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1.
Harshad S. Kapare Ranjitsinh Pawar Vrushali Neve Vrushali Bhalchim Prabhanjan S. Giram 《先进技术聚合物》2024,35(3):e6348
In recent years, advanced polymeric dendrimers have emerged as a promising avenue for AD management. Dendrimers are highly branched, three-dimensional macromolecules with precise nanoarchitectures, making them ideal candidates for the delivery of therapeutic agents and diagnostic tools. Their unique properties, such as well-defined size, multifunctionality, and controlled surface chemistry, allow for the design of targeted and highly efficient drug delivery systems and diagnostic probes. This review aims to provide a comprehensive overview of the potential applications of advanced polymeric dendrimers in the management of Alzheimer's disease. We explored their role in drug delivery, diagnostics, and other therapeutic interventions for AD. Additionally, we will delve into the challenges and opportunities in utilizing dendrimers as a key player in the battle against this devastating disease. The review will begin by discussing the current state of Alzheimer's disease, including its pathological features, clinical manifestations, and existing treatment strategies. It will then transition to an in-depth examination of polymeric dendrimers, highlighting their structural characteristics, synthesis methods, and biocompatibility. Subsequently, the review will delve into the various ways in which dendrimers can be tailored for AD management, including drug encapsulation and delivery, enhanced blood–brain barrier penetration, and targeted diagnostic imaging. Furthermore, we explored the potential benefits of dendrimer-based therapies, such as improved drug efficacy, reduced side effects, and enhanced patient compliance. The review will also address the challenges associated with dendrimer-based approaches, including toxicity concerns, regulatory hurdles, and the need for rigorous clinical evaluation. 相似文献
2.
In this paper we report the combustion synthesis of trivalent rare-earth (RE3+ = Dy, Eu and Ce) activated Sr4Al2O7 phosphor. The prepared phosphors were characterized by the X-ray powder diffraction (XRD) and photoluminescence (PL) techniques. Photoluminescence emission peaks of Sr4Al2O7:Dy3+ phosphor at 474 nm and 578 nm in the blue and yellow region of the spectrum. The prepared Eu3+ doped phosphors were excited by 395 nm then we found that the characteristics emission of europium ions at 615 nm (5D0?7F2) and 592 nm (5D0?7F1). Photoluminescence (PL) peaks situated at wavelengths of 363 and 378 nm in the UV region under excitation at around 326 nm in the Sr4Al2O7:Ce3+ phosphor. 相似文献
3.
In this paper we have analyzed the Kaluza-Klein type Robertson Walker (RW) cosmological models by considering three different
forms of variable Λ:
,
and Λ∼ρ. It is found that, the connecting free parameters of the models with cosmic matter and vacuum energy density parameters are
equivalent, in the context of higher dimensional space time. The expression for the look back time, luminosity distance and
angular diameter distance are also derived. This work has thus generalized to higher dimensions the well-known results in
four dimensional space time. It is found that there may be significant difference in principle at least, from the analogous
situation in four dimensional space time. 相似文献
4.
Copper-doped Na21(SO4)7F6Cl phosphor was synthesized via the conventional wet chemical method. The synthesis was carried using CuCl2 and Cu (NO3)2·3H2O as dopants in two different steps successively. The formation and phase purity of the compound were revealed by the X-ray diffraction pattern. Functional groups of the prepared phosphor were observed in the FT–IR spectrum. The emission along with excitation spectra were followed to explore the luminescence attributes. Photoluminescence (PL) emission spectrum of the material synthesized using CuCl2 as the dopant was observed at 358?nm due to 3dl0?3d94s transitions when excited around 247?nm for various copper concentrations. Efficient blue emissions were obtained at peaks 423 and 469?nm for materials synthesized using Cu (NO3)2·3H2O as the dopant, when monitored at 357?nm excitation. The Commission Internationale de I’Eclairage chromaticity coordinates for different copper concentrations were calculated for the emission around 423?nm. TL glow curves of Na21(SO4)7F6Cl:Cu phosphor for different dopant concentrations, irradiated with 100?Gy gamma dose, were studied and hence the trap parameters, namely order of kinetics (b), activation energy (E) and frequency factor (s) associated with the most intensive glow peak of Na21(SO4)7F6Cl:Cu phosphor were determined by using Chen’s Peak shape method. The results indicate that Na21(SO4)7F6Cl:Cu+ is a potential novel blue-emitting lamp phosphor and may be quite suitable for use in dosimetry of ionizing radiations. 相似文献
5.
Omprakash P. Bande Vrushali H. Jadhav Vedavati G. Puranik Dilip D. Dhavale Marco Lombardo 《Tetrahedron letters》2009,50(49):6906-6908
Intramolecular N-alkylation of 2,3-O-isopropylidene-5-O-methanesulfonyl-6-O-t-butyldimethylsilyl-d-mannofuranose-oxime 7 afforded a five-membered cyclic nitrone 9, which on N–O bond reductive cleavage followed by deprotection of –OTBS and acetonide functionalities gave 1,4-dideoxy-1,4-imino-l-allitol (DIA) 3. Addition of allylmagnesium chloride to nitrone 9 afforded α-allylated product 10a in high diastereoselectivity providing an easy entry to N-hydroxy-C1-α-allyl-substituted pyrrolidine iminosugar 4a after removal of protecting group, while N–O bond reductive cleavage in 10a afforded C1-α-allyl-pyrrolidine iminosugar 4b. 相似文献
6.
Vrushali H. Jadhav Omprakash P. Bande Vedavati G. Puranik Dilip D. Dhavale 《Tetrahedron: Asymmetry》2010,21(2):163-170
The Sharpless asymmetric epoxidation of d-glucose-derived allyl alcohol 4 afforded α- and β-epoxides 5a and 5b in high stereoselectivity. The epoxide ring opening in 5a/5b was studied with different nucleophilic azido reagents, under various reaction conditions, and was found to be highly regioselective to give the preferential formation of 6-azido diol 6a/6b over 5-azido-diol 7a/7b. The 6-azido diol 6a/6b and 5-azido diol 7a/7b thus obtained were converted to the corresponding seven- and six-membered iminosugar, namely, azepane 1a/1b and 1-deoxy-nojirimycin 2a/2b. 相似文献
7.
A simple, rapid, and accurate method based on thin-layer chromatography (TLC) combined with image-analysis software has been developed for analysis of steroid drug intermediates formed during bioconversion of soysterols. The results obtained have been compared with those from LC. The method has been used to monitor the accumulation of widely used steroid drug intermediates androst-4-ene-3,17-dione (AD) and androsta-1,4-diene-3,17-dione (ADD), formed during the bioconversion of soysterols by Mycobacterium sp. NRRL B-3805 and Mycobacterium sp. NRRL B-3683. The percentage error between TLC and LC ranged between ?0.79 to +4.50 for AD and ?0.61 to +2.48 for ADD. Maximum conversion of soysterols to AD and ADD by Mycobacterium sp. NRRL B-3805 was 49.83 and 9.36 mol%, respectively, after incubation for 144 h, whereas conversion of soysterols by Mycobacterium sp. NRRL B-3683 after incubation 288 h was 41.90 mol% for AD and 37.79 mol% for ADD. 相似文献
8.
A study of the effect of introduction of 3,6-anhydroglucose residues in the cellulose structure on glycoside hydrolysis rate was performed. A cellotetrose with an 3,6-anhydroglucose as the third residue was synthesised. Acidic hydrolysis of this tetrasaccharide showed that hydrolysis of the 3,6-anhydro-β-D-glucoside linkage was 31.400 times faster than hydrolysis of cellobiose. A series of different 3,6-anhydrocelluloses with different degree of substitution were prepared by tosylation of cellulose with varying amounts of tosyl chloride in dimethylacetamide and subsequent treatment with sodium hydroxide. Anhydrocelluloses with degrees of substitution of 0.02, 0.07, 0.31 and 0.74 were obtained. The anhydrocelluloses were subjected to acidic hydrolysis in 2.0 M aqueous HCl and the rate of hydrolysis monitored by ion chromatography analysis of the amount of glucose and/or cellobiose formed. All 3,6-anhydrocelluloses hydrolyzed with a faster rate than cellulose, but the anhydrocellulose with a low degree of substitution (ds = 0.07) hydrolyzed fastest which was 90 times faster than cellulose. 相似文献
9.
10.
Sanjeev R. Patil Aniket P. Sarkate Kshipra S. Karnik Ashish Arsondkar Vrushali Patil Jaiprakash N. Sangshetti Anil S. Bobade Devanand B. Shinde 《Journal of heterocyclic chemistry》2019,56(3):859-866
A series of novel substituted 2‐(5‐(benzylthio)‐1,3,4‐oxadiazol‐2‐yl)pyrazine derivatives ( 6a – n ) were synthesized under microwave irradiation and conventional conditions with less reaction time with good to excellent yields. All the synthesized compounds were screened for antioxidant and anticancer activities. Out of the 14 prepared derivatives, compounds 6f and 6m were most potent and active with antioxidant and anticancer activities, respectively. Also, the developed technique was simple, easy, and less time consuming. 相似文献