‐4‐(trichloromethyl)furan‐3‐carboxylates in good yields. 相似文献
9.
Hossaini Z Rostami-Charati F Firoziyan S Sabbaghan M Khalilzadeh MA 《Combinatorial chemistry & high throughput screening》2012,15(6):503-508
An efficient synthesis of dialkyl pyrrolo[2,1-a]isoquinoline-2,3-dicarboxylates, pyrrolo[1,2-a]quinoline-1,2- dicarboxylates and indolizines is described via one-pot reactions of isoquinoline, quinoline or pyridine and phenacyl bromids with dialkyl acetylenedicarboxylates or diaryloylacetylene under solvent-free conditions at 50°C. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods. 相似文献
10.
Mohammad A. Khalilzadeh Issa Yavari Zinatossadat Hossaini Hasan Sadeghifar 《Monatshefte für Chemie / Chemical Monthly》2009,140(4):467-471
Abstract A novel method for oxazine ring formation is established using the reaction of ammonium thiocyanate and acid chlorides with
napthols in the presence of N-methylimidazole to afford [1,3]oxazine-4-thione derivatives in excellent yields.
Graphical abstract
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